Somatic evolution of variable region structures during an immune response. - Wikidata - awgldk - TriplyDB

Somatic evolution of variable region structures during an immune response.

Somatic evolution of variable region structures during an immune response.

http://www.wikidata.org/entity/Q35595595

about

The structural basis of repertoire shift in an immune response to phosphocholine Cytologic assessment of nuclear and cytoplasmic O-linked N-acetylglucosamine distribution by using anti-streptococcal monoclonal antibodies Immunoglobulin heavy chain gene expression in peripheral blood B lymphocytes.Identification of mutant monoclonal antibodies with increased antigen binding Molecular cloning of the primary IgH repertoire: a quantitative analysis of VH gene usage in adult mice Structural correlates of high antibody affinity: three engineered amino acid substitutions can increase the affinity of an anti-p-azophenylarsonate antibody 200-fold Protein evolution on partially correlated landscapes.Silent development of memory progenitor B cells Somatic hypermutation as a generator of antinuclear antibodies in a murine model of systemic autoimmunity.Analysis of autoantibodies to recombinant La (SS-B) peptides in systemic lupus erythematosus and primary Sjogren's syndrome.Protein evolution on rugged landscapes.Kinetic and affinity limits on antibodies produced during immune responses.Retention of an idiotypic determinant in a human B-cell lymphoma undergoing immunoglobulin variable-region mutation Self-tolerance checkpoints in CD4 T cells specific for a peptide derived from the B cell antigen receptor.Aborted germinal center reactions and B cell memory by follicular T cells specific for a B cell receptor V region peptide.Different epitope structures select distinct mutant forms of an antibody variable region for expression during the immune response.A model for the evolution of the mammalian t-cell receptor α/δ and μ loci based on evidence from the duckbill Platypus.Clonal analysis of a human antibody response. II. Sequences of the VH genes of human IgM, IgG, and IgA to rabies virus reveal preferential utilization of VHIII segments and somatic hypermutation Anti-DNA antibodies from autoimmune mice arise by clonal expansion and somatic mutation.Spontaneous loss and alteration of antigen receptor expression in mature CD4+ T cells.Parallel evolution of antibody variable regions by somatic processes: consecutive shared somatic alterations in VH genes expressed by independently generated hybridomas apparently acquired by point mutation and selection rather than by gene conversi A single germline VH gene segment of normal A/J mice encodes autoantibodies characteristic of systemic lupus erythematosus Idiotype variant cell populations in patients with B cell lymphoma.Single germline VH and V kappa genes encode predominating antibody variable regions elicited in strain A mice by immunization with p-azophenylarsonate.Influence of the macromolecular form of a B cell epitope on the expression of antibody variable and constant region structure.Boundaries of somatic mutation in rearranged immunoglobulin genes: 5' boundary is near the promoter, and 3' boundary is approximately 1 kb from V(D)J gene.Mutational hot spots in Ig V region genes of human follicular lymphomas T cell receptor gene usage in the response to lambda repressor cI protein. An apparent bias in the usage of a V alpha gene element Macrophages phagocytose thymic lymphocytes with productively rearranged T cell receptor alpha and beta genes.Relationship of variable region genes expressed by a human B cell lymphoma secreting pathologic anti-Pr2 erythrocyte autoantibodies.Early onset of somatic mutation in immunoglobulin VH genes during the primary immune response Evolution of antibody structure during the immune response. The differentiative potential of a single B lymphocyte.Molecular analysis of original antigenic sin. I. Clonal selection, somatic mutation, and isotype switching during a memory B cell response Somatically mutated forms of a major anti-p-azophenylarsonate antibody variable region with drastically reduced affinity for p-azophenylarsonate. By-products of an antigen-driven immune response?Protective and nonprotective monoclonal antibodies to Cryptococcus neoformans originating from one B cell Tracing the development of single memory-lineage B cells in a highly defined immune response.Very low affinity B cells form germinal centers, become memory B cells, and participate in secondary immune responses when higher affinity competition is reduced Antigen-driven clonal proliferation of B cells within the target tissue of an autoimmune disease. The salivary glands of patients with Sjögren's syndrome Crystal structure of the antigen-binding fragment of the murine anti-arsonate monoclonal antibody 36-71 at 2.9-A resolution.The biologic significance of human natural autoimmune responses: relationship to the germline, early immune and malignant B cell variable gene repertoire.

P2860

Q27624954-8E5F0FD4-17CE-48FA-B6B0-6E74FEC2B0B1 Q28329475-20043F72-0067-4C99-8468-FEC5CAAA31D3 Q31131763-CE8425F9-31A7-4EC3-BE7E-2542F29B8707 Q33564356-DAF0E628-1F97-4B6A-9DE1-DD75EE4D8569 Q33572492-40732130-2557-4D8E-AE57-E2159B78DC05 Q33646218-58EB04C0-4ADD-48BB-A70C-76BD4F811B2B Q33860729-4667DBC3-B00C-4A04-A694-FCAA5253E500 Q33959225-AE7FB197-0FC3-4527-A1F9-28B40A3027B9 Q34161517-70D5D13B-CDC8-4B4A-8A75-4120994D3F6E Q34241668-2E143F6B-DEBE-4DB7-BD2A-C3482078C9AD Q34296709-D70995EC-CB73-4F65-A64D-1A70C5F7A97B Q34598643-0EFB8DF8-D24D-435F-8E0C-A74F8F3D1737 Q34641348-0B6DF138-288D-4CD2-AA69-5049FDBF6E22 Q35071223-A8552321-E584-4D65-B525-BB3642F66422 Q35097270-FE799CA1-22C8-4484-9C2D-7CA17185A1B0 Q36229997-4B0E8984-955D-4779-95C5-4755528A75E0 Q36278222-21836FE9-C07B-464B-8C82-0F7D6986B02E Q36341119-016AB9D1-D1AB-4E52-BBBF-D22B1E912ACA Q36350233-F85021A4-8910-48C8-9D67-42CF72868DB2 Q36351344-90845299-D080-4DA2-83D7-08BB71EE623E Q36352059-99A5FA70-47B6-4C77-B0EE-7611818FC684 Q36352279-017FCDF6-075E-4991-911F-66AFEBA6023E Q36353115-6AB8EBD8-2DF4-4824-A0BB-C8882393F41C Q36353768-23EDC060-B2BE-4760-8802-28BBA1073EB1 Q36353883-89332A55-ED93-4658-B9FB-9F78EE4C3CCB Q36354162-FC91B99A-62F3-4C31-B6C5-21F5C5F913CF Q36355166-0E1DE005-3F3D-49AF-9A67-051B0E76EE0F Q36355341-4A9CA532-2187-46A5-9799-7352E53AAFA7 Q36355765-660F22FF-B382-41E2-A34C-7D3FF1914655 Q36356325-AC46E84F-5B39-453A-95A4-35074A9CEB35 Q36356525-0923A911-8851-467A-8B94-A04E05B82BE2 Q36356890-C3681EE3-3CE2-4C1E-8C2E-7325C3A70CA7 Q36356910-542A306A-E5E8-4423-BE5D-E9404EBF8514 Q36357474-2294D2CC-1D4A-46C4-97F2-8130D1E8C5DE Q36364342-49EF6E44-C094-4D63-A89B-78B4A23CFF76 Q36366754-97E68022-6762-4A88-BB58-D66AAF6BC16A Q36370154-7A0B3CB5-2319-4D11-A73D-A284959D739C Q37384819-83C8F72C-EA14-402F-B2F3-FB1DEF90ED59 Q37666230-5A002F6F-9A23-47D1-AC54-3294C86D687B Q37837361-213B2C75-AE5A-4661-BC4C-78B171803F4D

P2860

Somatic evolution of variable region structures during an immune response.

http://www.wikidata.org/entity/Q35595595

description

1986 nî lūn-bûn

@nan

1986年の論文

@ja

1986年論文

@yue

1986年論文

@zh-hant

1986年論文

@zh-hk

1986年論文

@zh-mo

1986年論文

@zh-tw

1986年论文

@wuu

1986年论文

@zh

1986年论文

@zh-cn

name

Somatic evolution of variable region structures during an immune response.

@ast

Somatic evolution of variable region structures during an immune response.

@en

type

label

Somatic evolution of variable region structures during an immune response.

@ast

Somatic evolution of variable region structures during an immune response.

@en

prefLabel

Somatic evolution of variable region structures during an immune response.

@ast

Somatic evolution of variable region structures during an immune response.

@en

P1433

Q35595595-C26582D7-1346-466D-98B6-BCD94E8DC13D

P1476

Q35595595-5CD46E45-F769-4E1E-8ADA-DD09F6657A5E

P2093

Q35595595-3D3AF59C-77D8-42C2-9F80-7EF025A6CA84

Q35595595-75C180BA-B608-40C8-B7CF-618F548389E4

Q35595595-AC5B94E0-DEC5-4AF8-984A-8C5CEDB1DAC8

P2860

Q35595595-003D13C8-3E5B-4D80-81A0-3A6E0BFFC742

Q35595595-0608407B-5F09-4593-A4ED-7FF88D8067CD

Q35595595-0DA88806-9A00-401C-8A3B-C9867E802E6C

Q35595595-2BB7CB9D-C0B2-4679-847F-ED26B41D84DC

Q35595595-2F74CFEC-522A-4957-A514-10850A4F8CCE

Q35595595-428C11AB-3299-4F36-832E-43684EE771BA

Q35595595-4B944C33-884B-4152-9BD2-C66A1C9CE69B

Q35595595-505D69DA-D4CC-4F3D-945D-6F6A5F556832

Q35595595-52CA866C-219C-4EAE-8523-09840407EBA8

Q35595595-5D0E3CEA-BBB3-4E26-8239-0DBCB6BF0F15

P304

Q35595595-4AD8D700-C6AE-49E9-AA70-FE57A0AFFD9E

P31

Q35595595-3292B965-DED8-4FF5-8E64-36412B489BE8

P356

Q35595595-F13A12A0-2356-471E-A0A1-E3EB85FFF7A9

P407

Q35595595-76A3155B-969B-4050-91B2-09F0199687F4

P433

Q35595595-8A885A9F-8E7D-4ED1-82C9-7ED4398D16A1

P478

Q35595595-E335D10F-430C-488E-AE7F-E96D90B14E19

P577

Q35595595-7AF52511-36EF-47F5-8B9D-D975FC38096D

P5875

Q35595595-F49ECC95-8798-4FFE-A920-B7DFD49F8900

P698

Q35595595-299CF6ED-92D9-404A-88F5-D53EAF81B173

P932

Q35595595-76C21A02-0DE9-4CDF-AA05-AA345C2CE7D1

P356

P1433

Proceedings of the National Academy of Sciences of the United States of America

P1476

Somatic evolution of variable region structures during an immune response.

@en

P2093

L Wysocki

http://www.w3.org/2001/XMLSchema#string

M L Gefter

http://www.w3.org/2001/XMLSchema#string

T Manser

http://www.w3.org/2001/XMLSchema#string

P2860

Continuous cultures of fused cells secreting antibody of predefined specificity

Cell separation on affinity columns: the isolation of immunospecific precursor cells from unimmunized mice (lactoside hapten-lymphocyte receptors-immunology).

Isolation of hybridomas expressing a specific heavy chain variable region gene segment by using a screening technique that detects mRNA sequences in whole cell lysates

Generation of antibody diversity in the immune response of BALB/c mice to influenza virus hemagglutinin.

Quantitative investigations of idiotypic antibodies. VI. Idiotypic specificity as a potential genetic marker for the variable regions of mouse immunoglobulin polypeptide chains.

Isolation of antigen-binding cells from unprimed mice: demonstration of antibody-forming cell precursor activity and correlation between precursor and secreted antibody avidities.

Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions

Amino acid sequence diversity within the family of antibodies bearing the major antiarsonate cross-reactive idiotype of the A strain mouse.

Hybridoma proteins expressing the predominant idiotype of the antiazophenylarsonate response of A/J mice.

Complete amino acid sequence of light chain variable regions derived from five monoclonal anti-p-azophenylarsonate antibodies differing with respect to a crossreactive idiotype

P304

1847-1851

http://www.w3.org/2001/XMLSchema#string

P31

scholarly article

P356

10.1073/PNAS.83.6.1847

http://www.w3.org/2001/XMLSchema#string

P407

P433

6

http://www.w3.org/2001/XMLSchema#string

P478

83

http://www.w3.org/2001/XMLSchema#string

P577

1986-03-01T00:00:00Z

http://www.w3.org/2001/XMLSchema#dateTime

P5875

19671632

http://www.w3.org/2001/XMLSchema#string

P698

3485290

http://www.w3.org/2001/XMLSchema#string

P932

323181

http://www.w3.org/2001/XMLSchema#string