Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma - Wikidata - awgldk - TriplyDB

Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma

Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma

http://www.wikidata.org/entity/Q36322562

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Induction of human beta-cell proliferation and engraftment using a single G1/S regulatory molecule, cdk6 Down-regulation of ubiquitin ligase Cbl induced by twist haploinsufficiency in Saethre-Chotzen syndrome results in increased PI3K/Akt signaling and osteoblast proliferation Heparanase expression and activity influences chondrogenic and osteogenic processes during endochondral bone formation Novel Implications of DNA Damage Response in Drug Resistance of Malignant Cancers Obtained from the Functional Interaction between p53 Family and RUNX2 MicroRNAs in the pathobiology of sarcomas Runx2 controls a feed-forward loop between androgen and prolactin-induced protein (PIP) in stimulating T47D cell proliferation The RUNX genes: gain or loss of function in cancer Wnt inhibitory factor 1 is epigenetically silenced in human osteosarcoma, and targeted disruption accelerates osteosarcomagenesis in mice Osteosarcomagenesis: modeling cancer initiation in the mouse.The transcription factor ATF3 is upregulated during chondrocyte differentiation and represses cyclin D1 and A gene transcription A novel RUNX2 missense mutation predicted to disrupt DNA binding causes cleidocranial dysplasia in a large Chinese family with hyperplastic nails.Expression of master regulatory genes controlling skeletal development in benign cartilage and bone forming tumors.Digital expression profiling identifies RUNX2, CDC5L, MDM2, RECQL4, and CDK4 as potential predictive biomarkers for neo-adjuvant chemotherapy response in paediatric osteosarcoma.Down-regulation of type I Runx2 mediated by dexamethasone is required for 3T3-L1 adipogenesis.Therapeutic Implications of PPARgamma in Human Osteosarcoma.E2F1 impairs all-trans retinoic acid-induced osteogenic differentiation of osteosarcoma via promoting ubiquitination-mediated degradation of RARα.SIRT1 is a positive regulator of the master osteoblast transcription factor, RUNX2.The bone-specific expression of Runx2 oscillates during the cell cycle to support a G1-related antiproliferative function in osteoblasts.The osteogenic transcription factor Runx2 regulates components of the fibroblast growth factor/proteoglycan signaling axis in osteoblasts Metastatic bone disease: role of transcription factors and future targets.Elevated expression of Runx2 as a key parameter in the etiology of osteosarcoma.Targeted apc;twist double-mutant mice: a new model of spontaneous osteosarcoma that mimics the human disease The Role of RUNX2 in Osteosarcoma Oncogenesis.Frequent attenuation of the WWOX tumor suppressor in osteosarcoma is associated with increased tumorigenicity and aberrant RUNX2 expression.Cell cycle regulator gene CDC5L, a potential target for 6p12-p21 amplicon in osteosarcoma CD99 drives terminal differentiation of osteosarcoma cells by acting as a spatial regulator of ERK 1/2.Runt-related transcription factor RUNX3 is a target of MDM2-mediated ubiquitination Defective osteogenic differentiation in the development of osteosarcoma.Cancer-related ectopic expression of the bone-related transcription factor RUNX2 in non-osseous metastatic tumor cells is linked to cell proliferation and motility Mitochondrial dysfunction in cancer cells due to aberrant mitochondrial replication.Hypoxia-inducible factor 1 is activated by dysregulated cyclin E during mammary epithelial morphogenesis.mTORC1 maintains the tumorigenicity of SSEA-4(+) high-grade osteosarcoma.The impact of osteoblastic differentiation on osteosarcomagenesis in the mouse.The Forkhead Transcription Factor FOXP2 Is Required for Regulation of p21WAF1/CIP1 in 143B Osteosarcoma Cell Growth Arrest.Opposing effects of Runx2 and estradiol on breast cancer cell proliferation: in vitro identification of reciprocally regulated gene signature related to clinical letrozole responsiveness CCN3 modulates bone turnover and is a novel regulator of skeletal metastasis Molecular and cellular mechanisms of the anabolic effect of intermittent PTH Osteoblast differentiation and skeletal development are regulated by Mdm2-p53 signaling Genetically engineered mouse models and human osteosarcoma.THE COP9 SIGNALOSOME, A NOVEL, ESSENTIAL REGULATOR OF SKELETAL DEVELOPMENT AND TUMORIGENESIS.

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P2860

Terminal osteoblast differentiation, mediated by runx2 and p27KIP1, is disrupted in osteosarcoma

http://www.wikidata.org/entity/Q36322562

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2004 nî lūn-bûn

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2004年の論文

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年学术文章

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2004年學術文章

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2004年學術文章

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2004年學術文章

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name

Terminal osteoblast differenti ...... , is disrupted in osteosarcoma

@ast

Terminal osteoblast differenti ...... , is disrupted in osteosarcoma

@en

type

label

Terminal osteoblast differenti ...... , is disrupted in osteosarcoma

@ast

Terminal osteoblast differenti ...... , is disrupted in osteosarcoma

@en

prefLabel

Terminal osteoblast differenti ...... , is disrupted in osteosarcoma

@ast

Terminal osteoblast differenti ...... , is disrupted in osteosarcoma

@en

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Journal of Cell Biology

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Terminal osteoblast differenti ...... , is disrupted in osteosarcoma

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Andrew J Holloway

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Brian P Rubin

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Bruce E Clurman

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Denise M Piscopo

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Dileepa Diyagama

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Grant A McArthur

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John L Slavin

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Jonathon E Grim

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Jong-Seo Lee

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Melanie K Trivett

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P2860

Bone morphogenetic protein 2-induced osteoblast differentiation requires Smad-mediated down-regulation of Cdk6

Mutations involving the transcription factor CBFA1 cause cleidocranial dysplasia

AML1, AML2, and AML3, the human members of the runt domain gene-family: cDNA structure, expression, and chromosomal localization

Oncogenic ras provokes premature cell senescence associated with accumulation of p53 and p16INK4a

A biomarker that identifies senescent human cells in culture and in aging skin in vivo

Normalization for cDNA microarray data: a robust composite method addressing single and multiple slide systematic variation.

CDK inhibitors: positive and negative regulators of G1-phase progression

Cbfa1, a candidate gene for cleidocranial dysplasia syndrome, is essential for osteoblast differentiation and bone development

Runx1/AML1 in leukemia: disrupted association with diverse protein partners

Osf2/Cbfa1: a transcriptional activator of osteoblast differentiation

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925-934

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10.1083/JCB.200409187

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5

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Gabriel M Gutierrez

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2004-12-01T00:00:00Z

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