HLA class II regulation and structure. Analysis with HLA-DR3 and HLA-DP point mutants
about
Point mutations define positions in HLA-DR3 molecules that affect antigen presentation.Complexes of two cohorts of CLIP peptides and HLA-DQ2 of the autoimmune DR3-DQ2 haplotype are poor substrates for HLA-DMThe MHC class II cofactor HLA-DM interacts with Ig in B cells.In the absence of the invariant chain, HLA-DR molecules display a distinct array of peptides which is influenced by the presence or absence of HLA-DMA gene required for class II-restricted antigen presentation maps to the major histocompatibility complexA single amino acid substitution in the human histocompatibility leukocyte antigen DR3 beta chain selectively alters antigen presentation.A mutant human histocompatibility leukocyte antigen DR molecule associated with invariant chain peptides.Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85-99 complex.Novel mutants define genes required for the expression of human histocompatibility leukocyte antigen DM: evidence for loci on human chromosome 6pImmunomodulatory properties of a viral homolog of human interleukin-10 expressed by human cytomegalovirus during the latent phase of infection.Transcription of HLA class II genes in the absence of B-cell-specific octamer-binding factor.Expression of HLA-DR antigen in human class II mutant B-cell lines by double infection with retrovirus vectors.Class II-antigen-negative patient and mutant B-cell lines represent at least three, and probably four, distinct genetic defects defined by complementation analysisToward a Network Model of MHC Class II-Restricted Antigen Processing.DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms.Masking of a cathepsin G cleavage site in vivo contributes to the proteolytic resistance of major histocompatibility complex class II molecules.Factors governing the binding and recognition of foreign and self-peptides by MHC class II.HLA-DR beta chains enter into an aggregated complex containing GRP-78/BiP prior to their degradation by the pre-Golgi degradative pathway.Two distinct genetic loci regulating class II gene expression are defective in human mutant and patient cell lines.Modulation of the major histocompatibility complex class II-associated peptide repertoire by human histocompatibility leukocyte antigen (HLA)-DO.
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P2860
HLA class II regulation and structure. Analysis with HLA-DR3 and HLA-DP point mutants
description
1985 nî lūn-bûn
@nan
1985年の論文
@ja
1985年学术文章
@wuu
1985年学术文章
@zh-cn
1985年学术文章
@zh-hans
1985年学术文章
@zh-my
1985年学术文章
@zh-sg
1985年學術文章
@yue
1985年學術文章
@zh
1985年學術文章
@zh-hant
name
HLA class II regulation and structure. Analysis with HLA-DR3 and HLA-DP point mutants
@ast
HLA class II regulation and structure. Analysis with HLA-DR3 and HLA-DP point mutants
@en
type
label
HLA class II regulation and structure. Analysis with HLA-DR3 and HLA-DP point mutants
@ast
HLA class II regulation and structure. Analysis with HLA-DR3 and HLA-DP point mutants
@en
prefLabel
HLA class II regulation and structure. Analysis with HLA-DR3 and HLA-DP point mutants
@ast
HLA class II regulation and structure. Analysis with HLA-DR3 and HLA-DP point mutants
@en
P2093
P2860
P356
P1476
HLA class II regulation and structure. Analysis with HLA-DR3 and HLA-DP point mutants
@en
P2093
P2860
P304
P356
10.1084/JEM.162.4.1193
P407
P577
1985-10-01T00:00:00Z