Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells.
about
Genetic requirements for the development and differentiation of interleukin-17-producing γδ T cellsThe SLE variant Ala71Thr of BLK severely decreases protein abundance and binding to BANK1 through impairment of the SH3 domain function.BANK1 and BLK act through phospholipase C gamma 2 in B-cell signalingAssociation between a C8orf13-BLK polymorphism and polymyositis/dermatomyositis in the Japanese population: an additive effect with STAT4 on disease susceptibility.Reduced B lymphoid kinase (Blk) expression enhances proinflammatory cytokine production and induces nephrosis in C57BL/6-lpr/lpr mice.Concordance of increased B1 cell subset and lupus phenotypes in mice and humans is dependent on BLK expression levels.The autoimmunity-associated BLK haplotype exhibits cis-regulatory effects on mRNA and protein expression that are prominently observed in B cells early in development.Two functional lupus-associated BLK promoter variants control cell-type- and developmental-stage-specific transcription.Agammaglobulinemia: causative mutations and their implications for novel therapies.Pharmacology of Src family kinases and therapeutic implications of their modulators.Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis.The Genotype and Phenotype (GaP) registry: a living biobank for the analysis of quantitative traits.Autoimmune disease-associated haplotypes of BLK exhibit lowered thresholds for B cell activation and expansion of Ig class-switched B cells.The rheumatic disease-associated FAM167A-BLK locus encodes DIORA-1, a novel disordered protein highly expressed in bronchial epithelium and alveolar macrophages.Plasma Cell Differentiation Pathways in Systemic Lupus Erythematosus.
P2860
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P2860
Blk haploinsufficiency impairs the development, but enhances the functional responses, of MZ B cells.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Blk haploinsufficiency impairs ...... onal responses, of MZ B cells.
@en
type
label
Blk haploinsufficiency impairs ...... onal responses, of MZ B cells.
@en
prefLabel
Blk haploinsufficiency impairs ...... onal responses, of MZ B cells.
@en
P2093
P2860
P356
P1476
Blk haploinsufficiency impairs ...... onal responses, of MZ B cells.
@en
P2093
Alexander C Maue
Elizabeth M Samuelson
Renee M Laird
Rosemary Rochford
Sandra M Hayes
P2860
P2888
P304
P356
10.1038/ICB.2011.76
P577
2011-09-06T00:00:00Z
P5875
P6179
1052356208