Gating of cystic fibrosis transmembrane conductance regulator chloride channels by adenosine triphosphate hydrolysis. Quantitative analysis of a cyclic gating scheme
about
CFTR gating II: Effects of nucleotide binding on the stability of open statesCFTR gating I: Characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (DeltaR-CFTR).Domain-domain associations in cystic fibrosis transmembrane conductance regulator.Cystic fibrosis transmembrane conductance regulator gating requires cytosolic electrolytes.Perturbation of the pore of the cystic fibrosis transmembrane conductance regulator (CFTR) inhibits its atpase activity.Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.CFTR channel gating: incremental progress in irreversible steps.Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain.Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channelCystic fibrosis transmembrane conductance regulator. Structure and function of an epithelial chloride channel.Direct effects of 9-anthracene compounds on cystic fibrosis transmembrane conductance regulator gating.Interaction between permeation and gating in a putative pore domain mutant in the cystic fibrosis transmembrane conductance regulator.Cysteine residues in the nucleotide binding domains regulate the conductance state of CFTR channels.Is cystic fibrosis lung disease caused by abnormal ion composition or abnormal volume?The block of CFTR by scorpion venom is state-dependentRegulation of cystic fibrosis transmembrane conductance regulator single-channel gating by bivalent PDZ-domain-mediated interaction.A conditional probability analysis of cystic fibrosis transmembrane conductance regulator gating indicates that ATP has multiple effects during the gating cycle.Modulation of CFTR gating by permeant ions.Mutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gatingIdentification of a novel post-hydrolytic state in CFTR gating.Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle.G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defectsInsight in eukaryotic ABC transporter function by mutation analysis.On the mechanism of MgATP-dependent gating of CFTR Cl- channelsSevered molecules functionally define the boundaries of the cystic fibrosis transmembrane conductance regulator's NH(2)-terminal nucleotide binding domain.Probing an open CFTR pore with organic anion blockersDual effects of ADP and adenylylimidodiphosphate on CFTR channel kinetics show binding to two different nucleotide binding sites.Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domainsCFTR: covalent modification of cysteine-substituted channels expressed in Xenopus oocytes shows that activation is due to the opening of channels resident in the plasma membraneDistinct Mg(2+)-dependent steps rate limit opening and closing of a single CFTR Cl(-) channel.Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating.The CFTR ion channel: gating, regulation, and anion permeationCysteine scanning of CFTR's first transmembrane segment reveals its plausible roles in gating and permeationVx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle.A mutation in CFTR modifies the effects of the adenylate kinase inhibitor Ap5A on channel gating.Nonequilibrium gating of CFTR on an equilibrium theme.Application of high-resolution single-channel recording to functional studies of cystic fibrosis mutants.A stable ATP binding to the nucleotide binding domain is important for reliable gating cycle in an ABC transporter CFTR.CLC-0 and CFTR: chloride channels evolved from transporters.State-dependent modulation of CFTR gating by pyrophosphate.
P2860
Q24811329-C459BDDC-6413-477D-8DC1-1DA3D48843DEQ25256649-92CCE32F-70B8-4A7E-B02B-96BE0F4FED40Q31047976-1CCFF0DA-B23D-4163-AEF4-8A1C6CFC44E3Q31668598-B091C120-240D-4885-BB7F-5658AB468FC9Q31743298-BBA5FF5F-218B-438D-B6F5-69AD01B53D07Q33666969-5C16E6D7-C2DE-4070-B8F6-D6E0DA210C90Q33683078-8C40C98A-2B8B-437B-83EB-6E0CFB2D52DAQ33723395-CD41D4B4-A956-40A0-B77E-11282231B55EQ33814258-A68F0FC8-935F-47F3-BB7F-4A4A9D2F9F7BQ33830343-371EC4E9-A6CC-427D-B1A9-C07A0B73BD77Q33947514-20FB84AB-079C-4F0E-AAAB-389051FAED0DQ34173438-ACBB0B24-39B8-46A1-BA71-D57AEECA15BCQ34177343-F40489BD-6697-477C-8075-218767FE77BCQ34322971-9182C762-A471-4E4D-BD28-3158E98762B8Q34352436-74405A8C-91AA-4DED-BFDA-92A98E24E92FQ34662162-43939728-F7F7-4EE3-B2F9-847868F3997DQ34755466-E77154FF-8F42-43B8-B19C-139DBBF5E510Q34780305-35002A60-796C-4A33-AC1A-93016AFAC99FQ35018175-A1F5F713-8F99-4190-B20C-ECF09D43BC02Q35931859-9F3DB32F-8B1D-4EF0-9E15-FF4D85BD6C9DQ36295891-C535AE18-34BB-4D3F-A688-52AD0009F5F2Q36296010-5E959B65-80AA-4C50-89D1-32E5BD97BF14Q36379776-8556B383-3050-4B33-BF5F-DDE9F5A2E21FQ36412358-71986F8B-882C-4AA0-8D6A-C22C456D2F7DQ36436335-5BEC7747-6C94-4642-9F0B-852B643B73DCQ36436576-DCEDB309-69FB-4B97-8138-3C8476FCB867Q36436814-BD016BF5-3632-444B-AAE2-9CA112EFDA21Q36444749-C6F67EF5-AAEE-4033-A202-ACE9F85743CBQ36444758-6AA01F9D-9373-47C1-8A82-8CAF65DCB6B4Q36445281-D8F8B059-D653-4453-969B-7CCD69598E75Q36447213-D44FDB33-D4EB-4907-B9EA-924728507F4CQ36488258-90902463-793F-4650-8177-C421D6322FD6Q36621953-D0F44BA2-4112-4FFC-8F5C-A2A65DD1A4F8Q36692979-2EEBA197-9192-4BCC-B38A-7C16A108E6B1Q36981695-24580D33-1782-41EE-98E6-FFA912E22F56Q37061709-1FF4FF38-211F-44E5-8A13-7A2268026816Q37080842-F4F1ADD0-7E54-4E43-B3ED-F3E8FF0AE68EQ37080848-CF104CC2-83D5-4F3B-94F4-5BF66FAA886EQ37129332-D1E38670-4F57-405B-9595-DAC1918A0168Q37234233-2DAF4AD8-BEC4-48C7-9B3A-46EACC1A0A0B
P2860
Gating of cystic fibrosis transmembrane conductance regulator chloride channels by adenosine triphosphate hydrolysis. Quantitative analysis of a cyclic gating scheme
description
1999 nî lūn-bûn
@nan
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
1999年學術文章
@zh
1999年學術文章
@zh-hant
name
Gating of cystic fibrosis tran ...... ysis of a cyclic gating scheme
@ast
Gating of cystic fibrosis tran ...... ysis of a cyclic gating scheme
@en
type
label
Gating of cystic fibrosis tran ...... ysis of a cyclic gating scheme
@ast
Gating of cystic fibrosis tran ...... ysis of a cyclic gating scheme
@en
prefLabel
Gating of cystic fibrosis tran ...... ysis of a cyclic gating scheme
@ast
Gating of cystic fibrosis tran ...... ysis of a cyclic gating scheme
@en
P2093
P2860
P921
P356
P1476
Gating of cystic fibrosis tran ...... ysis of a cyclic gating scheme
@en
P2093
P2860
P304
P356
10.1085/JGP.113.4.541
P577
1999-04-01T00:00:00Z