Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of residues that determine curare selectivity.
about
A structural and mutagenic blueprint for molecular recognition of strychnine and d-tubocurarine by different cys-loop receptorsCongenital myasthenic syndrome caused by prolonged acetylcholine receptor channel openings due to a mutation in the M2 domain of the epsilon subunitEpibatidine activates muscle acetylcholine receptors with unique site selectivity.End-plate acetylcholine receptor: structure, mechanism, pharmacology, and diseaseIdentification of critical residues in loop E in the 5-HT3ASR binding siteProbing the Structure of the Nicotinic Acetylcholine Receptor with 4-Benzoylbenzoylcholine, a Novel Photoaffinity Competitive AntagonistNuclear magnetic resonance solution conformation of alpha-conotoxin AuIB, an alpha(3)beta(4) subtype-selective neuronal nicotinic acetylcholine receptor antagonistStructure-Function Elucidation of a New -Conotoxin, Lo1a, from Conus longurionisOrganisation of the murine 5-HT3 receptor gene and assignment to human chromosome 11Mapping the agonist binding site of the nicotinic acetylcholine receptor. Orientation requirements for activation by covalent agonistAcetylcholine receptor channels activated by a single agonist molecule.Models of the extracellular domain of the nicotinic receptors and of agonist- and Ca2+-binding sites.Inorganic, monovalent cations compete with agonists for the transmitter binding site of nicotinic acetylcholine receptorsPhotolabeling reveals the proximity of the alpha-neurotoxin binding site to the M2 helix of the ion channel in the nicotinic acetylcholine receptor.Activation kinetics of recombinant mouse nicotinic acetylcholine receptors: mutations of alpha-subunit tyrosine 190 affect both binding and gating.Subunit-selective contribution to channel gating of the M4 domain of the nicotinic receptorCrystal structure of acetylcholine-binding protein from Bulinus truncatus reveals the conserved structural scaffold and sites of variation in nicotinic acetylcholine receptors.Free-energy landscapes of ion-channel gating are malleable: changes in the number of bound ligands are accompanied by changes in the location of the transition state in acetylcholine-receptor channelsRoles of amino acids and subunits in determining the inhibition of nicotinic acetylcholine receptors by competitive antagonists.Curariform antagonists bind in different orientations to acetylcholine-binding proteinSingle-channel and structural foundations of neuronal α7 acetylcholine receptor potentiation.High Throughput Random Mutagenesis and Single Molecule Real Time Sequencing of the Muscle Nicotinic Acetylcholine ReceptorMembrane tethering enables an extracellular domain of the acetylcholine receptor alpha subunit to form a heterodimeric ligand-binding site.Estimating binding affinities of the nicotinic receptor for low-efficacy ligands using mixtures of agonists and two-dimensional concentration-response relationshipsBlock of muscle nicotinic receptors by choline suggests that the activation and desensitization gates act as distinct molecular entities.Regions of beta 2 and beta 4 responsible for differences between the steady state dose-response relationships of the alpha 3 beta 2 and alpha 3 beta 4 neuronal nicotinic receptors.Nicotinic receptor fourth transmembrane domain: hydrogen bonding by conserved threonine contributes to channel gating kinetics.Kinetic, mechanistic, and structural aspects of unliganded gating of acetylcholine receptor channels: a single-channel study of second transmembrane segment 12' mutants.The extracellular linker of muscle acetylcholine receptor channels is a gating control element.Initial coupling of binding to gating mediated by conserved residues in the muscle nicotinic receptorStoichiometry for drug potentiation of a pentameric ion channelSynergy between pairs of competitive antagonists at adult human muscle acetylcholine receptors.Preliminary results of the in vivo and in vitro characterization of a tentacle venom fraction from the jellyfish Aurelia aurita.Regulation of nicotinic receptor expression by the ubiquitin-proteasome systemMolecular determinants conferring alpha-toxin resistance in recombinant DNA-derived acetylcholine receptors.α4β2 Nicotinic Acetylcholine Receptors: RELATIONSHIPS BETWEEN SUBUNIT STOICHIOMETRY AND FUNCTION AT THE SINGLE CHANNEL LEVEL.A mutational analysis of the acetylcholine receptor channel transmitter binding site.Curariform antagonists bind in different orientations to the nicotinic receptor ligand binding domain.Lysine scanning mutagenesis delineates structural model of the nicotinic receptor ligand binding domain.Structural elements near the C-terminus are responsible for changes in nicotinic receptor gating kinetics following patch excision.
P2860
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P2860
Molecular dissection of subunit interfaces in the acetylcholine receptor: identification of residues that determine curare selectivity.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
1993年论文
@zh
1993年论文
@zh-cn
name
Molecular dissection of subuni ...... determine curare selectivity.
@ast
Molecular dissection of subuni ...... determine curare selectivity.
@en
type
label
Molecular dissection of subuni ...... determine curare selectivity.
@ast
Molecular dissection of subuni ...... determine curare selectivity.
@en
prefLabel
Molecular dissection of subuni ...... determine curare selectivity.
@ast
Molecular dissection of subuni ...... determine curare selectivity.
@en
P2860
P356
P1476
Molecular dissection of subuni ...... determine curare selectivity.
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.20.9436
P407
P577
1993-10-01T00:00:00Z