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KCNE1 and KCNE3 stabilize and/or slow voltage sensing S4 segment of KCNQ1 channelTwo separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channelsP-loop residues critical for selectivity in K channels fail to confer selectivity to rabbit HCN4 channels.Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment.Molecular mechanism underlying phosphatidylinositol 4,5-bisphosphate-induced inhibition of SpIH channels.Insights into the mechanism of pore opening of acid-sensing ion channel 1a.cAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel.A conformation change in the extracellular domain that accompanies desensitization of acid-sensing ion channel (ASIC) 3.Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels.Kinetic relationship between the voltage sensor and the activation gate in spHCN channelsKCNE peptides differently affect voltage sensor equilibrium and equilibration rates in KCNQ1 K+ channelsChanges in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels.Hysteresis in the voltage dependence of HCN channels: conversion between two modes affects pacemaker propertiesIntracellular Mg2+ is a voltage-dependent pore blocker of HCN channels.Probing S4 and S5 segment proximity in mammalian hyperpolarization-activated HCN channels by disulfide bridging and Cd2+ coordinationBiochemical and structural analysis of the hyperpolarization-activated K(+) channel MVPCytoplasmic domains and voltage-dependent potassium channel gating.The influence of lipids on voltage-gated ion channels.Emerging approaches to probing ion channel structure and function.HCN Channel C-Terminal Region Speeds Activation Rates Independently of Autoinhibition.Functional characterization of Ih-channel splice variants from Apis mellifera.Structural elements of instantaneous and slow gating in hyperpolarization-activated cyclic nucleotide-gated channels.Ion binding in the open HCN pacemaker channel pore: fast mechanisms to shape "slow" channels.State-dependent cAMP binding to functioning HCN channels studied by patch-clamp fluorometry.The intrinsically liganded cyclic nucleotide-binding homology domain promotes KCNH channel activation.Ethanol enhances human hyperpolarization-activated cyclic nucleotide-gated currents.Alanine scanning of the S6 segment reveals a unique and cAMP-sensitive association between the pore and voltage-dependent opening in HCN channels.Niflumic acid alters gating of HCN2 pacemaker channels by interaction with the outer region of S4 voltage sensing domains.How S4 segments move charge. Let me count the ways.Structural insights into the mechanisms of CNBD channel function.Tryptophan-scanning mutagenesis in the S1 domain of mammalian HCN channel reveals residues critical for voltage-gated activation.
P2860
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P2860
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh
2003年學術文章
@zh-hant
name
S4 movement in a mammalian HCN channel.
@ast
S4 movement in a mammalian HCN channel.
@en
type
label
S4 movement in a mammalian HCN channel.
@ast
S4 movement in a mammalian HCN channel.
@en
prefLabel
S4 movement in a mammalian HCN channel.
@ast
S4 movement in a mammalian HCN channel.
@en
P2093
P2860
P356
P1476
S4 movement in a mammalian HCN channel.
@en
P2093
H Peter Larsson
Shilpi Pandey
Sriharsha Vemana
P2860
P356
10.1085/JGP.200308916
P577
2003-12-15T00:00:00Z