Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulation.
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Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosisRole of biologics in severe eosinophilic asthma - focus on reslizumabIdentification of UNC119 as a novel activator of SRC-type tyrosine kinasesEngagement of the CrkL adapter in interleukin-5 signaling in eosinophils.Chronic lymphocytic leukemia B cells contain anomalous Lyn tyrosine kinase, a putative contribution to defective apoptosis.Eosinophil survival and apoptosis in health and disease.The peptidyl-prolyl isomerase Pin1 facilitates cytokine-induced survival of eosinophils by suppressing Bax activation.Advances in the immunobiology of eosinophils and their role in disease.Priming of eosinophils by GM-CSF is mediated by protein kinase CbetaII-phosphorylated L-plastin.Chemokine and cytokine cooperativity: eosinophil migration in the asthmatic response.Cholesterol selectively regulates IL-5 induced mitogen activated protein kinase signaling in human eosinophilsControlling allergic inflammation by signaling regulation of eosinophils.New approaches in the treatment of asthma.Genomic microarrays: arraying order in biological chaos?Intracellular signal transduction in eosinophils and its clinical significance.A review of antisense therapeutic interventions for molecular biological targets in asthma.Mitogen-activated protein kinase signalling and ERK1/2 bistability in asthma.Cross-talk between ICAM-1 and granulocyte-macrophage colony-stimulating factor receptor signaling modulates eosinophil survival and activation.Biochemical assessment of intracellular signal transduction pathways in eosinophils: implications for pharmacotherapy.Lyn kinase promotes erythroblast expansion and late-stage development.Functions of the Lyn tyrosine kinase in health and diseaseAntisense- and RNA interference-based therapeutic strategies in allergy.In vitro effects of budesonide on eosinophil-basophil lineage commitment.Oral mucosa lesions in hypereosinophilic syndrome--an update.Human airway eosinophils exhibit preferential reduction in STAT signaling capacity and increased CISH expression.The Peripheral Blood Eosinophil Proteome.IL-5- and eosinophil-mediated inflammation: from discovery to therapy.Lyn regulates mucus secretion and MUC5AC via the STAT6 signaling pathway during allergic airway inflammation.The signaling mechanism of eosinophil activation.Primary prevention of allergic diseases: current concepts and mechanisms.Molecular and clinical rationale for therapeutic targeting of interleukin-5 and its receptor.Regulation of spontaneous eosinophil apoptosis-a neglected area of importance.Microarray analysis of eosinophils reveals a number of candidate survival and apoptosis genes.Spred-1 negatively regulates allergen-induced airway eosinophilia and hyperresponsiveness.Inhibitory effects of costunolide isolated from Laurus nobilis on IgE-induced degranulation of mast cell-like RBL-2H3 cells and the growth of Y16 pro-B cells.Chemoattractant-induced signaling via the Ras-ERK and PI3K-Akt networks, along with leukotriene C4 release, is dependent on the tyrosine kinase Lyn in IL-5- and IL-3-primed human blood eosinophils.MAPK activation is involved in posttranscriptional regulation of RSV-induced RANTES gene expression.Analysis of mechanisms involved in the prevention of gamma irradiation-induced apoptosis by hGM-CSF.Opposing effects of sodium salicylate and haematopoietic cytokines IL-3, IL-5 and GM-CSF on mitogen-activated protein kinases and apoptosis of EoL-1 cells.Transforming Growth Factor-β1 Antagonizes Interleukin-5 Pro-Survival Signaling by Activating Calpain-1 in Primary Human Eosinophils.
P2860
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P2860
Lyn, Jak2, and Raf-1 kinases are critical for the antiapoptotic effect of interleukin 5, whereas only Raf-1 kinase is essential for eosinophil activation and degranulation.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Lyn, Jak2, and Raf-1 kinases a ...... activation and degranulation.
@ast
Lyn, Jak2, and Raf-1 kinases a ...... activation and degranulation.
@en
type
label
Lyn, Jak2, and Raf-1 kinases a ...... activation and degranulation.
@ast
Lyn, Jak2, and Raf-1 kinases a ...... activation and degranulation.
@en
prefLabel
Lyn, Jak2, and Raf-1 kinases a ...... activation and degranulation.
@ast
Lyn, Jak2, and Raf-1 kinases a ...... activation and degranulation.
@en
P2093
P2860
P356
P1476
Lyn, Jak2, and Raf-1 kinases a ...... activation and degranulation.
@en
P2093
B Olszewska-Pazdrak
R P Garofalo
S Stafford
P2860
P304
P356
10.1084/JEM.188.3.421
P407
P577
1998-08-01T00:00:00Z