A mutational analysis of the binding of staphylococcal enterotoxins B and C3 to the T cell receptor beta chain and major histocompatibility complex class II.
about
Gram-positive and gram-negative bacterial toxins in sepsis: a brief reviewBinding of superantigen toxins into the CD28 homodimer interface is essential for induction of cytokine genes that mediate lethal shockCrystal structure of a superantigen bound to MHC class II displays zinc and peptide dependenceStructural and functional role of threonine 112 in a superantigen Staphylococcus aureus enterotoxin BStructural basis for abrogated binding between staphylococcal enterotoxin A superantigen vaccine and MHC-IIαCrystal Structure of Staphylococcal Enterotoxin G (SEG) in Complex with a Mouse T-cell Receptor ChainMolecular Basis of a Million-Fold Affinity Maturation Process in a Protein–Protein InteractionCrystallographic and mutational data show that the streptococcal pyrogenic exotoxin J can use a common binding surface for T-cell receptor binding and dimerization.Uptake and intracellular trafficking of superantigens in dendritic cells.An unbiased systems genetics approach to mapping genetic loci modulating susceptibility to severe streptococcal sepsis.A mutant of staphylococcal enterotoxin C devoid of bacterial superantigenic activity elicits a Th2 immune response for protection against Staphylococcus aureus infection.Understanding the mechanism of action of bacterial superantigens from a decade of research.MAIT cells launch a rapid, robust and distinct hyperinflammatory response to bacterial superantigens and quickly acquire an anergic phenotype that impedes their cognate antimicrobial function: Defining a novel mechanism of superantigen-induced immunStructural basis for the recognition of superantigen streptococcal pyrogenic exotoxin A (SpeA1) by MHC class II molecules and T-cell receptors.Biochemical and biological properties of Staphylococcal enterotoxin K.Interplay between superantigens and immunoreceptors.Staphylococcal and streptococcal superantigen exotoxinsEvaluation of a recombinant double mutant of staphylococcal enterotoxin B (SEB-H32Q/K173E) with enhanced antitumor activity effects and decreased pyrexia.Immune regulatory loops determine productive interactions within human T lymphocyte-dendritic cell clustersThe tumor targeted superantigen ABR-217620 selectively engages TRBV7-9 and exploits TCR-pMHC affinity mimicry in mediating T cell cytotoxicity.Bacterial superantigens.Structure of Staphylococcal Enterotoxin E in Complex with TCR Defines the Role of TCR Loop Positioning in Superantigen Recognition.Antigen targeting to major histocompatibility complex class II with streptococcal mitogenic exotoxin Z-2 M1, a superantigen-based vaccine carrierTwo common structural motifs for TCR recognition by staphylococcal enterotoxins.Immunity to Staphylococcus aureus secreted proteins protects rabbits from serious illnesses.Mapping the energy of superantigen Staphylococcus enterotoxin C3 recognition of an alpha/beta T cell receptor using alanine scanning mutagenesis.A peptide antagonist of CD28 signaling attenuates toxic shock and necrotizing soft-tissue infection induced by Streptococcus pyogenes.Genotype and enterotoxigenicity of Staphylococcus epidermidis isolate from ready to eat meat productsCD28: direct and critical receptor for superantigen toxinsUpdate on staphylococcal superantigen-induced signaling pathways and therapeutic interventions.Superantigens hyperinduce inflammatory cytokines by enhancing the B7-2/CD28 costimulatory receptor interaction.Bacterial superantigen toxins induce a lethal cytokine storm by enhancing B7-2/CD28 costimulatory receptor engagement, a critical immune checkpoint.The construction of a bifunctional fusion protein consisting of SEC2 and EGFP.FDA-approved immunosuppressants targeting staphylococcal superantigens: mechanisms and insights.CD1d-independent activation of mouse and human iNKT cells by bacterial superantigens.Attenuation of massive cytokine response to the staphylococcal enterotoxin B superantigen by the innate immunomodulatory protein lactoferrin.Rapid and Rigorous IL-17A Production by a Distinct Subpopulation of Effector Memory T Lymphocytes Constitutes a Novel Mechanism of Toxic Shock Syndrome Immunopathology.Design of chimeric receptor mimics with different TcRVbeta isoforms. Type-specific inhibition of superantigen pathogenesis.Role of the T cell receptor ligand affinity in T cell activation by bacterial superantigens.Analysis of functional regions of YPM, a superantigen derived from gram-negative bacteria.
P2860
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P2860
A mutational analysis of the binding of staphylococcal enterotoxins B and C3 to the T cell receptor beta chain and major histocompatibility complex class II.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
A mutational analysis of the b ...... ompatibility complex class II.
@ast
A mutational analysis of the b ...... ompatibility complex class II.
@en
type
label
A mutational analysis of the b ...... ompatibility complex class II.
@ast
A mutational analysis of the b ...... ompatibility complex class II.
@en
prefLabel
A mutational analysis of the b ...... ompatibility complex class II.
@ast
A mutational analysis of the b ...... ompatibility complex class II.
@en
P2093
P2860
P356
P1476
A mutational analysis of the b ...... ompatibility complex class II.
@en
P2093
G A Bohach
K Karjalainen
M I Lebedeva
P M Lavoie
P M Schlievert
R A Mariuzza
R P Sékaly
P2860
P304
P356
10.1084/JEM.187.6.823
P407
P50
P577
1998-03-01T00:00:00Z