A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.
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A chemical with proven clinical safety rescues Down-syndrome-related phenotypes in through DYRK1A inhibitionSelective inhibition of the kinase DYRK1A by targeting its folding processSerpinB1 Promotes Pancreatic β Cell ProliferationHuman pancreatic beta-like cells converted from fibroblasts.Biphasic decline of β-cell function with age in euglycemic nonobese diabetic mice parallels diabetes onsetDirect effect of glucocorticoids on glucose-activated adult rat β-cells increases their cell number and their functional mass for transplantation.The Transcription Factor Nfatc2 Regulates β-Cell Proliferation and Genes Associated with Type 2 Diabetes in Mouse and Human Islets.High-throughput Functional Genomics Identifies Regulators of Primary Human Beta Cell Proliferation.PKCζ Is Essential for Pancreatic β-Cell Replication During Insulin Resistance by Regulating mTOR and Cyclin-D2Early and Late G1/S Cyclins and Cdks Act Complementarily to Enhance Authentic Human β-Cell Proliferation and Expansion.Inhibition of DYRK1A Stimulates Human β-Cell ProliferationReplicative capacity of β-cells and type 1 diabetes.The Genetic Program of Pancreatic β-Cell Replication In VivoHarmine Induces Adipocyte Thermogenesis through RAC1-MEK-ERK-CHD4 Axis.A Pdx-1-Regulated Soluble Factor Activates Rat and Human Islet Cell Proliferation.Evidence for Loss in Identity, De-Differentiation, and Trans-Differentiation of Islet β-Cells in Type 2 Diabetes.Histone chaperone ASF1B promotes human β-cell proliferation via recruitment of histone H3.3.A High-content In Vitro Pancreatic Islet β-cell Replication Discovery Platform.Development of Cell-Based High-Throughput Chemical Screens for Protection Against Cisplatin-Induced Ototoxicity.Single-Cell Transcriptomics of the Human Endocrine Pancreas.Insulin Signaling Regulates the FoxM1/PLK1/CENP-A Pathway to Promote Adaptive Pancreatic β Cell Proliferation.Inhibition of DYRK1A and GSK3B induces human β-cell proliferation.Novel factors modulating human β-cell proliferation.Systematic single-cell analysis provides new insights into heterogeneity and plasticity of the pancreas.Human beta cell mass and function in diabetes: Recent advances in knowledge and technologies to understand disease pathogenesis.Interrogating islets in health and disease with single-cell technologiesDifferent developmental histories of beta-cells generate functional and proliferative heterogeneity during islet growth.Single-Cell Mass Cytometry Analysis of the Human Endocrine Pancreas.Definition of a Skp2-c-Myc Pathway to Expand Human Beta-cellsHarmine stimulates proliferation of human neural progenitors.Identification of the matricellular protein Fibulin-5 as a target molecule of glucokinase-mediated calcineurin/NFAT signaling in pancreatic islets.Insights into beta cell regeneration for diabetes via integration of molecular landscapes in human insulinomas.Development of a reliable automated screening system to identify small molecules and biologics that promote human β-cell regenerationSignals in the pancreatic islet microenvironment influence β-cell proliferation.Structure-Based Design and Synthesis of Harmine Derivatives with Different Selectivity Profiles in Kinase versus Monoamine Oxidase Inhibition.Genetic Disruption of Adenosine Kinase in Mouse Pancreatic β-Cells Protects Against High-Fat Diet-Induced Glucose Intolerance.Pancreatic β Cell Regeneration as a Possible Therapy for Diabetes.β cell self-renewal: Cyclin D2 to the rescue.Regenerative medicine and cell-based approaches to restore pancreatic function.(Re)generating Human Beta Cells: Status, Pitfalls, and Perspectives.
P2860
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P2860
A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.
description
2015 nî lūn-bûn
@nan
2015年の論文
@ja
2015年学术文章
@wuu
2015年学术文章
@zh-cn
2015年学术文章
@zh-hans
2015年学术文章
@zh-my
2015年学术文章
@zh-sg
2015年學術文章
@yue
2015年學術文章
@zh
2015年學術文章
@zh-hant
name
A high-throughput chemical scr ...... creatic beta cell replication.
@ast
A high-throughput chemical scr ...... creatic beta cell replication.
@en
type
label
A high-throughput chemical scr ...... creatic beta cell replication.
@ast
A high-throughput chemical scr ...... creatic beta cell replication.
@en
prefLabel
A high-throughput chemical scr ...... creatic beta cell replication.
@ast
A high-throughput chemical scr ...... creatic beta cell replication.
@en
P2093
P2860
P356
P1433
P1476
A high-throughput chemical scr ...... creatic beta cell replication.
@en
P2093
Aaron Bender
Adolfo Garcia-Ocaña
Andrew F Stewart
Anil Kumar
Dan P Felsenfeld
Donald K Scott
Hongtao Liu
Roberto Sanchez
Sharmila Sivendran
P2860
P2888
P304
P356
10.1038/NM.3820
P407
P577
2015-03-09T00:00:00Z
P5875
P6179
1019488183