Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats
about
Protection against sepsis-induced lung injury by selective inhibition of protein kinase C-δ (δ-PKC)Interleukin-25 expressed by brain capillary endothelial cells maintains blood-brain barrier function in a protein kinase Cepsilon-dependent manner.PKC-δ isoform plays a crucial role in Tat-TLR4 signalling pathway to activate NF-κB and CXCL8 productionAberrant mitochondrial fission in neurons induced by protein kinase C{delta} under oxidative stress conditions in vivo.Mechanisms underlying the cerebral microvascular responses to angiotensin II-induced hypertension.Protein kinase Cδ mediates histamine-evoked itch and responses in pruriceptorsβIIPKC and εPKC isozymes as potential pharmacological targets in cardiac hypertrophy and heart failureInhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancerHypertonic/hyperoncotic solution attenuate blood-brain barrier breakdown and brain pathology in whole body hyperthermia ratsMitochondrial reactive oxygen species at the heart of the matter: new therapeutic approaches for cardiovascular diseases.Ghrelin prevents disruption of the blood-brain barrier after traumatic brain injury.Biodistribution and Efficacy of Targeted Pulmonary Delivery of a Protein Kinase C-δ Inhibitory Peptide: Impact on Indirect Lung Injury.Pharmacological inhibition of βIIPKC is cardioprotective in late-stage hypertrophy.Learning on Jupiter, learning on the Moon: the dark side of the G-force. Effects of gravity changes on neurovascular unit and modulation of learning and memoryBryostatin extends tPA time window to 6 h following middle cerebral artery occlusion in aged female rats.Genetic disruption of protein kinase Cδ reduces endotoxin-induced lung injury.A novel Drp1 inhibitor diminishes aberrant mitochondrial fission and neurotoxicity.Hypothalamic protein kinase C regulates glucose production.Mast cells and epsilonPKC: a role in cardiac remodeling in hypertension-induced heart failure.Protein kinase C, an elusive therapeutic target?Selective Phosphorylation Inhibitor of Delta Protein Kinase C-Pyruvate Dehydrogenase Kinase Protein-Protein Interactions: Application for Myocardial Injury in Vivo.Inhibition of mitochondrial fragmentation diminishes Huntington's disease-associated neurodegeneration.The many hats of protein kinase Cδ: one enzyme with many functions.Cerebral Vascular Disease and Neurovascular Injury in Ischemic Stroke.Hypertensive encephalopathy and the blood-brain barrier: is deltaPKC a gatekeeper?Engineered Substrate-Specific Delta PKC Antagonists to Enhance Cardiac Therapeutics.Inhibition of Drp1/Fis1 interaction slows progression of amyotrophic lateral sclerosis.Dapsone protects brain microvascular integrity from high-fat diet induced LDL oxidation.
P2860
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P2860
Sustained pharmacological inhibition of deltaPKC protects against hypertensive encephalopathy through prevention of blood-brain barrier breakdown in rats
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
Sustained pharmacological inhi ...... rain barrier breakdown in rats
@ast
Sustained pharmacological inhi ...... rain barrier breakdown in rats
@en
type
label
Sustained pharmacological inhi ...... rain barrier breakdown in rats
@ast
Sustained pharmacological inhi ...... rain barrier breakdown in rats
@en
prefLabel
Sustained pharmacological inhi ...... rain barrier breakdown in rats
@ast
Sustained pharmacological inhi ...... rain barrier breakdown in rats
@en
P2093
P2860
P356
P1476
Sustained pharmacological inhi ...... rain barrier breakdown in rats
@en
P2093
Koichi Inagaki
Raymond A Sobel
P2860
P304
P356
10.1172/JCI32636
P407
P577
2008-01-01T00:00:00Z