Chemoproteomics Reveals Novel Protein and Lipid Kinase Targets of Clinical CDK4/6 Inhibitors in Lung Cancer.
about
CDK4/6 inhibitor-SHR6390 exerts potent antitumor activity in esophageal squamous cell carcinoma by inhibiting phosphorylated Rb and inducing G1 cell cycle arrestCDK4/6 and autophagy inhibitors synergistically induce senescence in Rb positive cytoplasmic cyclin E negative cancers.Cyclin Dependent Kinase 9 Inhibitors for Cancer TherapyRibociclib (LEE011): Mechanism of Action and Clinical Impact of This Selective Cyclin-Dependent Kinase 4/6 Inhibitor in Various Solid Tumors.The Strange Case of CDK4/6 Inhibitors: Mechanisms, Resistance, and Combination Strategies.Dual Targeting of WEE1 and PLK1 by AZD1775 Elicits Single Agent Cellular Anticancer Activity.Proteome-wide Profiling of Clinical PARP Inhibitors Reveals Compound-Specific Secondary Targets.Palbociclib induces activation of AMPK and inhibits hepatocellular carcinoma in a CDK4/6-independent manner.Combined CDK4/6 and mTOR Inhibition Is Synergistic against Glioblastoma via Multiple Mechanisms.Synthesis and Anti-Proliferative Effects of Mono- and Bis-Purinomimetics Targeting Kinases.Therapeutic Challenge With a CDK 4/6 Inhibitor Induces an RB-dependent SMAC Mediated Apoptotic Response in Non-Small Cell Lung Cancer.A hypothesis-driven approach identifies CDK4 and CDK6 inhibitors as candidate drugs for treatments of adrenocortical carcinomas.CAR-T cells and combination therapies: What's next in the immunotherapy revolution?Inhibiting CDK in Cancer Therapy: Current Evidence and Future Directions.Competitive Kinase Enrichment Proteomics Reveals that Abemaciclib Inhibits GSK3β and Activates WNT Signaling.Polypharmacology-based ceritinib repurposing using integrated functional proteomics.Discovery and Pharmacological Characterisation of a Novel Series of Highly Selective Inhibitors of Cyclin-Dependent Kinases 4 and 6 as Anticancer Agents.Characterization of CDK(5) inhibitor, 20-223 (aka CP668863) for colorectal cancer therapy.Ceritinib Enhances the Efficacy of Trametinib in BRAF/NRAS-Wild-Type Melanoma Cell Lines.Thermal proteome profiling of breast cancer cells reveals proteasomal activation by CDK4/6 inhibitor palbociclib.
P2860
Q33759276-45B5EEFB-F765-4277-980E-0FA7352E4657Q33851230-D50EF34D-D8CD-4C9A-B194-B78D12951F47Q36015334-954473BB-9C85-4E16-9C18-3B95200CFE2AQ38870282-C5EDE243-E0DC-4754-AC51-C546BD1CFFCEQ39183079-7833B1C3-6FD0-489A-B1A7-6CD62C49514EQ40180908-6A24E388-7FDC-498B-9B94-B70E4705ECE3Q40465701-71071257-6877-4977-9D7A-BB00FAB6984EQ41194460-F37BB61F-560D-4760-9751-5F773B9C3A99Q45065453-6C10E026-7C07-4170-A238-7BFC76CA4B6DQ47161171-D3047DDB-FEFA-4028-ADAD-BDF210468F85Q47223157-239F61F5-EA52-46F3-9CE7-5EDF30053F04Q47239499-8D60449F-0441-4F41-BD8C-D7A2A9F2E247Q47285613-6519554A-1ACF-49D0-BC13-04500F0002CDQ47316489-FDDD638E-A090-425D-8AC8-FC850DE09DAEQ47406875-13A3754B-5E74-40BF-AA32-D29A73AD1219Q47678215-A83E68BE-4CCA-4692-A782-49CE3F3ABC63Q47963513-51F06909-EED6-490F-9C7C-6DBCE26BF877Q49536215-1FCBC516-24E6-42B7-92AF-8009CA9F380EQ50042437-63007322-8348-488C-B2C7-1C8FFC9D7B3FQ52718493-510C9D52-12FF-4CB3-80C2-32D089C3CAAE
P2860
Chemoproteomics Reveals Novel Protein and Lipid Kinase Targets of Clinical CDK4/6 Inhibitors in Lung Cancer.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
Chemoproteomics Reveals Novel ...... 4/6 Inhibitors in Lung Cancer.
@ast
Chemoproteomics Reveals Novel ...... 4/6 Inhibitors in Lung Cancer.
@en
type
label
Chemoproteomics Reveals Novel ...... 4/6 Inhibitors in Lung Cancer.
@ast
Chemoproteomics Reveals Novel ...... 4/6 Inhibitors in Lung Cancer.
@en
prefLabel
Chemoproteomics Reveals Novel ...... 4/6 Inhibitors in Lung Cancer.
@ast
Chemoproteomics Reveals Novel ...... 4/6 Inhibitors in Lung Cancer.
@en
P2093
P2860
P1433
P1476
Chemoproteomics Reveals Novel ...... K4/6 Inhibitors in Lung Cancer
@en
P2093
Claire E Knezevic
Lily L Remsing Rix
Natalia J Sumi
P2860
P304
P356
10.1021/ACSCHEMBIO.5B00368
P577
2015-10-05T00:00:00Z