Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes
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Stoichiometry of human recombinant neuronal nicotinic receptors containing the b3 subunit expressed in Xenopus oocytesNeuronal nicotinic receptors: from protein structure to functionAllosteric activation mechanism of the cys-loop receptorsA reporter mutation approach shows incorporation of the "orphan" subunit beta3 into a functional nicotinic receptorAn amino acid exchange in the second transmembrane segment of a neuronal nicotinic receptor causes partial epilepsy by altering its desensitization kineticsOpen probability of homomeric murine 5-HT3A serotonin receptors depends on subunit occupancyA unique amino acid of the Drosophila GABA receptor with influence on drug sensitivity by two mechanismsThe interaction of trichloroethanol with murine recombinant 5-HT3 receptorsSlow phases of GABA(A) receptor desensitization: structural determinants and possible relevance for synaptic functionLength and amino acid sequence of peptides substituted for the 5-HT3A receptor M3M4 loop may affect channel expression and desensitizationAllosteric activation mechanism of the alpha 1 beta 2 gamma 2 gamma-aminobutyric acid type A receptor revealed by mutation of the conserved M2 leucine.Minimal structural rearrangement of the cytoplasmic pore during activation of the 5-HT3A receptor.Functional evaluation of key interactions evident in the structure of the eukaryotic Cys-loop receptor GluCl.Desensitization of alpha7 nicotinic receptor is governed by coupling strength relative to gate tightnessMutation at the putative GABA(A) ion-channel gate reveals changes in allosteric modulation.Neuronal nicotinic threonine-for-leucine 247 alpha7 mutant receptors show different gating kinetics when activated by acetylcholine or by the noncompetitive agonist 5-hydroxytryptamine.Domains of P2X receptors involved in desensitizationAn engineered glutamate-gated chloride (GluCl) channel for sensitive, consistent neuronal silencing by ivermectin.A single channel mutation alters agonist efficacy at 5-HT3A and 5-HT3AB receptors.The multiple phenotypes of allosteric receptor mutants.Crystal structure and dynamics of a lipid-induced potential desensitized-state of a pentameric ligand-gated channel.The structural mechanism of the Cys-loop receptor desensitization.On the voltage-dependent Ca2+ block of serotonin 5-HT3 receptors: a critical role of intracellular phosphates.Co-expression of the 5-HT3B serotonin receptor subunit alters the biophysics of the 5-HT3 receptor.Arginine 222 in the pre-transmembrane domain 1 of 5-HT3A receptors links agonist binding to channel gating.A single ring of charged amino acids at one end of the pore can control ion selectivity in the 5-HT3 receptorConversion of the ion selectivity of the 5-HT(3a) receptor from cationic to anionic reveals a conserved feature of the ligand-gated ion channel superfamily.The 4'lysine in the putative channel lining domain affects desensitization but not the single-channel conductance of recombinant homomeric 5-HT3A receptors.An electrophysiological investigation of the properties of a murine recombinant 5-HT3 receptor stably expressed in HEK 293 cellsStoichiometry of δ subunit containing GABA(A) receptors.Modulation by calcineurin of 5-HT3 receptor function in NG108-15 neuroblastoma x glioma cells.Selection of distinct conformational states of the 5-HT3 receptor by full and partial agonists.Desensitization mechanism in prokaryotic ligand-gated ion channelConformational transitions underlying pore opening and desensitization in membrane-embedded Gloeobacter violaceus ligand-gated ion channel (GLIC)Structural and electrostatic properties of the 5-HT3 receptor pore revealed by substituted cysteine accessibility mutagenesis.Desensitization and resensitization of human platelets to 5-hydroxytryptamine at the level of signal transduction.Neuroepithelial bodies in mammalian lung express functional serotonin type 3 receptor.Approaching the 5-HT₃ receptor heterogeneity by computational studies of the transmembrane and intracellular domains.Expression and function of 5-HT3 receptors in the enteric neurons of mice lacking the serotonin transporter.Chimeric mutations in the M2 segment of the 5-hydroxytryptamine-gated chloride channel MOD-1 define a minimal determinant of anion/cation permeability.
P2860
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P2860
Single amino acid substitution affects desensitization of the 5-hydroxytryptamine type 3 receptor expressed in Xenopus oocytes
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
1993年學術文章
@zh
1993年學術文章
@zh-hant
name
Single amino acid substitution ...... r expressed in Xenopus oocytes
@ast
Single amino acid substitution ...... r expressed in Xenopus oocytes
@en
type
label
Single amino acid substitution ...... r expressed in Xenopus oocytes
@ast
Single amino acid substitution ...... r expressed in Xenopus oocytes
@en
prefLabel
Single amino acid substitution ...... r expressed in Xenopus oocytes
@ast
Single amino acid substitution ...... r expressed in Xenopus oocytes
@en
P2093
P2860
P356
P1476
Single amino acid substitution ...... r expressed in Xenopus oocytes
@en
P2093
A Lagrutta
J P Adelman
P2860
P304
P356
10.1073/PNAS.90.11.5030
P407
P577
1993-06-01T00:00:00Z