Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis - Wikidata - awgldk - TriplyDB

Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis

Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis

http://www.wikidata.org/entity/Q36366280

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Arginase as a Critical Prooxidant Mediator in the Binomial Endothelial Dysfunction-Atherosclerosis Reactive oxygen species in inflammation and tissue injury Long term exposure to L-arginine accelerates endothelial cell senescence through arginase-II and S6K1 signaling Human papillomavirus e7 oncoprotein transgenic skin develops an enhanced inflammatory response to 2,4-dinitrochlorobenzene by an arginase-1-dependent mechanism.Functions of arginase isoforms in macrophage inflammatory responses: impact on cardiovascular diseases and metabolic disorders.Label-free quantitative urinary proteomics identifies the arginase pathway as a new player in congenital obstructive nephropathy.Arginase inhibition augments nitric oxide production and facilitates left ventricular systolic function in doxorubicin-induced cardiomyopathy in mice.Increased endothelial inflammation, sTie-2 and arginase activity in umbilical cords obtained from gestational diabetic mothers Role of p38 mitogen-activated protein kinase in vascular endothelial aging: interaction with Arginase-II and S6K1 signaling pathway p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-uncoupling in obesity ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis.Arginase inhibition attenuates arteriogenesis and interferes with M2 macrophage accumulation.Arginase-I enhances vascular endothelial inflammation and senescence through eNOS-uncoupling.Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation.Mincle-mediated translational regulation is required for strong nitric oxide production and inflammation resolution.Role of arginase in vessel wall remodeling.Arginase promotes skeletal muscle arteriolar endothelial dysfunction in diabetic rats Arginase: the emerging therapeutic target for vascular oxidative stress and inflammation.Arginase inhibition mediates renal tissue protection in diabetic nephropathy by a nitric oxide synthase 3-dependent mechanism Arginase-II induces vascular smooth muscle cell senescence and apoptosis through p66Shc and p53 independently of its l-arginine ureahydrolase activity: implications for atherosclerotic plaque vulnerability Genetic Targeting of Arginase-II in Mouse Prevents Renal Oxidative Stress and Inflammation in Diet-Induced Obesity.Molecular biology of atherosclerosis.Molecular pathways of arterial aging.PKCη deficiency improves lipid metabolism and atherosclerosis in apolipoprotein E-deficient mice.Arginase-II Deficiency Extends Lifespan in Mice.Microbiota of Chronic Diabetic Wounds: Ecology, Impact, and Potential for Innovative Treatment Strategies.Polarization of Macrophages toward M2 Phenotype Is Favored by Reduction in iPLA2β (Group VIA Phospholipase A2)Arginase II: atherogenesis beyond enzyme activity.Increased levels of circulating arginase I in overweight compared to normal weight adolescents.Arginase II inhibition prevents interleukin-8 production through regulation of p38 MAPK phosphorylation activated by loss of mitochondrial membrane potential in nLDL-stimulated hAoSMCs.Long-term dietary restriction up-regulates activity and expression of renal arginase II in aging mice.Deficient Arginase II Expression without Alteration in Arginase I Expression Attenuated Experimental Autoimmune Encephalomyelitis in Mice.Kidney Mass Reduction Leads to l-Arginine Metabolism-Dependent Blood Pressure Increase in Mice.Arginase inhibition prevents the development of hypertension and improves insulin resistance in obese rats.Asymmetric dimethylarginine (ADMA) elevation and arginase up-regulation contribute to endothelial dysfunction related to insulin resistance in rats and morbidly obese humans.Elevated levels of plasma symmetric dimethylarginine and increased arginase activity as potential indicators of cardiovascular comorbidity in rheumatoid arthritis.

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Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species, Contributing to Insulin Resistance and Atherogenesis

http://www.wikidata.org/entity/Q36366280

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Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease

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Angana G Rajapakse

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Brenda R Kwak

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Claudio Sartori

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Isabelle Scerri

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Jean Ruffieux

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Jean-Pierre Montani

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Jianhui Li

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Urs Scherrer

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Xiu-Fen Ming

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P2860

Inflammation and lung cancer: roles of reactive oxygen/nitrogen species

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Exploring the full spectrum of macrophage activation

Atherosclerosis — An Inflammatory Disease

A role for mitochondria in NLRP3 inflammasome activation

Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells

Autophagy proteins regulate innate immune responses by inhibiting the release of mitochondrial DNA mediated by the NALP3 inflammasome

Monocyte and macrophage heterogeneity

The chemokine system in diverse forms of macrophage activation and polarization

Macrophages, inflammation, and insulin resistance

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