Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes.
about
Emerging roles of glycogen synthase kinase 3 in the treatment of brain tumorsThe broken "Off" switch in cancer signaling: PP2A as a regulator of tumorigenesis, drug resistance, and immune surveillanceMedulloblastoma: tumorigenesis, current clinical paradigm, and efforts to improve risk stratificationGSK3beta in ethanol neurotoxicityThe role of GSK3beta in the development of the central nervous systemGene expression profiling of a hypoxic seizure model of epilepsy suggests a role for mTOR and Wnt signaling in epileptogenesis.Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumorsConditional deletion of N-Myc disrupts neurosensory and non-sensory development of the ear.Mutational ataxia resulting from abnormal vestibular acquisition and processing is partially compensated forSystems biology by the rules: hybrid intelligent systems for pathway modeling and discovery.Regulation of sonic hedgehog-GLI1 downstream target genes PTCH1, Cyclin D2, Plakoglobin, PAX6 and NKX2.2 and their epigenetic status in medulloblastoma and astrocytoma.Huwe1 ubiquitin ligase is essential to synchronize neuronal and glial differentiation in the developing cerebellumDexamethasone destabilizes Nmyc to inhibit the growth of hedgehog-associated medulloblastomac-myc and N-myc promote active stem cell metabolism and cycling as architects of the developing brain.c- and N-myc regulate neural precursor cell fate, cell cycle, and metabolism to direct cerebellar development.Glucocorticoid treatment of MCMV infected newborn mice attenuates CNS inflammation and limits deficits in cerebellar development.p27(Kip1), a double-edged sword in Shh-mediated medulloblastoma: Tumor accelerator and suppressor.Non-redundant role for the transcription factor Gli1 at multiple stages of thymocyte development.Transcription factors with conserved binding sites near ATOH1 on the POU4F3 gene enhance the induction of cochlear hair cells.Analysis of hedgehog signaling in cerebellar granule cell precursors in a conditional Nsdhl allele demonstrates an essential role for cholesterol in postnatal CNS development.Functions of GSK-3 Signaling in Development of the Nervous System.N-myc is a key switch regulating the proliferation cycle of postnatal cerebellar granule cell progenitorsA Myc-Groucho complex integrates EGF and Notch signaling to regulate neural development.Glycogen synthase kinase 3β and activin/nodal inhibition in human embryonic stem cells induces a pre-neuroepithelial state that is required for specification to a floor plate cell lineage.Control of vertebrate development by MYCAn essential role for p38 MAPK in cerebellar granule neuron precursor proliferation.Expression profiling identifies novel Hh/Gli-regulated genes in developing zebrafish embryos.The insulin-like growth factor (IGF) receptor type 1 (IGF1R) as an essential component of the signalling network regulating neurogenesis.GSK-3 is a master regulator of neural progenitor homeostasis.Basal cell carcinoma and the carcinogenic role of aberrant Hedgehog signaling.Role of nitric oxide in cerebellar development and function: focus on granule neurons.Aberrant signaling pathways in medulloblastomas: a stem cell connection.MCPIP1 Exogenous Overexpression Inhibits Pathways Regulating MYCN Oncoprotein Stability in Neuroblastoma.Insulin receptor substrate 1 is an effector of sonic hedgehog mitogenic signaling in cerebellar neural precursors.Methylation of PTCH1, the Patched-1 gene, in a panel of primary medulloblastomas.Inhibition of IGF-I receptor in anchorage-independence attenuates GSK-3beta constitutive phosphorylation and compromises growth and survival of medulloblastoma cell lines.Kaposi's sarcoma-associated herpesvirus LANA protein downregulates nuclear glycogen synthase kinase 3 activity and consequently blocks differentiation.Isolation and culture of post-natal mouse cerebellar granule neuron progenitor cells and neuronsDual-activity PI3K-BRD4 inhibitor for the orthogonal inhibition of MYC to block tumor growth and metastasisGenomic analysis identifies new drivers and progression pathways in skin basal cell carcinoma.
P2860
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P2860
Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes.
description
2006 nî lūn-bûn
@nan
2006年の論文
@ja
2006年学术文章
@wuu
2006年学术文章
@zh-cn
2006年学术文章
@zh-hans
2006年学术文章
@zh-my
2006年学术文章
@zh-sg
2006年學術文章
@yue
2006年學術文章
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2006年學術文章
@zh-hant
name
Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes.
@ast
Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes.
@en
type
label
Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes.
@ast
Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes.
@en
prefLabel
Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes.
@ast
Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes.
@en
P356
P1433
P1476
Neural precursor cycling at sonic speed: N-Myc pedals, GSK-3 brakes.
@en
P2093
Anna Marie Kenney
Paul S Knoepfler
P356
10.4161/CC.5.1.2292
P577
2006-01-01T00:00:00Z