CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-beta: evidence for TGF-beta but not IL-10-dependent direct S mu-->S alpha and sequential S mu-->S gamma, S gamma-->S alpha DNA recombination
about
Endonuclease G plays a role in immunoglobulin class switch DNA recombination by introducing double-strand breaks in switch regionsRegulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationHoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutationInduction of IgA and sustained deficiency of cell proliferative response in chronic hepatitis CThe HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombinationB cell TLRs and induction of immunoglobulin class-switch DNA recombination.High resolution analysis of the chromatin landscape of the IgE switch region in human B cellsLactobacillus gasseri SBT2055 induces TGF-β expression in dendritic cells and activates TLR2 signal to produce IgA in the small intestine.Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutationInnate signaling networks in mucosal IgA class switchingThe biology of intestinal immunoglobulin A responsesThe regulation of IgA class switching.An intrinsic propensity of murine peritoneal B1b cells to switch to IgA in presence of TGF-β and retinoic acid.AID to overcome the limitations of genomic information by introducing somatic DNA alterations.Absence of immunoglobulin class switch in primary lymphomas of the central nervous system.Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair.The CD40/CD40L costimulatory pathway in inflammatory bowel diseaseDivide and conquer: the importance of cell division in regulating B-cell responses.Induction of Ig somatic hypermutation and class switching in a human monoclonal IgM+ IgD+ B cell line in vitro: definition of the requirements and modalities of hypermutation.EBV-encoded latent membrane protein 1 cooperates with BAFF/BLyS and APRIL to induce T cell-independent Ig heavy chain class switchingOngoing in vivo immunoglobulin class switch DNA recombination in chronic lymphocytic leukemia B cells.The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.Isotype-specific selection of high affinity memory B cells in nasal-associated lymphoid tissueNew Member of the V1V2-Directed CAP256-VRC26 Lineage That Shows Increased Breadth and Exceptional PotencyIncreased synthesis of anti-tuberculous glycolipid immunoglobulin G (IgG) and IgA with cavity formation in patients with pulmonary tuberculosis.Hepatitis C virus infection activates the immunologic (type II) isoform of nitric oxide synthase and thereby enhances DNA damage and mutations of cellular genes.Lineage tracing of human B cells reveals the in vivo landscape of human antibody class switching.B cell-derived transforming growth factor-β1 expression limits the induction phase of autoimmune neuroinflammation.The human intestinal IgA response; burning questions.Human IgA-inducing protein from dendritic cells induces IgA production by naive IgD+ B cells.Engagement of CD153 (CD30 ligand) by CD30+ T cells inhibits class switch DNA recombination and antibody production in human IgD+ IgM+ B cells.AID-dependent generation of resected double-strand DNA breaks and recruitment of Rad52/Rad51 in somatic hypermutation.CD30 is a CD40-inducible molecule that negatively regulates CD40-mediated immunoglobulin class switching in non-antigen-selected human B cells.AID- and Ung-dependent generation of staggered double-strand DNA breaks in immunoglobulin class switch DNA recombination: a post-cleavage role for AID.Ongoing immunoglobulin class switch DNA recombination in lupus B cells: analysis of switch regulatory regions.B lymphocytes confer immune tolerance via cell surface GARP-TGF-β complex.Reciprocal influence of B cells and tumor macro and microenvironments in the ApcMin/+ model of colorectal cancer.Autoreactive IgG and IgA B Cells Evolve through Distinct Subclass Switch Pathways in the Autoimmune Disease Pemphigus Vulgaris
P2860
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P2860
CD40 engagement triggers switching to IgA1 and IgA2 in human B cells through induction of endogenous TGF-beta: evidence for TGF-beta but not IL-10-dependent direct S mu-->S alpha and sequential S mu-->S gamma, S gamma-->S alpha DNA recombination
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
1998年论文
@zh
1998年论文
@zh-cn
name
CD40 engagement triggers switc ...... ma-->S alpha DNA recombination
@ast
CD40 engagement triggers switc ...... ma-->S alpha DNA recombination
@en
type
label
CD40 engagement triggers switc ...... ma-->S alpha DNA recombination
@ast
CD40 engagement triggers switc ...... ma-->S alpha DNA recombination
@en
prefLabel
CD40 engagement triggers switc ...... ma-->S alpha DNA recombination
@ast
CD40 engagement triggers switc ...... ma-->S alpha DNA recombination
@en
P2093
P2860
P1476
CD40 engagement triggers switc ...... ma-->S alpha DNA recombination
@en
P2093
P2860
P304
P407
P577
1998-11-01T00:00:00Z