Actions of genistein on cystic fibrosis transmembrane conductance regulator channel gating. Evidence for two binding sites with opposite effects.
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Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 from cystic fibrosis lung epithelial cellsCFTR gating II: Effects of nucleotide binding on the stability of open statesAnion transport in heartPotentiation of ΔF508- and G551D-CFTR-Mediated Cl- Current by Novel HydroxypyrazolinesCurcumin and genistein: the combined effects on disease-associated CFTR mutants and their clinical implicationsNovel CFTR chloride channel activators identified by screening of combinatorial libraries based on flavone and benzoquinolizinium lead compounds.Cystic fibrosis: exploiting its genetic basis in the hunt for new therapiesEffects of serine/threonine protein phosphatases on ion channels in excitable membranes.Electrophysiological evidence for the presence of cystic fibrosis transmembrane conductance regulator (CFTR) in mouse sperm.Expression, localization, and functional evaluation of CFTR in bovine corneal endothelial cellsDeltaF508 CFTR processing correction and activity in polarized airway and non-airway cell monolayers.Direct effects of 9-anthracene compounds on cystic fibrosis transmembrane conductance regulator gating.Antagonistic regulation of swelling-activated Cl- current in rabbit ventricle by Src and EGFR protein tyrosine kinases.The block of CFTR by scorpion venom is state-dependentDual activity of aminoarylthiazoles on the trafficking and gating defects of the cystic fibrosis transmembrane conductance regulator chloride channel caused by cystic fibrosis mutations.CFTR Cl- channel functional regulation by phosphorylation of focal adhesion kinase at tyrosine 407 in osmosensitive ion transporting mitochondria rich cells of euryhaline killifish.Potent stimulation and inhibition of the CFTR Cl(-) current by phloxine B.Correction of G551D-CFTR transport defect in epithelial monolayers by genistein but not by CPX or MPB-07.Effect of genistein on basal jejunal chloride secretion in R117H CF mice is sex and route specific.Genistein stimulates jejunum chloride secretion via an Akt-mediated pathway in intact female mice.Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators.Pharmacological approaches to correcting the ion transport defect in cystic fibrosis.Some gating potentiators, including VX-770, diminish ΔF508-CFTR functional expression.Genistein inhibits constitutive and inducible NFkappaB activation and decreases IL-8 production by human cystic fibrosis bronchial gland cells.CFTR channel pharmacology: novel pore blockers identified by high-throughput screening.CFTR regulation in human airway epithelial cells requires integrity of the actin cytoskeleton and compartmentalized cAMP and PKA activity.G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defectsGating of cystic fibrosis transmembrane conductance regulator chloride channels by adenosine triphosphate hydrolysis. Quantitative analysis of a cyclic gating schemeNoncatalytic inhibition of cyclic nucleotide-gated channels by tyrosine kinase induced by genistein.Gramicidin-perforated patch recording revealed the oscillatory nature of secretory Cl- movements in salivary acinar cellsProlonged treatment of cells with genistein modulates the expression and function of the cystic fibrosis transmembrane conductance regulator.Subunit stoichiometry and arrangement in a heteromeric glutamate-gated chloride channel.Gender-specific protection of estrogen against gastric acid-induced duodenal injury: stimulation of duodenal mucosal bicarbonate secretion.Stimulation of murine intestinal secretion by daily genistein injections: gender-dependent differencesHow Phosphorylation and ATPase Activity Regulate Anion Flux though the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).Acute inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel by thyroid hormones involves multiple mechanisms.Molecular modeling of the heterodimer of human CFTR's nucleotide-binding domains using a protein-protein docking approachGating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation.Comparison of cystic fibrosis transmembrane conductance regulator (CFTR) and ciliary beat frequency activation by the CFTR Modulators Genistein, VRT-532, and UCCF-152 in primary sinonasal epithelial cultures.Targeting F508del-CFTR to develop rational new therapies for cystic fibrosis.
P2860
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P2860
Actions of genistein on cystic fibrosis transmembrane conductance regulator channel gating. Evidence for two binding sites with opposite effects.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Actions of genistein on cystic ...... g sites with opposite effects.
@ast
Actions of genistein on cystic ...... g sites with opposite effects.
@en
type
label
Actions of genistein on cystic ...... g sites with opposite effects.
@ast
Actions of genistein on cystic ...... g sites with opposite effects.
@en
prefLabel
Actions of genistein on cystic ...... g sites with opposite effects.
@ast
Actions of genistein on cystic ...... g sites with opposite effects.
@en
P2093
P2860
P356
P1476
Actions of genistein on cystic ...... g sites with opposite effects.
@en
P2093
P2860
P304
P356
10.1085/JGP.111.3.477
P577
1998-03-01T00:00:00Z