Arginine 222 in the pre-transmembrane domain 1 of 5-HT3A receptors links agonist binding to channel gating.
about
Recessive hyperekplexia mutations of the glycine receptor alpha1 subunit affect cell surface integration and stabilityPore conformations and gating mechanism of a Cys-loop receptor.Subunit symmetry at the extracellular domain-transmembrane domain interface in acetylcholine receptor channel gating.The 5-HT3B subunit confers spontaneous channel opening and altered ligand properties of the 5-HT3 receptor.Pregnancy upregulates large-conductance Ca(2+)-activated K(+) channel activity and attenuates myogenic tone in uterine arteries.Cannabinoid potentiation of glycine receptors contributes to cannabis-induced analgesia.The L293 residue in transmembrane domain 2 of the 5-HT3A receptor is a molecular determinant of allosteric modulation by 5-hydroxyindole.Number and locations of agonist binding sites required to activate homomeric Cys-loop receptorsThe structural basis of function in Cys-loop receptors.Synaptic neurotransmitter-gated receptorsAdditional acetylcholine (ACh) binding site at alpha4/alpha4 interface of (alpha4beta2)2alpha4 nicotinic receptor influences agonist sensitivity.Modulation of 5-HT3 receptor desensitization by the light chain of microtubule-associated protein 1B expressed in HEK 293 cells.The pre-M1 segment of the alpha1 subunit is a transduction element in the activation of the GABAA receptor.Ligand binding transmits conformational changes across the membrane-spanning region to the intracellular side of the 5-HT3 serotonin receptor.Role of aspartate 298 in mouse 5-HT3A receptor gating and modulation by extracellular Ca2+.Trapping of ivermectin by a pentameric ligand-gated ion channel upon open-to-closed isomerization.Structural basis for allosteric coupling at the membrane-protein interface in Gloeobacter violaceus ligand-gated ion channel (GLIC).Acetylcholine receptor gating at extracellular transmembrane domain interface: the "pre-M1" linker.Mutational Analysis at Intersubunit Interfaces of an Anionic Glutamate Receptor Reveals a Key Interaction Important for Channel Gating by Ivermectin.Charged residues in the beta2 subunit involved in GABAA receptor activation.A novel hyperekplexia-causing mutation in the pre-transmembrane segment 1 of the human glycine receptor alpha1 subunit reduces membrane expression and impairs gating by agonists.Study, by use of coarse-grained models, of the functionally crucial residues and allosteric pathway of anesthetic regulation of the Gloeobacter violaceus ligand-gated ion channel.Dipicrylamine Modulates GABAρ1 Receptors through Interactions with Residues in the TM4 and Cys-Loop Domains.Principal pathway coupling agonist binding to channel gating in nicotinic receptors.
P2860
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P2860
Arginine 222 in the pre-transmembrane domain 1 of 5-HT3A receptors links agonist binding to channel gating.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年論文
@yue
2003年論文
@zh-hant
2003年論文
@zh-hk
2003年論文
@zh-mo
2003年論文
@zh-tw
2003年论文
@wuu
2003年论文
@zh
2003年论文
@zh-cn
name
Arginine 222 in the pre-transm ...... ist binding to channel gating.
@en
type
label
Arginine 222 in the pre-transm ...... ist binding to channel gating.
@en
prefLabel
Arginine 222 in the pre-transm ...... ist binding to channel gating.
@en
P2093
P2860
P356
P1476
Arginine 222 in the pre-transm ...... ist binding to channel gating.
@en
P2093
Forrest F Weight
Randall R Stewart
Xiang-Qun Hu
P2860
P304
46583-46589
P356
10.1074/JBC.M308974200
P407
P577
2003-09-11T00:00:00Z