Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels.
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Structural Basis for the cAMP-dependent Gating in the Human HCN4 ChannelKCNE1 and KCNE3 stabilize and/or slow voltage sensing S4 segment of KCNQ1 channelS3b amino acid residues do not shuttle across the bilayer in voltage-dependent Shaker K+ channels.P-loop residues critical for selectivity in K channels fail to confer selectivity to rabbit HCN4 channels.Reversed voltage-dependent gating of a bacterial sodium channel with proline substitutions in the S6 transmembrane segment.Coupled motions between pore and voltage-sensor domains: a model for Shaker B, a voltage-gated potassium channelEnvironment of the gating charges in the Kv1.2 Shaker potassium channelcAMP control of HCN2 channel Mg2+ block reveals loose coupling between the cyclic nucleotide-gating ring and the pore.Inner activation gate in S6 contributes to the state-dependent binding of cAMP in full-length HCN2 channel.Sodium channel inactivation: molecular determinants and modulation.Molecular template for a voltage sensor in a novel K+ channel. I. Identification and functional characterization of KvLm, a voltage-gated K+ channel from Listeria monocytogenes.Reversal of HCN channel voltage dependence via bridging of the S4-S5 linker and Post-S6.Voltage sensor movement and cAMP binding allosterically regulate an inherently voltage-independent closed-open transition in HCN channels.Kinetic relationship between the voltage sensor and the activation gate in spHCN channelsCharge movement in gating-locked HCN channels reveals weak coupling of voltage sensors and gate.S4 movement in a mammalian HCN channel.Gating charges in the activation and inactivation processes of the HERG channelIntracellular Mg2+ is a voltage-dependent pore blocker of HCN channels.State-dependent accessibility of the P-S6 linker of pacemaker (HCN) channels supports a dynamic pore-to-gate coupling model.Probing S4 and S5 segment proximity in mammalian hyperpolarization-activated HCN channels by disulfide bridging and Cd2+ coordinationHCN Channel C-Terminal Region Speeds Activation Rates Independently of Autoinhibition.Functional characterization of Ih-channel splice variants from Apis mellifera.Structural elements of instantaneous and slow gating in hyperpolarization-activated cyclic nucleotide-gated channels.Molecular mechanism of voltage sensor movements in a potassium channel.Normal-mode-analysis-guided investigation of crucial intersubunit contacts in the cAMP-dependent gating in HCN channels.Ion binding in the open HCN pacemaker channel pore: fast mechanisms to shape "slow" channels.State-dependent cAMP binding to functioning HCN channels studied by patch-clamp fluorometry.Interaction of diverse voltage sensor homologs with lipid bilayers revealed by self-assembly simulationsAlanine scanning of the S6 segment reveals a unique and cAMP-sensitive association between the pore and voltage-dependent opening in HCN channels.Voltage-sensor transitions of the inward-rectifying K+ channel KAT1 indicate a latching mechanism biased by hydration within the voltage sensor.Dual Regulation of Voltage-Sensitive Ion Channels by PIP(2).Niflumic acid alters gating of HCN2 pacemaker channels by interaction with the outer region of S4 voltage sensing domains.How S4 segments move charge. Let me count the ways.Tryptophan scanning mutagenesis of the HERG K+ channel: the S4 domain is loosely packed and likely to be lipid exposed.Structural and functional determinants in the S5-P region of HCN-encoded pacemaker channels revealed by cysteine-scanning substitutions.Three-dimensional analysis, modeling, and simulation of the effect of static magnetic fields on neurons.Tryptophan-scanning mutagenesis in the S1 domain of mammalian HCN channel reveals residues critical for voltage-gated activation.Molecular compatibility of the channel gate and the N terminus of S5 segment for voltage-gated channel activity
P2860
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P2860
Changes in local S4 environment provide a voltage-sensing mechanism for mammalian hyperpolarization-activated HCN channels.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
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2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
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2003年學術文章
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name
Changes in local S4 environmen ...... zation-activated HCN channels.
@ast
Changes in local S4 environmen ...... zation-activated HCN channels.
@en
type
label
Changes in local S4 environmen ...... zation-activated HCN channels.
@ast
Changes in local S4 environmen ...... zation-activated HCN channels.
@en
prefLabel
Changes in local S4 environmen ...... zation-activated HCN channels.
@ast
Changes in local S4 environmen ...... zation-activated HCN channels.
@en
P2093
P2860
P356
P1476
Changes in local S4 environmen ...... zation-activated HCN channels.
@en
P2093
Damian C Bell
John H Riley
Renee C Saenger
Steven A Siegelbaum
P2860
P356
10.1085/JGP.200308918
P577
2003-12-15T00:00:00Z