Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.
about
Using genetic methods to define the targets of compounds with antimalarial activityAntimalarial drug discovery - approaches and progress towards new medicines.A genomic and evolutionary approach reveals non-genetic drug resistance in malariaMuddled mechanisms: recent progress towards antimalarial target identificationHigh-Throughput Luciferase-Based Assay for the Discovery of Therapeutics That Prevent MalariaParasites resistant to the antimalarial atovaquone fail to transmit by mosquitoesA Novel Methodology for Bioenergetic Analysis of Plasmodium falciparum Reveals a Glucose-Regulated Metabolic Shift and Enables Mode of Action Analyses of Mitochondrial Inhibitors.Emergence of resistance to atovaquone-proguanil in malaria parasites: insights from computational modeling and clinical case reportsDiversity-oriented synthesis probe targets Plasmodium falciparum cytochrome b ubiquinone reduction site and synergizes with oxidation site inhibitors.Saccharomyces cerevisiae-based mutational analysis of the bc1 complex Qo site residue 279 to study the trade-off between atovaquone resistance and function.Discovery of Dual-Stage Malaria Inhibitors with New Targets.Probing the Azaaurone Scaffold against the Hepatic and Erythrocytic Stages of Malaria Parasites.Sequence-based association and selection scans identify drug resistance loci in the Plasmodium falciparum malaria parasite.The cytoplasmic prolyl-tRNA synthetase of the malaria parasite is a dual-stage target of febrifugine and its analogs.A broad analysis of resistance development in the malaria parasitePlasmodium falciparum Cyclic Amine Resistance Locus (PfCARL), a Resistance Mechanism for Two Distinct Compound Classes.Exploration of 4(1H)-pyridones as a novel family of potent antimalarial inhibitors of the plasmodial cytochrome bc1.Novel inhibitors of the Plasmodium falciparum electron transport chain.Genetic diversity of next generation antimalarial targets: A baseline for drug resistance surveillance programmes.Exploring the Molecular Basis of Qo bc1 Complex Inhibitors Activity to Find Novel Antimalarials Hits.Mycobacterial Membrane Proteins QcrB and AtpE: Roles in Energetics, Antibiotic Targets, and Associated Mechanisms of Resistance.Identification of Collateral Sensitivity to Dihydroorotate Dehydrogenase Inhibitors in Plasmodium falciparum.Using in Vitro Evolution and Whole Genome Analysis To Discover Next Generation Targets for Antimalarial Drug Discovery.
P2860
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P2860
Identification and validation of tetracyclic benzothiazepines as Plasmodium falciparum cytochrome bc1 inhibitors.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年学术文章
@wuu
2011年学术文章
@zh-cn
2011年学术文章
@zh-hans
2011年学术文章
@zh-my
2011年学术文章
@zh-sg
2011年學術文章
@yue
2011年學術文章
@zh
2011年學術文章
@zh-hant
name
Identification and validation ...... rum cytochrome bc1 inhibitors.
@ast
Identification and validation ...... rum cytochrome bc1 inhibitors.
@en
type
label
Identification and validation ...... rum cytochrome bc1 inhibitors.
@ast
Identification and validation ...... rum cytochrome bc1 inhibitors.
@en
prefLabel
Identification and validation ...... rum cytochrome bc1 inhibitors.
@ast
Identification and validation ...... rum cytochrome bc1 inhibitors.
@en
P2093
P2860
P50
P1476
Identification and validation ...... rum cytochrome bc1 inhibitors.
@en
P2093
Adelfa E Serrano
Bradley I Coleman
Carolyn K Dong
Clary B Clish
Emily R Derbyshire
Francisco-Javier Gamo
Jeffrey D Dvorin
Jon Clardy
Joseph F Cortese
Leila Ross
P2860
P304
P356
10.1016/J.CHEMBIOL.2011.09.016
P577
2011-12-01T00:00:00Z