CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes.
about
Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunityAbsence of marginal zone B cells in Pyk-2-deficient mice defines their role in the humoral responseA novel subset of memory B cells is enriched in autoreactivity and correlates with adverse outcomes in SLEB cell activating factor (BAFF) and T cells cooperate to breach B cell tolerance in lupus-prone New Zealand Black (NZB) miceThe role of complement in the acquired immune response.B cells and type 1 diabetes ...in mice and men.The viral latency-associated nuclear antigen augments the B-cell response to antigen in vivoCD19-dependent B lymphocyte signaling thresholds influence skin fibrosis and autoimmunity in the tight-skin mouseLin28b promotes fetal B lymphopoiesis through the transcription factor Arid3aB-cell homeostasis, competition, resources, and positive selection by self-antigens.Alternative routes to maturity: branch points and pathways for generating follicular and marginal zone B cells.Manipulation of the glycan-specific natural antibody repertoire for immunotherapyMacrophages prevent the differentiation of autoreactive B cells by secreting CD40 ligand and interleukin-6Loss of the proapoptotic protein, Bim, breaks B cell anergyReceptor cross-talk spatially restricts p-ERK during TLR4 stimulation of autoreactive B cells.Deficiency in CD22, a B cell-specific inhibitory receptor, is sufficient to predispose to development of high affinity autoantibodies.CD5 maintains tolerance in anergic B cellsDifferential regulation of B cell development, activation, and death by the src homology 2 domain-containing 5' inositol phosphatase (SHIP)Targeting of Ly9 (CD229) Disrupts Marginal Zone and B1 B Cell Homeostasis and Antibody ResponsesCD19 regulates skin and lung fibrosis via Toll-like receptor signaling in a model of bleomycin-induced scleroderma.Low-affinity, Smith antigen-specific B cells are tolerized by dendritic cells and macrophages.Regulatory B cells (B10 cells) have a suppressive role in murine lupus: CD19 and B10 cell deficiency exacerbates systemic autoimmunity.Role of Syk in B-cell development and antigen-receptor signalingSuppression of phosphatidylinositol 3,4,5-trisphosphate production is a key determinant of B cell anergy.EndoU is a novel regulator of AICD during peripheral B cell selection.The role of B cells in systemic sclerosis.Spleen tyrosine kinase: an Src family of non-receptor kinase has multiple functions and represents a valuable therapeutic target in the treatment of autoimmune and inflammatory diseases.Activation-induced cytidine deaminase and aberrant germinal center selection in the development of humoral autoimmunitiesRationale of anti-CD19 immunotherapy: an option to target autoreactive plasma cells in autoimmunity.B lymphocytes: development, tolerance, and their role in autoimmunity-focus on systemic lupus erythematosus.Abnormal B lymphocyte activation and function in systemic sclerosis.B lymphocytes in systemic sclerosis: Abnormalities and therapeutic targets.Challenges and opportunities in treating inflammation associated with pulmonary hypertension.IgM and stromal cell-associated heparan sulfate/heparin as complement-independent ligands for CD19.Low and nontoxic levels of ionic mercury interfere with the regulation of cell growth in the WEHI-231 B-cell lymphoma.Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells.Peripheral CD19hi B cells exhibit activated phenotype and functionality in promoting IgG and IgM production in human autoimmune diseasesThe CD19 signalling molecule is elevated in NOD mice and controls type 1 diabetes development.B-cell-specific transgene expression using a self-inactivating retroviral vector with human CD19 promoter and viral post-transcriptional regulatory element.Loss of a single allele of SHIP exacerbates the immunopathology of Pten heterozygous mice.
P2860
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P2860
CD19-regulated signaling thresholds control peripheral tolerance and autoantibody production in B lymphocytes.
description
1997 nî lūn-bûn
@nan
1997年の論文
@ja
1997年学术文章
@wuu
1997年学术文章
@zh-cn
1997年学术文章
@zh-hans
1997年学术文章
@zh-my
1997年学术文章
@zh-sg
1997年學術文章
@yue
1997年學術文章
@zh
1997年學術文章
@zh-hant
name
CD19-regulated signaling thres ...... y production in B lymphocytes.
@ast
CD19-regulated signaling thres ...... y production in B lymphocytes.
@en
type
label
CD19-regulated signaling thres ...... y production in B lymphocytes.
@ast
CD19-regulated signaling thres ...... y production in B lymphocytes.
@en
prefLabel
CD19-regulated signaling thres ...... y production in B lymphocytes.
@ast
CD19-regulated signaling thres ...... y production in B lymphocytes.
@en
P2093
P2860
P356
P1476
CD19-regulated signaling thres ...... y production in B lymphocytes.
@en
P2093
P2860
P304
P356
10.1084/JEM.186.11.1923
P407
P577
1997-12-01T00:00:00Z