Mutagenesis and computer modeling studies of a GPCR conserved residue W5.43(194) in ligand recognition and signal transduction for CB2 receptor.
about
Receptor binding peptides for target-selective delivery of nanoparticles encapsulated drugsDifference and Influence of Inactive and Active States of Cannabinoid Receptor Subtype CB2: From Conformation to Drug Discovery.Modeling, molecular dynamics simulation, and mutation validation for structure of cannabinoid receptor 2 based on known crystal structures of GPCRs.Trisubstituted Sulfonamides: a New Chemotype for Development of Potent and Selective CB2 Receptor Inverse Agonists.CB2 cannabinoid receptor agonist enantiomers HU-433 and HU-308: An inverse relationship between binding affinity and biological potencyMastering tricyclic ring systems for desirable functional cannabinoid activity.Lead discovery, chemistry optimization, and biological evaluation studies of novel biamide derivatives as CB2 receptor inverse agonists and osteoclast inhibitorsNovel triaryl sulfonamide derivatives as selective cannabinoid receptor 2 inverse agonists and osteoclast inhibitors: discovery, optimization, and biological evaluation.Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic Potential for Neuroinflammation.Targeting cannabinoid receptor-2 pathway by phenylacetylamide suppresses the proliferation of human myeloma cells through mitotic dysregulation and cytoskeleton disruption.Ligand biological activity predictions using fingerprint-based artificial neural networks (FANN-QSAR).Examining the critical roles of human CB2 receptor residues Valine 3.32 (113) and Leucine 5.41 (192) in ligand recognition and downstream signaling activitiesMolecular fingerprint-based artificial neural networks QSAR for ligand biological activity predictions.The importance of hydrogen bonding and aromatic stacking to the affinity and efficacy of cannabinoid receptor CB2 antagonist, 5-(4-chloro-3-methylphenyl)-1-[(4-methylphenyl)methyl]-N-[(1S,2S,4R)-1,3,3-trimethylbicyclo[2.2.1]hept-2-yl]-1H-pyrazole-3-Selective cannabinoid 2 receptor stimulation reduces tubular epithelial cell damage following renal ischemia-reperfusion injury.
P2860
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P2860
Mutagenesis and computer modeling studies of a GPCR conserved residue W5.43(194) in ligand recognition and signal transduction for CB2 receptor.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Mutagenesis and computer model ...... transduction for CB2 receptor.
@ast
Mutagenesis and computer model ...... transduction for CB2 receptor.
@en
type
label
Mutagenesis and computer model ...... transduction for CB2 receptor.
@ast
Mutagenesis and computer model ...... transduction for CB2 receptor.
@en
prefLabel
Mutagenesis and computer model ...... transduction for CB2 receptor.
@ast
Mutagenesis and computer model ...... transduction for CB2 receptor.
@en
P2093
P2860
P1476
Mutagenesis and computer model ...... transduction for CB2 receptor.
@en
P2093
Brielle Schreiter
Jurg Gertsch
Lirong Wang
Xiang-Qun Xie
Yuxun Zhang
Zhaojun Xie
P2860
P304
P356
10.1016/J.INTIMP.2011.04.013
P50
P577
2011-05-01T00:00:00Z