Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals - Wikidata - awgldk - TriplyDB

Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

http://www.wikidata.org/entity/Q36368282

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Mammalian Ku86 mediates chromosomal fusions and apoptosis caused by critically short telomeres.Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation Repair of cyclobutane pyrimidine dimers or dimethylsulfate damage in DNA is identical in normal or telomerase-immortalized human skin fibroblasts.Role of Telomerase in the Cardiovascular System Aging and radiation: bad companions Recruitment of Rad51 and Rad52 to short telomeres triggers a Mec1-mediated hypersensitivity to double-stranded DNA breaks in senescent budding yeast Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient mice Telomerase reverse transcriptase promotes cardiac muscle cell proliferation, hypertrophy, and survival Natural and pharmacological regulation of telomerase A non-canonical function of zebrafish telomerase reverse transcriptase is required for developmental hematopoiesis.Ionizing radiation and aging: rejuvenating an old idea.The telomerase reverse transcriptase regulates chromatin state and DNA damage responses.An increase in telomere sister chromatid exchange in murine embryonic stem cells possessing critically shortened telomeres.Mice with bad ends: mouse models for the study of telomeres and telomerase in cancer and aging.Study of the expressions of p53 and bcl-2 genes, the telomerase activity and apoptosis in GIST patients.Functional interaction between DNA-PKcs and telomerase in telomere length maintenance.Reactive oxygen species in normal and tumor stem cells.Telomere profiling: toward glioblastoma personalized medicine.Telomere length in Chernobyl accident recovery workers in the late period after the disaster Many ways to telomere dysfunction: in vivo studies using mouse models.Phosphorylation of H2AX at short telomeres in T cells and fibroblasts.Short telomeres induce a DNA damage response in Saccharomyces cerevisiae.Molecular parameters of hyperthermia for radiosensitization.Phenotypes in mTERT⁺/⁻ and mTERT⁻/⁻ mice are due to short telomeres, not telomere-independent functions of telomerase reverse transcriptase Telomere shortening alters the kinetics of the DNA damage response after ionizing radiation in human cells.Telomere length assessment in human archival tissues: combined telomere fluorescence in situ hybridization and immunostaining DNA damage checkpoint kinase Chk2 triggers replicative senescence.Telomeres, telomerase, and apoptosis.Targeted deletion reveals an essential function for the telomere length regulator Trf1.Reactive oxygen species and hematopoietic stem cell senescence.Telomeres and Telomerase in the Radiation Response: Implications for Instability, Reprograming, and Carcinogenesis.Impact of telomerase ablation on organismal viability, aging, and tumorigenesis in mice lacking the DNA repair proteins PARP-1, Ku86, or DNA-PKcs Normal telomere length and chromosomal end capping in poly(ADP-ribose) polymerase-deficient mice and primary cells despite increased chromosomal instability.Heregulin, a new regulator of telomere length in human cells Is telomere length in peripheral blood lymphocytes correlated with cancer susceptibility or radiosensitivity?Novel connections between DNA replication, telomere homeostasis, and the DNA damage response revealed by a genome-wide screen for TEL1/ATM interactions in Saccharomyces cerevisiae.Cancer therapy-induced residual bone marrow injury-Mechanisms of induction and implication for therapy.Hematopoietic stem cell injury induced by ionizing radiation.Constitutive expression of tert in thymocytes leads to increased incidence and dissemination of T-cell lymphoma in Lck-Tert mice.Dynamics of telomeric chromatin at the crossroads of aging and cancer.

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P2860

Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

http://www.wikidata.org/entity/Q36368282

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2000 nî lūn-bûn

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2000年の論文

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2000年学术文章

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2000年学术文章

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2000年學術文章

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2000年學術文章

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2000年學術文章

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name

Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

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Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

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Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

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Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

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prefLabel

Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

@ast

Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

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Journal of Experimental Medicine

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Short telomeres result in organismal hypersensitivity to ionizing radiation in mammals

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E Samper

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F A Goytisolo

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P2860

Ku binds telomeric DNA in vitro

Ku is associated with the telomere in mammals

Cell-cycle-regulated association of RAD50/MRE11/NBS1 with TRF2 and human telomeres

Relocalization of telomeric Ku and SIR proteins in response to DNA strand breaks in yeast.

MEC1-dependent redistribution of the Sir3 silencing protein from telomeres to DNA double-strand breaks

Telomere dysfunction impairs DNA repair and enhances sensitivity to ionizing radiation

Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination

The mechanism of V(D)J joining: lessons from molecular, immunological, and comparative analyses

Targeted disruption of the catalytic subunit of the DNA-PK gene in mice confers severe combined immunodeficiency and radiosensitivity

Telomere shortening and tumor formation by mouse cells lacking telomerase RNA

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