Progress toward the evolution of an organism with an expanded genetic code.
about
An expanded genetic code with a functional quadruplet codonSelective incorporation of 5-hydroxytryptophan into proteins in mammalian cellsAn archaebacteria-derived glutamyl-tRNA synthetase and tRNA pair for unnatural amino acid mutagenesis of proteins in Escherichia coliTwenty-first aminoacyl-tRNA synthetase-suppressor tRNA pairs for possible use in site-specific incorporation of amino acid analogues into proteins in eukaryotes and in eubacteriaSite-specific functionalization of proteins and their applications to therapeutic antibodiesProteins with beta-(thienopyrrolyl)alanines as alternative chromophores and pharmaceutically active amino acidsBioconjugation of therapeutic proteins and enzymes using the expanded set of genetically encoded amino acids.Fluorinated Coiled-Coil Proteins Prepared In Vivo Display Enhanced Thermal and Chemical Stability This work was supported by a grant from the U.S. Army Research Office. Y. Tang is supported by a Whitaker Graduate Research Fellowship. We thank Dr. GaInvestigating and Engineering Enzymes by Genetic Selection.Monitoring mis-acylated tRNA suppression efficiency in mammalian cells via EGFP fluorescence recovery.A mutant Escherichia coli tyrosyl-tRNA synthetase utilizes the unnatural amino acid azatyrosine more efficiently than tyrosine.Import of amber and ochre suppressor tRNAs into mammalian cells: a general approach to site-specific insertion of amino acid analogues into proteins.Selection and characterization of Escherichia coli variants capable of growth on an otherwise toxic tryptophan analogue.Reprogramming the genetic code.Performance analysis of orthogonal pairs designed for an expanded eukaryotic genetic code.Rational design of an orthogonal tryptophanyl nonsense suppressor tRNADiscovery of superior enzymes by directed molecular evolution.Noncanonical amino acids in the interrogation of cellular protein synthesisSite-specific incorporation of unnatural amino acids into proteins.Unnatural base pairs for specific transcription.Site Specific Genetic Incorporation of Azidophenylalanine in Schizosaccharomyces pombeEnhanced yield of recombinant proteins with site-specifically incorporated unnatural amino acids using a cell-free expression system.Atypical archaeal tRNA pyrrolysine transcript behaves towards EF-Tu as a typical elongator tRNA.The alpha,alpha-difluorinated phosphonate L-pSer-analogue: an accessible chemical tool for studying kinase-dependent signal transduction.What precision-protein-tuning and nano-resolved single molecule sciences can do for each other.Labeling of virus components for advanced, quantitative imaging analyses.Designing logical codon reassignment - Expanding the chemistry in biology.An in vivo selection system for homing endonuclease activity.Decoding of tandem quadruplets by adjacent tRNAs with eight-base anticodon loops.Discrimination of colon cancer stem cells using noncanonical amino acid.The fidelity of replication of the three-base-pair set adenine/thymine, hypoxanthine/cytosine and 6-thiopurine/5-methyl-2-pyrimidinone with T7 DNA polymerase.An expanded genetic code in Candida albicans to study protein-protein interactions in vivo.Making sense out of nonsense.Enlarging the amino acid set of Escherichia coli by infiltration of the valine coding pathway.Co-translational incorporation of trans-4-hydroxyproline into recombinant proteins in bacteria.Genetically encoding phosphotyrosine and its nonhydrolyzable analog in bacteria.Improving theranostics in pancreatic cancer.Free-energy simulations and experiments reveal long-range electrostatic interactions and substrate-assisted specificity in an aminoacyl-tRNA synthetase.A tRNA aminoacylation system for non-natural amino acids based on a programmable ribozymePosttranslational Modification of Proteins Incorporating Nonnatural Amino Acids
P2860
Q24562176-20991FCB-04C2-4F59-BF1F-4C6DCC4B91DAQ24562667-45F30D32-54EB-42E6-B0BF-1C5B7ED79C48Q24610610-97A29060-D276-4D3D-A7A8-9BE9DDFED853Q24617914-9732EB40-6591-4E4F-A7E4-6D0C9A62787EQ26830699-FFC02405-EC84-4835-9398-B55C2F2F3061Q28367374-77AFC93F-DD71-4BF1-A276-FC4787AF7F0DQ30279245-AF789342-BE2A-4406-A485-14CCAB10ED2FQ30665183-1E0896B9-9049-47D6-B3A4-A80685BC3DAEQ30731663-9743F907-1564-400A-8ECA-A07121673446Q31120351-3DB2DB4F-F6FB-4F26-A3B9-7544549D59ABQ33181124-1E00264D-0B44-4F32-B17A-9EFCDD82FEF8Q33951808-51CF7516-1EAF-420E-92D0-F23BF3AFD1EEQ33996847-7C19DCDB-A246-4689-87E6-9A29A37E6A9AQ34186603-CA879196-5F25-4762-ABD2-1FBF82455D03Q34228226-C340A5F4-2A22-4EA3-A193-C29DAA1F6318Q34246728-CBBA03EC-8EFE-4050-8557-2B00DC4F19A0Q34596533-BB5C6E8F-29CA-47E3-A274-8CBDF0C176AFQ35226309-70B8BC5A-FA99-46A6-AA93-B9986B62C0CFQ35828598-A619F7D7-8073-4586-B27F-F178D2FA1845Q35856552-8092341A-C4F6-468A-BFBD-E0BC9F620D94Q36310141-AA95FB26-AF1D-4E38-BD98-CB0C66147650Q36976537-39C05849-D55A-42DD-AAED-31BEEBFD27ADQ37071596-321F3A9C-15A8-45E8-8F89-AD7F8B943B7AQ37602835-E81166B5-7023-4B6F-89BD-BA2718C2EC60Q38059386-8CF94007-50B7-42B1-AC07-6A2F70B29781Q38778456-1F74C67D-0154-4B24-97EF-D1D1A5D85E06Q39065918-EBBB481C-514F-415D-9252-BE5FEB32A9C6Q39538487-7F0175A1-09D1-4D39-A802-61614E9DE7C3Q39584242-2419DB9D-EDB1-49D4-AA16-947DB229A2AEQ39885393-AF7FEE7E-D9AE-478A-A9E1-655006AB595EQ41852750-BAFFF995-F80D-45B6-A3B0-BE7F8906223EQ42107546-A72EC0AA-6908-4720-8D84-6BAD8379F3FAQ42441796-FAB585A4-D505-432C-808B-F87F203DFDC6Q43582952-1ED4D715-691A-49B5-9C81-D54CF42EF192Q44193821-0C8F2260-7AF2-44F1-A173-D2F59C1CCB5FQ46198324-4DF03DF8-6555-42C1-A11A-6A9820FC7591Q46466095-112C985C-C27A-40AB-BE5C-EF92E5DBF498Q46891251-B86AD2CB-0526-4C6D-9CC2-E44C3FB6E7BFQ56900783-4FF73E6A-0BBC-4756-8045-C94875F3162DQ58642514-E40977B8-6090-4415-8E61-1E9185A51CEE
P2860
Progress toward the evolution of an organism with an expanded genetic code.
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Progress toward the evolution of an organism with an expanded genetic code.
@ast
Progress toward the evolution of an organism with an expanded genetic code.
@en
type
label
Progress toward the evolution of an organism with an expanded genetic code.
@ast
Progress toward the evolution of an organism with an expanded genetic code.
@en
prefLabel
Progress toward the evolution of an organism with an expanded genetic code.
@ast
Progress toward the evolution of an organism with an expanded genetic code.
@en
P2860
P356
P1476
Progress toward the evolution of an organism with an expanded genetic code.
@en
P2093
P2860
P304
P356
10.1073/PNAS.96.9.4780
P407
P577
1999-04-01T00:00:00Z