Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation
about
A cdc15-like adaptor protein (CD2BP1) interacts with the CD2 cytoplasmic domain and regulates CD2-triggered adhesion.The product of the cbl oncogene forms stable complexes in vivo with endogenous Crk in a tyrosine phosphorylation-dependent mannerTwo signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptorA novel signaling molecule, p130, forms stable complexes in vivo with v-Crk and v-Src in a tyrosine phosphorylation-dependent mannerThe WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modulesThe human GRB2 and Drosophila Drk genes can functionally replace the Caenorhabditis elegans cell signaling gene sem-5.c-Abl kinase regulates the protein binding activity of c-CrkMultiple SH2-mediated interactions in v-src-transformed cells.Expression of the v-crk oncogene product in PC12 cells results in rapid differentiation by both nerve growth factor- and epidermal growth factor-dependent pathwaysTwo species of human CRK cDNA encode proteins with distinct biological activitiesIdentification of p130(cas) as a substrate for the cytosolic protein tyrosine phosphatase PTP-PEST.DOCK180, a major CRK-binding protein, alters cell morphology upon translocation to the cell membraneA p130Cas tyrosine phosphorylated substrate domain decoy disrupts v-crk signalingNuclear Translocation of Crk Adaptor Proteins by the Influenza A Virus NS1 Protein.Phosphorylation of Dok1 by Abl family kinases inhibits CrkI transforming activity.Models of crk adaptor proteins in cancer.Proteins that bind the Src homology 3 domain of CrkI have distinct roles in Crk transformationWee1-regulated apoptosis mediated by the crk adaptor protein in Xenopus egg extracts.v-Crk activates the phosphoinositide 3-kinase/AKT pathway in transformation.The adaptor protein Crk connects multiple cellular stimuli to the JNK signaling pathwayActivation of Rho-dependent cell spreading and focal adhesion biogenesis by the v-Crk adaptor protein.Downstream of Crk adaptor signaling pathway: activation of Jun kinase by v-Crk through the guanine nucleotide exchange protein C3G.A 31-amino-acid N-terminal extension regulates c-Crk binding to tyrosine-phosphorylated proteins.Identification and characterization of a high-affinity interaction between v-Crk and tyrosine-phosphorylated paxillin in CT10-transformed fibroblastsBoth the SH2 and SH3 domains of human CRK protein are required for neuronal differentiation of PC12 cells.The SH2- and SH3-containing Nck protein transforms mammalian fibroblasts in the absence of elevated phosphotyrosine levels.Activation of c-Src in cells bearing v-Crk and its suppression by CskBiological and biochemical activity of v-Crk chimeras containing the SH2/SH3 regions of phosphatidylinositol-specific phospholipase C-gamma and Src.Identification of domains of the v-crk oncogene product sufficient for association with phosphotyrosine-containing proteins.Src phosphorylates Cas on tyrosine 253 to promote migration of transformed cellsCaspase-mediated cleavage of p130cas in etoposide-induced apoptotic Rat-1 cells.Crk is required for apoptosis in Xenopus egg extracts.Perspective: Dynamics of receptor tyrosine kinase signaling complexesIntegrin-mediated activation of focal adhesion kinase is required for signaling to Jun NH2-terminal kinase and progression through the G1 phase of the cell cycle.Point mutations in the abl SH2 domain coordinately impair phosphotyrosine binding in vitro and transforming activity in vivo.The noncatalytic src homology region 2 segment of abl tyrosine kinase binds to tyrosine-phosphorylated cellular proteins with high affinity.Cytokine regulation of gap junction connectivity: an open-and-shut case or changing partners at the Nexus?
P2860
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P2860
Mutagenic analysis of the v-crk oncogene: requirement for SH2 and SH3 domains and correlation between increased cellular phosphotyrosine and transformation
description
1990 nî lūn-bûn
@nan
1990 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1990 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1990年の論文
@ja
1990年論文
@yue
1990年論文
@zh-hant
1990年論文
@zh-hk
1990年論文
@zh-mo
1990年論文
@zh-tw
1990年论文
@wuu
name
Mutagenic analysis of the v-cr ...... photyrosine and transformation
@ast
Mutagenic analysis of the v-cr ...... photyrosine and transformation
@en
type
label
Mutagenic analysis of the v-cr ...... photyrosine and transformation
@ast
Mutagenic analysis of the v-cr ...... photyrosine and transformation
@en
prefLabel
Mutagenic analysis of the v-cr ...... photyrosine and transformation
@ast
Mutagenic analysis of the v-cr ...... photyrosine and transformation
@en
P2860
P1433
P1476
Mutagenic analysis of the v-cr ...... photyrosine and transformation
@en
P2093
P2860
P304
P577
1990-08-01T00:00:00Z