Morphine-activated opioid receptors elude desensitization by beta-arrestin. - Wikidata - awgldk - TriplyDB

Morphine-activated opioid receptors elude desensitization by beta-arrestin.

Morphine-activated opioid receptors elude desensitization by beta-arrestin.

http://www.wikidata.org/entity/Q36280218

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Morphine induces endocytosis of neuronal mu-opioid receptors through the sustained transfer of Galpha subunits to RGSZ2 proteins Regulation of mu opioid receptor internalization by the scaffold protein RanBPM A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers.Beta-arrestin-dependent mu-opioid receptor-activated extracellular signal-regulated kinases (ERKs) Translocate to Nucleus in Contrast to G protein-dependent ERK activation Morphine-induced physiological and behavioral responses in mice lacking G protein-coupled receptor kinase 6 The analgesic efficacy of fentanyl: relationship to tolerance and mu-opioid receptor regulation Essential role for RGS9 in opiate action Neurokinin 1 receptors regulate morphine-induced endocytosis and desensitization of mu-opioid receptors in CNS neurons Multiple endocytic pathways of G protein-coupled receptors delineated by GIT1 sensitivity The emerging roles of β-arrestins in fibrotic diseases Heterologous activation of protein kinase C stimulates phosphorylation of delta-opioid receptor at serine 344, resulting in beta-arrestin- and clathrin-mediated receptor internalization Beta-arrestins: multifunctional cellular mediators Multiple actions of spinophilin regulate mu opioid receptor function Activation of mu opioid receptors sensitizes transient receptor potential vanilloid type 1 (TRPV1) via β-arrestin-2-mediated cross-talk Identification of the First Marine-Derived Opioid Receptor "Balanced" Agonist with a Signaling Profile That Resembles the Endorphins Proteasome involvement in agonist-induced down-regulation of mu and delta opioid receptors.High-affinity naloxone binding to filamin a prevents mu opioid receptor-Gs coupling underlying opioid tolerance and dependence.Brain region-specific N-glycosylation and lipid rafts association of the rat mu opioid receptor G-protein coupled receptor kinases as modulators of G-protein signalling.Agonist-dependent mu-opioid receptor signaling can lead to heterologous desensitization.beta-Arrestin2, interacting with phosphodiesterase 4, regulates synaptic release probability and presynaptic inhibition by opioids.Chronic ethanol consumption in rats produces opioid antinociceptive tolerance through inhibition of mu opioid receptor endocytosis.Mutational analysis of the structure and function of opioid receptors.Phosphorylation of EEA1 by p38 MAP kinase regulates mu opioid receptor endocytosis.Structure and regulation of opioid receptors.How to design an opioid drug that causes reduced tolerance and dependence.Receptors and transmission in the brain-gut axis: potential for novel therapies. III. Mu-opioid receptors in the enteric nervous system.The role of beta-arrestin2 in the severity of antinociceptive tolerance and physical dependence induced by different opioid pain therapeutics.Opioid-induced mitogen-activated protein kinase signaling in rat enteric neurons following chronic morphine treatment.Examining the role of mu opioid receptor endocytosis in the beneficial and side-effects of prolonged opioid use: from a symposium on new concepts in mu-opioid pharmacology Chronic morphine treatment attenuates cell growth of human BT474 breast cancer cells by rearrangement of the ErbB signalling network.Morphine induces μ opioid receptor endocytosis in guinea pig enteric neurons following prolonged receptor activation An opioid agonist that does not induce mu-opioid receptor--arrestin interactions or receptor internalization.Opioid receptor desensitization: mechanisms and its link to tolerance Functional selectivity and time-dependence of μ-opioid receptor desensitization at nerve terminals in the mouse ventral tegmental area Change in functional selectivity of morphine with the development of antinociceptive tolerance.Heteromerization of the μ- and δ-opioid receptors produces ligand-biased antagonism and alters μ-receptor trafficking Co-expression of GRK2 reveals a novel conformational state of the µ-opioid receptor Cholesterol regulates micro-opioid receptor-induced beta-arrestin 2 translocation to membrane lipid rafts.Effect of KEPI (Ppp1r14c) deletion on morphine analgesia and tolerance in mice of different genetic backgrounds: when a knockout is near a relevant quantitative trait locus.

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P2860

Morphine-activated opioid receptors elude desensitization by beta-arrestin.

http://www.wikidata.org/entity/Q36280218

description

1998 nî lūn-bûn

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1998年の論文

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年学术文章

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1998年學術文章

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1998年學術文章

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1998年學術文章

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name

Morphine-activated opioid receptors elude desensitization by beta-arrestin.

@ast

Morphine-activated opioid receptors elude desensitization by beta-arrestin.

@en

type

label

Morphine-activated opioid receptors elude desensitization by beta-arrestin.

@ast

Morphine-activated opioid receptors elude desensitization by beta-arrestin.

@en

prefLabel

Morphine-activated opioid receptors elude desensitization by beta-arrestin.

@ast

Morphine-activated opioid receptors elude desensitization by beta-arrestin.

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Proceedings of the National Academy of Sciences of the United States of America

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Morphine-activated opioid receptors elude desensitization by beta-arrestin.

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J L Whistler

http://www.w3.org/2001/XMLSchema#string

M von Zastrow

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P2860

beta-Arrestin: a protein that regulates beta-adrenergic receptor function

A beta-arrestin/green fluorescent protein biosensor for detecting G protein-coupled receptor activation

Opiate receptor knockout mice define mu receptor roles in endogenous nociceptive responses and morphine-induced analgesia

Beta-arrestin acts as a clathrin adaptor in endocytosis of the beta2-adrenergic receptor

Induction of mutant dynamin specifically blocks endocytic coated vesicle formation

Effects of mutant rat dynamin on endocytosis.

Role for G protein-coupled receptor kinase in agonist-specific regulation of mu-opioid receptor responsiveness

Agonist-selective endocytosis of mu opioid receptor by neurons in vivo.

Opioid receptors and the regulation of ion conductances.

mu-Opioid receptor internalization: opiate drugs have differential effects on a conserved endocytic mechanism in vitro and in the mammalian brain.

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9914-9919

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