Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivity
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Directing Group-Controlled Regioselectivity in an Enzymatic C–H Bond OxygenationAdvances in the directed evolution of proteins.Enhancing the efficiency and regioselectivity of P450 oxidation catalysts by unnatural amino acid mutagenesis.Cell foundry with high product specificity and catalytic activity for 21-deoxycortisol biotransformation.Regio- and stereoselective hydroxylation of 10-undecenoic acid with a light-driven P450 BM3 biocatalyst yielding a valuable synthon for natural product synthesis.Enzyme-controlled nitrogen-atom transfer enables regiodivergent C-H amination.Enzymatic C(sp(3))-H Amination: P450-Catalyzed Conversion of Carbonazidates into Oxazolidinones.cis-Decalin oxidation as a stereochemical probe of in-MOF versus on-MOF catalysis.Discovery of potent parthenolide-based antileukemic agents enabled by late-stage P450-mediated C-H functionalization.Controlling substrate specificity and product regio- and stereo-selectivities of P450 enzymes without mutagenesis.P450-catalyzed intramolecular sp(3) C-H amination with arylsulfonyl azide substrates.Directed evolution of cytochrome P450 enzymes for biocatalysis: exploiting the catalytic versatility of enzymes with relaxed substrate specificity.Accessing Drug Metabolites via Transition-Metal Catalyzed C-H Oxidation: The Liver as Synthetic Inspiration.Enzymatic site-selectivity enabled by structure-guided directed evolution.A visible-light-promoted radical reaction system for azidation and halogenation of tertiary aliphatic C-H bondsBiochemical and Structural Characterization of MycCI, a Versatile P450 Biocatalyst from the Mycinamicin Biosynthetic Pathway.Chemoenzymatic synthesis and antileukemic activity of novel C9- and C14-functionalized parthenolide analogs.Enzymatic hydroxylation of an unactivated methylene C-H bond guided by molecular dynamics simulations.Aldehyde and Ketone Synthesis by P450-Catalyzed Oxidative Deamination of Alkyl Azides.Highly Enantioselective Oxidation of Nonactivated Aliphatic C-H Bonds with Hydrogen Peroxide Catalyzed by Manganese Complexes.Insights into electron leakage in the reaction cycle of cytochrome P450 BM3 revealed by kinetic modeling and mutagenesis.Catalyst-Controlled Site-Selective Bond Activation.Enantioselective Total Synthesis of Nigelladine A via Late-Stage C-H Oxidation Enabled by an Engineered P450 Enzyme.Stabilization of the Reductase Domain in the Catalytically Self-Sufficient Cytochrome P450BM3 via Consensus-Guided Mutagenesis.The Oxidation of Hydrophobic Aromatic Substrates by Using a Variant of the P450 Monooxygenase CYP101B1.Chemistry. Re-engineering nature's catalysts.Active Site Crowding of Cytochrome P450 3A4 as a Strategy To Alter Its Selectivity.Mechanistic Study of the Stereoselective Hydroxylation of [2-2 H1 ,3-2 H1 ]Butanes Catalyzed by Cytochrome P450 BM3 Variants.Selective oxidation of aliphatic C-H bonds in alkylphenols by a chemomimetic biocatalytic system.Hydroxylation of anilides by engineered cytochrome P450BM3.What are the Limitations of Enzymes in Synthetic Organic Chemistry?The self-sufficient P450 RhF expressed in a whole cell system selectively catalyses the 5-hydroxylation of diclofenac.Engineering of p450pyr hydroxylase for the highly regio- and enantioselective subterminal hydroxylation of alkanes.Biocatalytic oxidation reactions - a Chemist's perspective.Direct Hydroxylation of Benzene to Phenol by Cytochrome P450BM3 Triggered by Amino Acid Derivatives.Reagent-dictated site selectivity in intermolecular aliphatic C–H functionalizations using nitrogen-centered radicals† †Electronic supplementary information (ESI) available: Experimental details and characterization data. CCDC 1553660. For ESI and c
P2860
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P2860
Controlled oxidation of remote sp3 C-H bonds in artemisinin via P450 catalysts with fine-tuned regio- and stereoselectivity
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
@zh
2012年學術文章
@zh-hant
name
Controlled oxidation of remote ...... d regio- and stereoselectivity
@ast
Controlled oxidation of remote ...... d regio- and stereoselectivity
@en
type
label
Controlled oxidation of remote ...... d regio- and stereoselectivity
@ast
Controlled oxidation of remote ...... d regio- and stereoselectivity
@en
prefLabel
Controlled oxidation of remote ...... d regio- and stereoselectivity
@ast
Controlled oxidation of remote ...... d regio- and stereoselectivity
@en
P2093
P2860
P356
P1476
Controlled oxidation of remote ...... d regio- and stereoselectivity
@en
P2093
Brian M Shafer
Harry A Stern
Kaidong Zhang
Matthew D Demars
P2860
P304
18695-18704
P356
10.1021/JA3073462
P407
P50
P577
2012-11-02T00:00:00Z