Nicotinic receptor fourth transmembrane domain: hydrogen bonding by conserved threonine contributes to channel gating kinetics.
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The local anaesthetics proadifen and adiphenine inhibit nicotinic receptors by different molecular mechanismsThe dissociation of acetylcholine from open nicotinic receptor channelsThe quality of maximum likelihood estimates of ion channel rate constants.Subunit-selective contribution to channel gating of the M4 domain of the nicotinic receptorHomology modeling and molecular dynamics simulations of transmembrane domain structure of human neuronal nicotinic acetylcholine receptorPlasticity of acetylcholine receptor gating motions via rate-energy relationships.A Cys-loop mutation in the Caenorhabditis elegans nicotinic receptor subunit UNC-63 impairs but does not abolish channel functionMapping heat exchange in an allosteric proteinLinking of Glycine Receptor Transmembrane Segments Three and Four Allows Assignment of Intrasubunit-Facing Residues.Aromaticity at the water-hydrocarbon core interface of the membrane: consequences on the nicotinic acetylcholine receptor.Role of pairwise interactions between M1 and M2 domains of the nicotinic receptor in channel gatingTryptophan fluorescence reveals conformational changes in the acetylcholine binding protein.Novel beta subunit mutation causes a slow-channel syndrome by enhancing activation and decreasing the rate of agonist dissociationAcetylcholine receptor gating at extracellular transmembrane domain interface: the cys-loop and M2-M3 linker.Role of the Fourth Transmembrane α Helix in the Allosteric Modulation of Pentameric Ligand-Gated Ion Channels.Structure-guided drug design: conferring selectivity among neuronal nicotinic receptor and acetylcholine-binding protein subtypes.The interface between extracellular and transmembrane domains of homomeric Cys-loop receptors governs open-channel lifetime and rate of desensitization.Number and locations of agonist binding sites required to activate homomeric Cys-loop receptorsGlutamine 57 at the complementary binding site face is a key determinant of morantel selectivity for {alpha}7 nicotinic receptors.Interaction of bupropion with muscle-type nicotinic acetylcholine receptors in different conformational states.Stoichiometry for activation of neuronal α7 nicotinic receptors.The structural basis of function in Cys-loop receptors.Novel alpha7-like nicotinic acetylcholine receptor subunits in the nematode Caenorhabditis elegans.Nicotinic acetylcholine receptors at the single-channel level.The M4 Transmembrane α-Helix Contributes Differently to Both the Maturation and Function of Two Prokaryotic Pentameric Ligand-gated Ion Channels.Properties of the human muscle nicotinic receptor, and of the slow-channel myasthenic syndrome mutant epsilonL221F, inferred from maximum likelihood fits.Intramembrane aromatic interactions influence the lipid sensitivities of pentameric ligand-gated ion channels.Pentameric ligand-gated ion channels exhibit distinct transmembrane domain archetypes for folding/expression and function.Tryptophan scanning mutagenesis reveals distortions in the helical structure of the δM4 transmembrane domain of the Torpedo californica nicotinic acetylcholine receptor.Tryptophan-scanning mutagenesis in the alphaM3 transmembrane domain of the muscle-type acetylcholine receptor. A spring model revealed.Molecular basis of the differential sensitivity of nematode and mammalian muscle to the anthelmintic agent levamisole.The M4 transmembrane segment contributes to agonist efficacy differences between alpha1 and alpha3 glycine receptors.Modulation of nicotinic acetylcholine receptor conformational state by free fatty acids and steroids.Role of the Cys Loop and Transmembrane Domain in the Allosteric Modulation of α4β2 Nicotinic Acetylcholine Receptors.
P2860
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P2860
Nicotinic receptor fourth transmembrane domain: hydrogen bonding by conserved threonine contributes to channel gating kinetics.
description
2000 nî lūn-bûn
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2000年の論文
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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2000年学术文章
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name
Nicotinic receptor fourth tran ...... es to channel gating kinetics.
@ast
Nicotinic receptor fourth tran ...... es to channel gating kinetics.
@en
type
label
Nicotinic receptor fourth tran ...... es to channel gating kinetics.
@ast
Nicotinic receptor fourth tran ...... es to channel gating kinetics.
@en
prefLabel
Nicotinic receptor fourth tran ...... es to channel gating kinetics.
@ast
Nicotinic receptor fourth tran ...... es to channel gating kinetics.
@en
P2093
P2860
P356
P1476
Nicotinic receptor fourth tran ...... es to channel gating kinetics.
@en
P2093
P2860
P304
P356
10.1085/JGP.115.5.663
P577
2000-05-01T00:00:00Z