Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design.

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Trypanosoma brucei CYP51: Essentiality and Targeting Therapy in an Experimental Model Enzyme Tunnels and Gates As Relevant Targets in Drug Design.Human sterol 14α-demethylase as a target for anticancer chemotherapy: towards structure-aided drug design.

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Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design.

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2015 nî lūn-bûn

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2015年の論文

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年学术文章

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2015年學術文章

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name

Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design.

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Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design.

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Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design.

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Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design.

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Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design.

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Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design.

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P1476

Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design

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P2093

Galina I Lepesheva

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Vlad Cojocaru

http://www.w3.org/2001/XMLSchema#string

Xiaofeng Yu

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P2860

Structural basis of human CYP51 inhibition by antifungal azoles

VNI cures acute and chronic experimental Chagas disease

Membrane position of ibuprofen agrees with suggested access path entrance to cytochrome P450 2C9 active site

Crystal structures of Trypanosoma brucei sterol 14alpha-demethylase and implications for selective treatment of human infections

X-ray Structure of 4,4'-Dihydroxybenzophenone Mimicking Sterol Substrate in the Active Site of Sterol 14 -Demethylase (CYP51)

Structural Insights into Inhibition of Sterol 14 -Demethylase in the Human Pathogen Trypanosoma cruzi

Substrate Preferences and Catalytic Parameters Determined by Structural Characteristics of Sterol 14α-Demethylase (CYP51) from Leishmania infantum

Structural complex of sterol 14 -demethylase (CYP51) with 14 -methylenecyclopropyl- 7-24, 25-dihydrolanosterol

Antitrypanosomal Lead Discovery: Identification of a Ligand-Efficient Inhibitor of Trypanosoma cruzi CYP51 and Parasite Growth

Architecture of a single membrane spanning cytochrome P450 suggests constraints that orient the catalytic domain relative to a bilayer

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scholarly article

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10.1016/J.BBAGEN.2015.10.015

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English

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1 Pt A

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1860

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Rebecca C Wade

Ghulam Mustafa

Prajwal Nandekar

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2015-10-19T00:00:00Z

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283209100

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26493722

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Trypanosoma brucei

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4689311

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Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design.

about

P2860

P2860

Ligand tunnels in T. brucei and human CYP51: Insights for parasite-specific drug design.

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