The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.
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The translesion DNA polymerase theta plays a dominant role in immunoglobulin gene somatic hypermutationRegulation of aicda expression and AID activity: relevance to somatic hypermutation and class switch DNA recombinationHoxC4 binds to the promoter of the cytidine deaminase AID gene to induce AID expression, class-switch DNA recombination and somatic hypermutationExpression of human AID in yeast induces mutations in context similar to the context of somatic hypermutation at G-C pairs in immunoglobulin genesHepatitis C virus E2-CD81 interaction induces hypermutation of the immunoglobulin gene in B cells.Selective inhibition of class switching to IgG and IgE by recruitment of the HoxC4 and Oct-1 homeodomain proteins and Ku70/Ku86 to newly identified ATTT cis-elementsThe HoxC4 homeodomain protein mediates activation of the immunoglobulin heavy chain 3' hs1,2 enhancer in human B cells. Relevance to class switch DNA recombinationDNA polymerase theta contributes to the generation of C/G mutations during somatic hypermutation of Ig genes.The transcription factor TFII-I promotes DNA translesion synthesis and genomic stabilityMsh2 ATPase activity is essential for somatic hypermutation at a-T basepairs and for efficient class switch recombinationPolymerase mu is up-regulated during the T cell-dependent immune response and its deficiency alters developmental dynamics of spleen centroblastsDNA polymerase zeta: new insight into eukaryotic mutagenesis and mammalian embryonic developmentHumanized Immunoglobulin Mice: Models for HIV Vaccine Testing and Studying the Broadly Neutralizing Antibody Problem.Activation-induced deaminase, AID, is catalytically active as a monomer on single-stranded DNA.Different mutation signatures in DNA polymerase eta- and MSH6-deficient mice suggest separate roles in antibody diversificationCorrelation of somatic hypermutation specificity and A-T base pair substitution errors by DNA polymerase eta during copying of a mouse immunoglobulin kappa light chain transgene.Somatic immunoglobulin hypermutation.AID and somatic hypermutation.Induction of somatic hypermutation in immunoglobulin genes is dependent on DNA polymerase iota.Response of human REV3 gene to gastric cancer inducing carcinogen N-methyl-N'-nitro-N-nitrosoguanidine and its role in mutagenesis.Human DNA polymerase-eta, an A-T mutator in somatic hypermutation of rearranged immunoglobulin genes, is a reverse transcriptase.Estrogen receptors bind to and activate the HOXC4/HoxC4 promoter to potentiate HoxC4-mediated activation-induced cytosine deaminase induction, immunoglobulin class switch DNA recombination, and somatic hypermutationDNA polymerases and somatic hypermutation of immunoglobulin genesInvolvement of Rad18 in somatic hypermutationEmerging links between hypermutation of antibody genes and DNA polymerases.DNA polymerase eta is the sole contributor of A/T modifications during immunoglobulin gene hypermutation in the mouse.The roles of REV3 and RAD57 in double-strand-break-repair-induced mutagenesis of Saccharomyces cerevisiae.p21 is dispensable for AID-mediated class switch recombination and mutagenesis of immunoglobulin genes during somatic hypermutation.AID and mismatch repair in antibody diversification.Accessibility control and machinery of immunoglobulin class switch recombination.Lupus-prone MRL/faslpr/lpr mice display increased AID expression and extensive DNA lesions, comprising deletions and insertions, in the immunoglobulin locus: concurrent upregulation of somatic hypermutation and class switch DNA recombination.Requirement for autophagy in the long-term persistence but not initial formation of memory B cells.What role for AID: mutator, or assembler of the immunoglobulin mutasome?Immunoglobulin somatic hypermutation: double-strand DNA breaks, AID and error-prone DNA repair.Mismatch-mediated error prone repair at the immunoglobulin genes.Germinal center-associated nuclear protein contributes to affinity maturation of B cell antigen receptor in T cell-dependent responses.Known components of the immunoglobulin A:T mutational machinery are intact in Burkitt lymphoma cell lines with G:C biasAltered Ig hypermutation pattern and frequency in complementary mouse models of DNA polymerase ζ activity.Hyper-immunoglobulin M syndromes caused by intrinsic B-lymphocyte defects.DNA polymerase ζ generates tandem mutations in immunoglobulin variable regions
P2860
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P2860
The translesion DNA polymerase zeta plays a major role in Ig and bcl-6 somatic hypermutation.
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年論文
@yue
2001年論文
@zh-hant
2001年論文
@zh-hk
2001年論文
@zh-mo
2001年論文
@zh-tw
2001年论文
@wuu
2001年论文
@zh
2001年论文
@zh-cn
name
The translesion DNA polymerase ...... d bcl-6 somatic hypermutation.
@ast
The translesion DNA polymerase ...... d bcl-6 somatic hypermutation.
@en
type
label
The translesion DNA polymerase ...... d bcl-6 somatic hypermutation.
@ast
The translesion DNA polymerase ...... d bcl-6 somatic hypermutation.
@en
prefLabel
The translesion DNA polymerase ...... d bcl-6 somatic hypermutation.
@ast
The translesion DNA polymerase ...... d bcl-6 somatic hypermutation.
@en
P2093
P2860
P1433
P1476
The translesion DNA polymerase ...... nd bcl-6 somatic hypermutation
@en
P2093
P2860
P304
P356
10.1016/S1074-7613(01)00142-X
P407
P577
2001-05-01T00:00:00Z