Effect of ATP concentration on CFTR Cl- channels: a kinetic analysis of channel regulation
about
CFTR gating I: Characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (DeltaR-CFTR).A cluster of negative charges at the amino terminal tail of CFTR regulates ATP-dependent channel gatingImpact of the F508del mutation on ovine CFTR, a Cl- channel with enhanced conductance and ATP-dependent gating.Cystic fibrosis transmembrane conductance regulator gating requires cytosolic electrolytes.Strict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.CFTR channel gating: incremental progress in irreversible steps.Normal gating of CFTR requires ATP binding to both nucleotide-binding domains and hydrolysis at the second nucleotide-binding domain.ADP inhibits function of the ABC transporter cystic fibrosis transmembrane conductance regulator via its adenylate kinase activity.Identification of cystic fibrosis transmembrane conductance regulator channel-lining residues in and flanking the M6 membrane-spanning segment.Phosphate stimulates CFTR Cl- channelsStructural and functional similarities between the nucleotide-binding domains of CFTR and GTP-binding proteinsThe cystic fibrosis transmembrane regulator (CFTR) in the kidney.The block of CFTR by scorpion venom is state-dependentA conditional probability analysis of cystic fibrosis transmembrane conductance regulator gating indicates that ATP has multiple effects during the gating cycle.Mutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gatingInhibition of heterologously expressed cystic fibrosis transmembrane conductance regulator Cl- channels by non-sulphonylurea hypoglycaemic agents.Full-open and closed CFTR channels, with lateral tunnels from the cytoplasm and an alternative position of the F508 region, as revealed by molecular dynamics.Identification of a novel post-hydrolytic state in CFTR gating.Chimeric constructs endow the human CFTR Cl- channel with the gating behavior of murine CFTRThermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle.G551D and G1349D, two CF-associated mutations in the signature sequences of CFTR, exhibit distinct gating defectsAMP-activated protein kinase and nitric oxide regulate the glucose sensitivity of ventromedial hypothalamic glucose-inhibited neurons.Actions of genistein on cystic fibrosis transmembrane conductance regulator channel gating. Evidence for two binding sites with opposite effects.Gating of cystic fibrosis transmembrane conductance regulator chloride channels by adenosine triphosphate hydrolysis. Quantitative analysis of a cyclic gating schemeOn the mechanism of MgATP-dependent gating of CFTR Cl- channelsFunctional roles of nonconserved structural segments in CFTR's NH2-terminal nucleotide binding domain.CFTR: the nucleotide binding folds regulate the accessibility and stability of the activated stateVoltage-dependent gating of the cystic fibrosis transmembrane conductance regulator Cl- channel.Dual effects of ADP and adenylylimidodiphosphate on CFTR channel kinetics show binding to two different nucleotide binding sites.Severed channels probe regulation of gating of cystic fibrosis transmembrane conductance regulator by its cytoplasmic domainsCFTR: covalent modification of cysteine-substituted channels expressed in Xenopus oocytes shows that activation is due to the opening of channels resident in the plasma membraneDistinct Mg(2+)-dependent steps rate limit opening and closing of a single CFTR Cl(-) channel.Prolonged nonhydrolytic interaction of nucleotide with CFTR's NH2-terminal nucleotide binding domain and its role in channel gating.Dynamics intrinsic to cystic fibrosis transmembrane conductance regulator function and stabilityVx-770 potentiates CFTR function by promoting decoupling between the gating cycle and ATP hydrolysis cycle.A mutation in CFTR modifies the effects of the adenylate kinase inhibitor Ap5A on channel gating.CLC-0 and CFTR: chloride channels evolved from transporters.State-dependent modulation of CFTR gating by pyrophosphate.Acute inhibition of the cystic fibrosis transmembrane conductance regulator (CFTR) Cl- channel by thyroid hormones involves multiple mechanisms.Regulation of CFTR Cl- channel gating by ATP binding and hydrolysis.
P2860
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P2860
Effect of ATP concentration on CFTR Cl- channels: a kinetic analysis of channel regulation
description
1994 nî lūn-bûn
@nan
1994 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի մայիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Effect of ATP concentration on ...... analysis of channel regulation
@ast
Effect of ATP concentration on ...... analysis of channel regulation
@en
Effect of ATP concentration on ...... analysis of channel regulation
@nl
type
label
Effect of ATP concentration on ...... analysis of channel regulation
@ast
Effect of ATP concentration on ...... analysis of channel regulation
@en
Effect of ATP concentration on ...... analysis of channel regulation
@nl
prefLabel
Effect of ATP concentration on ...... analysis of channel regulation
@ast
Effect of ATP concentration on ...... analysis of channel regulation
@en
Effect of ATP concentration on ...... analysis of channel regulation
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P2093
P2860
P1433
P1476
Effect of ATP concentration on ...... analysis of channel regulation
@en
P2093
P2860
P304
P356
10.1016/S0006-3495(94)80930-0
P407
P577
1994-05-01T00:00:00Z