Neuronal SH2B1 is essential for controlling energy and glucose homeostasis. - Wikidata - awgldk - TriplyDB

Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.

Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.

http://www.wikidata.org/entity/Q35576170

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Molecular basis of signaling specificity of insulin and IGF receptors: neglected corners and recent advances Large, rare chromosomal deletions associated with severe early-onset obesity Six new loci associated with body mass index highlight a neuronal influence on body weight regulation Recent advances in understanding leptin signaling and leptin resistance Regulation of insulin and type 1 insulin-like growth factor signaling and action by the Grb10/14 and SH2B1/B2 adaptor proteins Leptin signaling and leptin resistance Brain regulation of energy balance and body weight.Energy metabolism in the liver Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index The SH2B1 obesity locus is associated with myocardial infarction in diabetic patients and with NO synthase activity in endothelial cells Chromosome 16p11.2 deletions: another piece in the genetic puzzle of childhood obesity Recent progress in the genetics of common obesity SH2B regulation of growth, metabolism, and longevity in both insects and mammals.Genomic insights into early-onset obesity.Studies of metabolic phenotypic correlates of 15 obesity associated gene variants SH2B1 regulation of energy balance, body weight, and glucose metabolism.Assessment of feeding behavior in laboratory mice Evaluation of genetic susceptibility loci for obesity in Chinese women.The adaptor protein SH2B3 (Lnk) negatively regulates neurite outgrowth of PC12 cells and cortical neurons.Functional characterization of obesity-associated variants involving the α and β isoforms of human SH2B1 MC4R variant is associated with BMI but not response to resistance training in young females.Critical role of the Src homology 2 (SH2) domain of neuronal SH2B1 in the regulation of body weight and glucose homeostasis in mice.Glucose enhances leptin signaling through modulation of AMPK activity.Mutation screen in the GWAS derived obesity gene SH2B1 including functional analyses of detected variants.Implication of SH2B1 gene polymorphism studies in gestational diabetes mellitus in Saudi pregnant women.Screening for coding variants in FTO and SH2B1 genes in Chinese patients with obesity.Novel obesity risk loci do not determine distribution of body fat depots: a whole-body MRI/MRS study.Hepatic SH2B1 and SH2B2 regulate liver lipid metabolism and VLDL secretion in mice Genetics of Obesity: What have we Learned?Structural Chromosome Abnormalities Associated with Obesity: Report of Four New subjects and Review of Literature.Pleiotropy of type 2 diabetes with obesity Identification of SH2B1β as a focal adhesion protein that regulates focal adhesion size and number.Fine Mapping of a GWAS-Derived Obesity Candidate Region on Chromosome 16p11.2.Hepatic TRAF2 regulates glucose metabolism through enhancing glucagon responses.Exploring genetic markers of adult obesity risk in black adolescent South Africans-the Birth to Twenty Cohort.Herbal constituent sequoyitol improves hyperglycemia and glucose intolerance by targeting hepatocytes, adipocytes, and β-cells Neuronal Cbl controls biosynthesis of insulin-like peptides in Drosophila melanogaster.Estimation of genetic effects on BMI during adolescence in an ethnically diverse cohort: The National Longitudinal Study of Adolescent Health Characterizing gene-gene interactions in a statistical epistasis network of twelve candidate genes for obesity.Human SH2B1 mutations are associated with maladaptive behaviors and obesity.

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P2860

Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.

http://www.wikidata.org/entity/Q35576170

description

2007 nî lūn-bûn

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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2007年论文

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2007年论文

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name

Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.

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Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.

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type

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Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.

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Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.

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Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.

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Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.

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P1433

Journal of Clinical Investigation

P1476

Neuronal SH2B1 is essential for controlling energy and glucose homeostasis.

@en

P2093

Decheng Ren

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Liangyou Rui

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Minghua Li

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Yingjiang Zhou

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Zhiqin Li

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P2860

Positional cloning of the mouse obese gene and its human homologue

TYK2 and JAK2 are substrates of protein-tyrosine phosphatase 1B

PTP1B regulates leptin signal transduction in vivo

Interaction of SH2-Bbeta with RET is involved in signaling of GDNF-induced neurite outgrowth

SH2-Balpha is an insulin-receptor adapter protein and substrate that interacts with the activation loop of the insulin-receptor kinase

Cloning and characterization of APS, an adaptor molecule containing PH and SH2 domains that is tyrosine phosphorylated upon B-cell receptor stimulation

Kinase activation through dimerization by human SH2-B

SH2-B is required for both male and female reproduction

Regulation of Jak2 through the ubiquitin-proteasome pathway involves phosphorylation of Jak2 on Y1007 and interaction with SOCS-1.

Dysregulation of insulin receptor substrate 2 in beta cells and brain causes obesity and diabetes

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397-406

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10.1172/JCI29417

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2

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117

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17235396

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1765516

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