Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast.
about
MEC3, MEC1, and DDC2 are essential components of a telomere checkpoint pathway required for cell cycle arrest during senescence in Saccharomyces cerevisiae.Pol12, the B subunit of DNA polymerase alpha, functions in both telomere capping and length regulation.Yeast telomerase is specialized for C/A-rich RNA templates.A Trypanosoma brucei protein complex that binds G-overhangs and co-purifies with telomerase activity.Telomeres and telomerase.Identification and characterization of bovine regulator of telomere length elongation helicase gene (RTEL): molecular cloning, expression distribution, splice variants and DNA methylation profile.CTC1 increases the radioresistance of human melanoma cells by inhibiting telomere shortening and apoptosisTelomerase RNA template mutations reveal sequence-specific requirements for the activation and repression of telomerase action at telomeres.Intrachromatid excision of telomeric DNA as a mechanism for telomere size control in Saccharomyces cerevisiae.Molecular basis for telomere repeat divergence in budding yeastTelomere formation by rap1p binding site arrays reveals end-specific length regulation requirements and active telomeric recombination.A mutation in the STN1 gene triggers an alternative lengthening of telomere-like runaway recombinational telomere elongation and rapid deletion in yeast.Telomeric protein distributions and remodeling through the cell cycle in Saccharomyces cerevisiae.Telomere length, telomere-binding proteins, and DNA damage signaling.Telomere fusions caused by mutating the terminal region of telomeric DNAA novel pseudoknot element is essential for the action of a yeast telomerase.Telomerase and its potential for therapeutic intervention.A low threshold level of expression of mutant-template telomerase RNA inhibits human tumor cell proliferationTelomere uncapping by the G-quadruplex ligand RHPS4 inhibits clonogenic tumour cell growth in vitro and in vivo consistent with a cancer stem cell targeting mechanism.Genetic dissection of the Kluyveromyces lactis telomere and evidence for telomere capping defects in TER1 mutants with long telomeres.Role for telomere cap structure in meiosis.Mutant telomere sequences lead to impaired chromosome separation and a unique checkpoint response.Telomerase can inhibit the recombination-based pathway of telomere maintenance in human cells.Expression of mutant telomerase in immortal telomerase-negative human cells results in cell cycle deregulation, nuclear and chromosomal abnormalities and rapid loss of viability.Targeting telomeric G-quadruplexes with the ruthenium(II) complexes [Ru(bpy)(2)(ptpn)](2+) and [Ru(phen)(2)(ptpn)](2+)."Poisoning" yeast telomeres distinguishes between redundant telomere capping pathways.
P2860
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P2860
Uncapping and deregulation of telomeres lead to detrimental cellular consequences in yeast.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年論文
@yue
1999年論文
@zh-hant
1999年論文
@zh-hk
1999年論文
@zh-mo
1999年論文
@zh-tw
1999年论文
@wuu
1999年论文
@zh
1999年论文
@zh-cn
name
Uncapping and deregulation of ...... ellular consequences in yeast.
@ast
Uncapping and deregulation of ...... ellular consequences in yeast.
@en
type
label
Uncapping and deregulation of ...... ellular consequences in yeast.
@ast
Uncapping and deregulation of ...... ellular consequences in yeast.
@en
prefLabel
Uncapping and deregulation of ...... ellular consequences in yeast.
@ast
Uncapping and deregulation of ...... ellular consequences in yeast.
@en
P2860
P356
P1476
Uncapping and deregulation of ...... ellular consequences in yeast.
@en
P2093
P2860
P304
P356
10.1083/JCB.145.2.203
P407
P577
1999-04-01T00:00:00Z