Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer - Wikidata - awgldk - TriplyDB

Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer

Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer

http://www.wikidata.org/entity/Q35572426

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Curtailing side effects in chemotherapy: a tale of PKCδ in cisplatin treatment Programmed necrosis in acute kidney injury Heat shock protein 72 suppresses apoptosis by increasing the stability of X-linked inhibitor of apoptosis protein in renal ischemia/reperfusion injury Isoalantolactone inhibits UM-SCC-10A cell growth via cell cycle arrest and apoptosis induction Cellular and Molecular Mechanisms of AKI.Inhibiting tyrosine phosphorylation of protein kinase Cδ (PKCδ) protects the salivary gland from radiation damage Pharmacological inhibition of Src kinase protects against acute kidney injury in a murine model of renal ischemia/reperfusion.Cisplatin-induced renal injury is independently mediated by OCT2 and p53.Differential and conditional activation of PKC-isoforms dictates cardiac adaptation during physiological to pathological hypertrophy.Pathophysiology of cisplatin-induced acute kidney injury.Tubular p53 regulates multiple genes to mediate AKI Regulated cell death in AKI.Mitochondrial dysregulation and protection in cisplatin nephrotoxicity.Protein kinase Cδ mediates histamine-evoked itch and responses in pruriceptors SUMOylation occurs in acute kidney injury and plays a cytoprotective role Mitochondrial-targeted antioxidants represent a promising approach for prevention of cisplatin-induced nephropathy Reciprocal regulation of cilia and autophagy via the MTOR and proteasome pathways.Biodistribution and Efficacy of Targeted Pulmonary Delivery of a Protein Kinase C-δ Inhibitory Peptide: Impact on Indirect Lung Injury.DNA damage response in cisplatin-induced nephrotoxicity.Repeated administration of low-dose cisplatin in mice induces fibrosis.A potential adjuvant chemotherapeutics, 18β-glycyrrhetinic acid, inhibits renal tubular epithelial cells apoptosis via enhancing BMP-7 epigenetically through targeting HDAC2.Genetic disruption of Abl nuclear import reduces renal apoptosis in a mouse model of cisplatin-induced nephrotoxicity In Vitro Neutrophil Migration Requires Protein Kinase C-Delta (δ-PKC)-Mediated Myristoylated Alanine-Rich C-Kinase Substrate (MARCKS) Phosphorylation.Bridging translation for acute kidney injury with better preclinical modeling of human disease ERK-mediated suppression of cilia in cisplatin-induced tubular cell apoptosis and acute kidney injury.Increasing cGMP-dependent protein kinase I activity attenuates cisplatin-induced kidney injury through protection of mitochondria function Role of CFTR in oxidative stress and suicidal death of renal cells during cisplatin-induced nephrotoxicity.Neuropeptide Y protects kidney against cisplatin-induced nephrotoxicity by regulating p53-dependent apoptosis pathway.Renoprotective approaches and strategies in acute kidney injury Cisplatin-induced nephrotoxicity and targets of nephroprotection: an update.Signalling mechanisms involved in renal pathological changes during cisplatin-induced nephropathy.Role of annexin A5 in cisplatin-induced toxicity in renal cells: molecular mechanism of apoptosis.Protein kinase C-delta (PKCδ), a marker of inflammation and tuberculosis disease progression in humans, is important for optimal macrophage killing effector functions and survival in mice.Multifunctional roles of PKCδ: Opportunities for targeted therapy in human disease Magnesium protects against cisplatin-induced acute kidney injury without compromising cisplatin-mediated killing of an ovarian tumor xenograft in mice.Necroptosis-inducing rhenium(V) oxo complexes.DNA damage response in nephrotoxic and ischemic kidney injury.Cyclotherapy: opening a therapeutic window in cancer treatment.Pseudolaric Acid B induces caspase-dependent and caspase-independent apoptosis in u87 glioblastoma cells.Identification of OAT1/OAT3 as Contributors to Cisplatin Toxicity.

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P2860

Inhibition of PKCδ reduces cisplatin-induced nephrotoxicity without blocking chemotherapeutic efficacy in mouse models of cancer

http://www.wikidata.org/entity/Q35572426

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Journal of Clinical Investigation

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Guie Dong

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M Vijay Kumar

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Man Jiang

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Navjotsingh Pabla

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Robert O Messing

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Zheng Dong

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P2860

Protein kinase C delta regulates Ser46 phosphorylation of p53 tumor suppressor in the apoptotic response to DNA damage

Curing metastatic testicular cancer

Mechanisms of Cisplatin nephrotoxicity

Regulation of cell apoptosis by protein kinase c delta

ATR-Chk2 signaling in p53 activation and DNA damage response during cisplatin-induced apoptosis

Proteolytic activation of protein kinase C delta by an ICE/CED 3-like protease induces characteristics of apoptosis

Cisplatin: mode of cytotoxic action and molecular basis of resistance

Principles of cancer therapy: oncogene and non-oncogene addiction

Cellular processing of platinum anticancer drugs

Regulation of mitochondrial dynamics in acute kidney injury in cell culture and rodent models.

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