Single germline VH and V kappa genes encode predominating antibody variable regions elicited in strain A mice by immunization with p-azophenylarsonate.
about
Structural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-foldIsotype switching by a microinjected mu immunoglobulin heavy chain gene in transgenic miceSilent development of memory progenitor B cellsThe human antibody V region repertoire to the type B capsular polysaccharide of Haemophilus influenzae.Selection of immunoglobulin variable regions in autoimmunity to DNA.Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response.Both IgM and IgG anti-DNA antibodies are the products of clonally selective B cell stimulation in (NZB x NZW)F1 mice.Parallel evolution of antibody variable regions by somatic processes: consecutive shared somatic alterations in VH genes expressed by independently generated hybridomas apparently acquired by point mutation and selection rather than by gene conversiEvolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte.Molecular analysis of original antigenic sin. I. Clonal selection, somatic mutation, and isotype switching during a memory B cell responseSomatically mutated forms of a major anti-p-azophenylarsonate antibody variable region with drastically reduced affinity for p-azophenylarsonate. By-products of an antigen-driven immune response?Tracing the development of single memory-lineage B cells in a highly defined immune response.Sequencing heavy- and light-chain variable genes of single B-hybridoma cells by total enzymatic amplificationCrystal structure of the antigen-binding fragment of the murine anti-arsonate monoclonal antibody 36-71 at 2.9-A resolution.Pathogenic anti-DNA antibodies in SLE: idiotypic families and genetic origins.Anti-DNA antibodies, autoimmunity and the immunoglobulin repertoire.Oligonucleotide-directed mutagenesis of antibody combining sites.Restricted, canonical, stereotyped and convergent immunoglobulin responses.Genetic control of early antibody responses.Monitoring the acute phase response: comparison of tumour necrosis factor (cachectin) and C-reactive protein responses in inflammatory and infectious diseases.'Allelic' forms of immunoglobulin V genes in different strains of miceCharacteristics of the immunoglobulin Vkappa genes, pseudogenes, relics and orphons in the mouse genome.
P2860
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P2860
Single germline VH and V kappa genes encode predominating antibody variable regions elicited in strain A mice by immunization with p-azophenylarsonate.
description
1987 nî lūn-bûn
@nan
1987年の論文
@ja
1987年学术文章
@wuu
1987年学术文章
@zh-cn
1987年学术文章
@zh-hans
1987年学术文章
@zh-my
1987年学术文章
@zh-sg
1987年學術文章
@yue
1987年學術文章
@zh
1987年學術文章
@zh-hant
name
Single germline VH and V kappa ...... tion with p-azophenylarsonate.
@ast
Single germline VH and V kappa ...... tion with p-azophenylarsonate.
@en
type
label
Single germline VH and V kappa ...... tion with p-azophenylarsonate.
@ast
Single germline VH and V kappa ...... tion with p-azophenylarsonate.
@en
prefLabel
Single germline VH and V kappa ...... tion with p-azophenylarsonate.
@ast
Single germline VH and V kappa ...... tion with p-azophenylarsonate.
@en
P2093
P2860
P356
P1476
Single germline VH and V kappa ...... tion with p-azophenylarsonate.
@en
P2093
P2860
P356
10.1084/JEM.166.1.1
P407
P577
1987-07-01T00:00:00Z