The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis - Wikidata - awgldk - TriplyDB

The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

http://www.wikidata.org/entity/Q29622875

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Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)A comprehensive glossary of autophagy-related molecules and processes (2nd edition)Adiponectin lowers glucose production by increasing SOGA A new ubiquitin ligase involved in p57KIP2 proteolysis regulates osteoblast cell differentiation 14-3-3 interacts with LKB1 via recognizing phosphorylated threonine 336 residue and suppresses LKB1 kinase function Microtubule-associated protein 1S (MAP1S) bridges autophagic components with microtubules and mitochondria to affect autophagosomal biogenesis and degradation Mammalian autophagy: core molecular machinery and signaling regulation The AMPK signalling pathway coordinates cell growth, autophagy and metabolism Next-generation mTOR inhibitors in clinical oncology: how pathway complexity informs therapeutic strategy The microbiome and butyrate regulate energy metabolism and autophagy in the mammalian colon RSK1 drives p27Kip1 phosphorylation at T198 to promote RhoA inhibition and increase cell motility.MicroRNA-221/222 confers tamoxifen resistance in breast cancer by targeting p27Kip1 AMPK activators: mechanisms of action and physiological activities New Potential Pharmacological Functions of Chinese Herbal Medicines via Regulation of Autophagy Autophagy and Apoptotic Crosstalk: Mechanism of Therapeutic Resistance in HER2-Positive Breast Cancer The Warburg effect and drug resistance Breast Cancer Metabolism and Mitochondrial Activity: The Possibility of Chemoprevention with Metformin Cell Death Conversion under Hypoxic Condition in Tumor Development and Therapy Autophagy signal transduction by ATG proteins: from hierarchies to networks Autophagy paradox and ceramide AMP-activated protein kinase: a target for drugs both ancient and modern mTOR-dependent cell survival mechanisms AMP-activated protein kinase: an energy sensor that regulates all aspects of cell function Mitophagy: mechanisms, pathophysiological roles, and analysis Autophagy and cancer Rottlerin and cancer: novel evidence and mechanisms AMPK: a target for drugs and natural products with effects on both diabetes and cancer Autophagy: a targetable linchpin of cancer cell metabolism Two-way communication between the metabolic and cell cycle machineries: the molecular basis Targeting autophagy for the treatment of liver diseases Nutrient sensing, metabolism, and cell growth control Mechanisms of disseminated cancer cell dormancy: an awakening field The role of autophagy in Drosophila metamorphosis Caspases uncouple p27(Kip1) from cell cycle regulated degradation and abolish its ability to stimulate cell migration and invasion Role of T198 modification in the regulation of p27(Kip1) protein stability and function The multifaceted roles of autophagy in tumors-implications for breast cancer.Autophagy in the Pathogenesis of Disease Positive or negative roles of different cyclin-dependent kinase Pho85-cyclin complexes orchestrate induction of autophagy in Saccharomyces cerevisiae Distinctive properties of metastasis-initiating cells Insulin-Sensitizers, Polycystic Ovary Syndrome and Gynaecological Cancer Risk

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P2860

The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis

http://www.wikidata.org/entity/Q29622875

description

2007 nî lūn-bûn

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2007 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2007 թվականի փետրվարին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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The energy sensing LKB1-AMPK p ...... o enter autophagy or apoptosis

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The energy sensing LKB1-AMPK p ...... o enter autophagy or apoptosis

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The energy sensing LKB1-AMPK p ...... o enter autophagy or apoptosis

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The energy sensing LKB1-AMPK p ...... o enter autophagy or apoptosis

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prefLabel

The energy sensing LKB1-AMPK p ...... o enter autophagy or apoptosis

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The energy sensing LKB1-AMPK p ...... o enter autophagy or apoptosis

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Nature Cell Biology

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The energy sensing LKB1-AMPK p ...... o enter autophagy or apoptosis

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Ding Z

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Dumont DJ

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Gutterman JU

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Hennessy B

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Kondo S

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Larrea M

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Liang J

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Mills GB

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Shao SH

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Slingerland JM

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P2860

C-terminal phosphorylation controls the stability and function of p27kip1

LKB1 is a master kinase that activates 13 kinases of the AMPK subfamily, including MARK/PAR-1

Cleavage of p21Cip1/Waf1 and p27Kip1 mediates apoptosis in endothelial cells through activation of Cdk2: role of a caspase cascade

LC3, a mammalian homologue of yeast Apg8p, is localized in autophagosome membranes after processing

A restriction point for control of normal animal cell proliferation

The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress

TSC2 mediates cellular energy response to control cell growth and survival

Upstream and downstream of mTOR

Inhibition of autophagy in mitotic animal cells

Growth factor regulation of autophagy and cell survival in the absence of apoptosis

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218-24

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2025740

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10.1038/NCB1537

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2

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9

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1045284002

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17237771

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phosphorylation