Alu elements mediate MYB gene tandem duplication in human T-ALL
about
New tricks from an old oncogene: gene fusion and copy number alterations of MYB in human cancerBreakpoint analysis of transcriptional and genomic profiles uncovers novel gene fusions spanning multiple human cancer typesRoles of retrotransposons in benign and malignant hematologic disease.Inactivation of LEF1 in T-cell acute lymphoblastic leukemia.Alu distribution and mutation types of cancer genes.A mobile threat to genome stability: The impact of non-LTR retrotransposons upon the human genome.All y'all need to know 'bout retroelements in cancer.Single-stranded annealing induced by re-initiation of replication origins provides a novel and efficient mechanism for generating copy number expansion via non-allelic homologous recombination.Integrated genome-wide chromatin occupancy and expression analyses identify key myeloid pro-differentiation transcription factors repressed by MybComprehensive analysis of transcriptome variation uncovers known and novel driver events in T-cell acute lymphoblastic leukemiaA unifying gene signature for adenoid cystic cancer identifies parallel MYB-dependent and MYB-independent therapeutic targets.Regulatory mechanisms that prevent re-initiation of DNA replication can be locally modulated at origins by nearby sequence elements.Alu-mediated diverse and complex pathogenic copy-number variants within human chromosome 17 at p13.3.Modes of retrotransposition of long interspersed element-1 by environmental factors.Core transcriptional regulatory circuit controlled by the TAL1 complex in human T cell acute lymphoblastic leukemia.Impaired adult myeloid progenitor CMP and GMP cell function in conditional c-myb-knockout miceTransposable Elements in Human Cancer: Causes and Consequences of DeregulationMyb proteins: angels and demons in normal and transformed cells.TYK2-STAT1-BCL2 pathway dependence in T-cell acute lymphoblastic leukemiaThe NOTCH signaling pathway: role in the pathogenesis of T-cell acute lymphoblastic leukemia and implication for therapy.Analysis of LMNB1 duplications in autosomal dominant leukodystrophy provides insights into duplication mechanisms and allele-specific expression.Acquired copy number alterations in adult acute myeloid leukemia genomes.WT1 mutations in T-ALLStress-induced phosphorylation of Thr486 in c-Myb by p38 mitogen-activated protein kinases attenuates conjugation of SUMO-2/3KPT-330 inhibitor of CRM1 (XPO1)-mediated nuclear export has selective anti-leukaemic activity in preclinical models of T-cell acute lymphoblastic leukaemia and acute myeloid leukaemia.Molecular pathogenesis and targeted therapies for NOTCH1-induced T-cell acute lymphoblastic leukemia.Role and potential for therapeutic targeting of MYB in leukemia.The molecular basis of T cell acute lymphoblastic leukemiaThe MYB proto-oncogene suppresses monocytic differentiation of acute myeloid leukemia cells via transcriptional activation of its target gene GFI1.Alu-Alu fusion sequences identified at junction sites of copy number amplified regions in cancer cell lines.miR-150 Regulates Memory CD8 T Cell Differentiation via c-Myb.Loss of DNA replication control is a potent inducer of gene amplification.Zebrafish microRNA-126 determines hematopoietic cell fate through c-Myb.RUNX1 is required for oncogenic Myb and Myc enhancer activity in T-cell acute lymphoblastic leukemia.ARID5B as a critical downstream target of the TAL1 complex that activates the oncogenic transcriptional program and promotes T-cell leukemogenesis.Mammalian transposable elements and their impacts on genome evolution.An alternative approach to medical genetics based on modern evolutionary biology. Part 4: HERVs in cancer.Mobile Elements in the Human Genome: Implications for Disease
P2860
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P2860
Alu elements mediate MYB gene tandem duplication in human T-ALL
description
2007 nî lūn-bûn
@nan
2007年の論文
@ja
2007年学术文章
@wuu
2007年学术文章
@zh-cn
2007年学术文章
@zh-hans
2007年学术文章
@zh-my
2007年学术文章
@zh-sg
2007年學術文章
@yue
2007年學術文章
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2007年學術文章
@zh-hant
name
Alu elements mediate MYB gene tandem duplication in human T-ALL
@ast
Alu elements mediate MYB gene tandem duplication in human T-ALL
@en
type
label
Alu elements mediate MYB gene tandem duplication in human T-ALL
@ast
Alu elements mediate MYB gene tandem duplication in human T-ALL
@en
prefLabel
Alu elements mediate MYB gene tandem duplication in human T-ALL
@ast
Alu elements mediate MYB gene tandem duplication in human T-ALL
@en
P2093
P2860
P50
P356
P1476
Alu elements mediate MYB gene tandem duplication in human T-ALL
@en
P2093
A Thomas Look
Charles Lee
Daniel J DeAngelo
Donna Neuberg
Jeffery L Kutok
Jennifer O'Neil
Joelle Tchinda
Keith McKenna
Lewis Silverman
P2860
P304
P356
10.1084/JEM.20071637
P407
P577
2007-12-10T00:00:00Z