Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3
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Specific activation of leukocyte beta2 integrins lymphocyte function-associated antigen-1 and Mac-1 by chemokines mediated by distinct pathways via the alpha subunit cytoplasmic domainsOligomerization of the integrin alphaIIbbeta3: roles of the transmembrane and cytoplasmic domainsCoordinate interactions of Csk, Src, and Syk kinases with [alpha]IIb[beta]3 initiate integrin signaling to the cytoskeletonDisruption of focal adhesions by integrin cytoplasmic domain-associated protein-1 alphaMegakaryocytes derived from embryonic stem cells implicate CalDAG-GEFI in integrin signaling.The talin head domain reinforces integrin-mediated adhesion by promoting adhesion complex stability and clusteringAtomic Basis for the Species-specific Inhibition of V Integrins by Monoclonal Antibody 17E6 Is Revealed by the Crystal Structure of V 3 Ectodomain-17E6 Fab ComplexAssociation of the membrane proximal regions of the alpha and beta subunit cytoplasmic domains constrains an integrin in the inactive stateLateral clustering of platelet GP Ib-IX complexes leads to up-regulation of the adhesive function of integrin alpha IIbbeta 3Green fluorescent protein (GFP) tagged to the cytoplasmic tail of alphaIIb or beta3 allows the expression of a fully functional integrin alphaIIb(beta3): effect of beta3GFP on alphaIIb(beta3) ligand bindingActivation of integrins in endothelial cells by fluid shear stress mediates Rho-dependent cytoskeletal alignmentSimulations of cell-surface integrin binding to nanoscale-clustered adhesion ligands.Integrin leukocyte function-associated antigen-1-mediated cell binding can be activated by clustering of membrane raftsControlled dimerization of ErbB receptors provides evidence for differential signaling by homo- and heterodimersPrimary megakaryocytes reveal a role for transcription factor NF-E2 in integrin alpha IIb beta 3 signalingEvidence that distinct states of the integrin alpha6beta1 interact with laminin and an ADAM.Ligand density dramatically affects integrin alpha IIb beta 3-mediated platelet signaling and spreading.The small Rho GTPase Cdc42 regulates neutrophil polarity via CD11b integrin signalingBinding strength and activation state of single fibrinogen-integrin pairs on living cells.Cytosolic free Ca(2+) changes and calpain activation are required for beta integrin-accelerated phagocytosis by human neutrophils.The molecular adapter SLP-76 relays signals from platelet integrin alphaIIbbeta3 to the actin cytoskeleton.The GPIIb/IIIa (integrin alphaIIbbeta3) odyssey: a technology-driven saga of a receptor with twists, turns, and even a bend.Targeting integrin and integrin signaling in treating thrombosis.Cytoskeletal perturbation leads to platelet dysfunction and thrombocytopenia in variant forms of Glanzmann thrombastheniaIntegrin alphaIIbbeta3 activation in Chinese hamster ovary cells and platelets increases clustering rather than affinityADAP interactions with talin and kindlin promote platelet integrin αIIbβ3 activation and stable fibrinogen binding.Culture of K562 human myeloid leukemia cells in presence of fibronectin expresses and secretes MMP-9 in serum-free culture medium.A push-pull mechanism for regulating integrin function.G(12/13) signaling pathways substitute for integrin αIIbβ3-signaling for thromboxane generation in platelets.Cell adhesion strengthening: contributions of adhesive area, integrin binding, and focal adhesion assemblyL718P mutation in the membrane-proximal cytoplasmic tail of beta 3 promotes abnormal alpha IIb beta 3 clustering and lipid microdomain coalescence, and associates with a thrombasthenia-like phenotypeNoninvasive measurements of integrin microclustering under altered membrane cholesterol levels.Migfilin and filamin as regulators of integrin activation in endothelial cells and neutrophils.Intermolecular transmembrane domain interactions activate integrin αIIbβ3.Excess fibrinogen adsorption to monolayers of mixed lipids.Cross-linking of cell surface receptors enhances cooperativity of molecular adhesionBeta-1 integrin-mediated adhesion may be initiated by multiple incomplete bonds, thus accounting for the functional importance of receptor clustering.The role of the adapter molecule SLP-76 in platelet function.Tests of integrin transmembrane domain homo-oligomerization during integrin ligand binding and signalingP-selectin glycoprotein ligand-1 forms dimeric interactions with E-selectin but monomeric interactions with L-selectin on cell surfaces.
P2860
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P2860
Complementary roles for receptor clustering and conformational change in the adhesive and signaling functions of integrin alphaIIb beta3
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Complementary roles for recept ...... ons of integrin alphaIIb beta3
@ast
Complementary roles for recept ...... ons of integrin alphaIIb beta3
@en
type
label
Complementary roles for recept ...... ons of integrin alphaIIb beta3
@ast
Complementary roles for recept ...... ons of integrin alphaIIb beta3
@en
prefLabel
Complementary roles for recept ...... ons of integrin alphaIIb beta3
@ast
Complementary roles for recept ...... ons of integrin alphaIIb beta3
@en
P2093
P2860
P356
P1476
Complementary roles for recept ...... ons of integrin alphaIIb beta3
@en
P2093
P2860
P304
P356
10.1083/JCB.141.7.1685
P407
P577
1998-06-01T00:00:00Z