Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts
about
Molecular features of the viral and cellular Src kinases involved in interactions with the GTPase-activating protein.Retroviral oncogenes: a historical primerTransforming properties of YAP, a candidate oncogene on the chromosome 11q22 ampliconThe hunting of the SrcCysteine residues in the C-terminal lobe of Src: their role in the suppression of the Src kinase.v-Src suppresses SHPS-1 expression via the Ras-MAP kinase pathway to promote the oncogenic growth of cells.SH3 domains specifically regulate kinase activity of expressed Src family proteins.Activation of c-Src in cells bearing v-Crk and its suppression by CskEffects of SH2 and SH3 deletions on the functional activities of wild-type and transforming variants of c-Src.Biological and biochemical activity of v-Crk chimeras containing the SH2/SH3 regions of phosphatidylinositol-specific phospholipase C-gamma and Src.Identification and characterization of a novel cytoskeleton-associated pp60src substrate.Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins.Deletions in the SH2 domain of p60v-src prevent association with the detergent-insoluble cellular matrixMutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformationActivation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteinsTransformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene.Association of p60src with Triton X-100-resistant cellular structure correlates with morphological transformation.Rous sarcoma virus variants that encode src proteins with an altered carboxy terminus are defective for cellular transformation.N-terminal mutations activate the leukemogenic potential of the myristoylated form of c-ablIsolation and characterization of fra-2, an additional member of the fos gene family.The function of activity-regulated genes in the nervous system.A retroviral promoter is sufficient to convert proto-src to a transforming gene that is distinct from the src gene of Rous sarcoma virus.Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.Specific transforming potential of oncogenes encoding protein-tyrosine kinasesGene transfer into chicken embryos by retrovirus vectors.Selected glimpses into the activation and function of Src kinase.Activation of transforming potential of the human insulin receptor geneHuman cellular src gene: nucleotide sequence and derived amino acid sequence of the region coding for the carboxy-terminal two-thirds of pp60c-srcNH2-terminal sequences of two src proteins that cause aberrant transformationCharacterization of avian and viral p60src proteins expressed in yeastMaturation of the tyrosine kinase c-src as a kinase and as a substrate depends on the molecular chaperone Hsp90.Phosphorylation of tyrosine in the carboxyl-terminal tryptic peptide of pp60c-src.Activation of the transforming potential of p60c-src by a single amino acid changeConformational processing of oncogenic v-Src kinase by the molecular chaperone Hsp90.The road to Src.Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle-T antigen of polyomavirusDNA methylation and transcriptional controls of proviral DNA in avian sarcoma virus-transformed mammalian cells.Chondrocytes as a specific target of ectopic Fos expression in early developmentImmunolocalization of the cellular src protein in interphase and mitotic NIH c-src overexpresser cells.
P2860
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P2860
Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts
description
1984 nî lūn-bûn
@nan
1984年の論文
@ja
1984年学术文章
@wuu
1984年学术文章
@zh-cn
1984年学术文章
@zh-hans
1984年学术文章
@zh-my
1984年学术文章
@zh-sg
1984年學術文章
@yue
1984年學術文章
@zh
1984年學術文章
@zh-hant
name
Rous sarcoma virus variants th ...... orm chicken embryo fibroblasts
@ast
Rous sarcoma virus variants th ...... orm chicken embryo fibroblasts
@en
type
label
Rous sarcoma virus variants th ...... orm chicken embryo fibroblasts
@ast
Rous sarcoma virus variants th ...... orm chicken embryo fibroblasts
@en
prefLabel
Rous sarcoma virus variants th ...... orm chicken embryo fibroblasts
@ast
Rous sarcoma virus variants th ...... orm chicken embryo fibroblasts
@en
P2093
P2860
P356
P1476
Rous sarcoma virus variants th ...... orm chicken embryo fibroblasts
@en
P2093
P2860
P304
P356
10.1073/PNAS.81.14.4424
P407
P577
1984-07-01T00:00:00Z