Computer-aided lead optimization: improved small-molecule inhibitor of the zinc endopeptidase of botulinum neurotoxin serotype A
about
Potent new small-molecule inhibitor of botulinum neurotoxin serotype A endopeptidase developed by synthesis-based computer-aided molecular designSmall molecules showing significant protection of mice against botulinum neurotoxin serotype AMetal Ion Modeling Using Classical MechanicsIdentification of a Natural Product Antagonist against the Botulinum Neurotoxin Light Chain ProteaseSynthesis and evaluation of library of betulin derivatives against the botulinum neurotoxin A protease.Time-dependent botulinum neurotoxin serotype A metalloprotease inhibitors.Analysis of Botulinum Neurotoxin Serotype A Metalloprotease Inhibitors: Analogs of a Chemotype for Therapeutic Development in the Context of a Three-Zone PharmacophoreSmall-molecule quinolinol inhibitor identified provides protection against BoNT/A in mice.Basic tetrapeptides as potent intracellular inhibitors of type A botulinum neurotoxin protease activity.Determining the Functions of HIV-1 Tat and a Second Magnesium Ion in the CDK9/Cyclin T1 Complex: A Molecular Dynamics Simulation Study.Substrate-based inhibitors exhibiting excellent protective and therapeutic effects against Botulinum Neurotoxin A intoxicationConvenient Synthesis of a Library of Discrete Hydroxamic Acids Using the Hydroxythiophenol (Marshall) Resin.Identification and biochemical characterization of small-molecule inhibitors of Clostridium botulinum neurotoxin serotype ATargeting botulinum A cellular toxicity: a prodrug approach.Molecular structures and functional relationships in clostridial neurotoxins.Targeting bacterial toxins.Current strategies for designing antidotes against botulinum neurotoxins.Development of antivirulence compounds: a biochemical review.Investigating novel therapeutic targets and molecular mechanisms to treat botulinum neurotoxin A intoxication.
P2860
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P2860
Computer-aided lead optimization: improved small-molecule inhibitor of the zinc endopeptidase of botulinum neurotoxin serotype A
description
2007 nî lūn-bûn
@nan
2007 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Computer-aided lead optimizati ...... otulinum neurotoxin serotype A
@ast
Computer-aided lead optimizati ...... otulinum neurotoxin serotype A
@en
type
label
Computer-aided lead optimizati ...... otulinum neurotoxin serotype A
@ast
Computer-aided lead optimizati ...... otulinum neurotoxin serotype A
@en
prefLabel
Computer-aided lead optimizati ...... otulinum neurotoxin serotype A
@ast
Computer-aided lead optimizati ...... otulinum neurotoxin serotype A
@en
P2093
P2860
P1433
P1476
Computer-aided lead optimizati ...... otulinum neurotoxin serotype A
@en
P2093
Charles B Millard
James J Schmidt
Jewn Giew Park
P2860
P356
10.1371/JOURNAL.PONE.0000761
P407
P577
2007-08-22T00:00:00Z