Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA. - Wikidata - awgldk - TriplyDB

Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.

Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.

http://www.wikidata.org/entity/Q36412598

about

The ABC protein turned chloride channel whose failure causes cystic fibrosis CFTR gating I: Characterization of the ATP-dependent gating of a phosphorylation-independent CFTR channel (DeltaR-CFTR).Cystic fibrosis transmembrane conductance regulator modulators in cystic fibrosis: current perspectives State-dependent regulation of cystic fibrosis transmembrane conductance regulator (CFTR) gating by a high affinity Fe3+ bridge between the regulatory domain and cytoplasmic loop 3.The inhibition mechanism of non-phosphorylated Ser768 in the regulatory domain of cystic fibrosis transmembrane conductance regulator Detection of phospho-sites generated by protein kinase CK2 in CFTR: mechanistic aspects of Thr1471 phosphorylation Phosphorylation-dependent 14-3-3 protein interactions regulate CFTR biogenesis Identification of a novel post-hydrolytic state in CFTR gating.Regulation of the cystic fibrosis transmembrane conductance regulator anion channel by tyrosine phosphorylation.Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation.Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle.Insight in eukaryotic ABC transporter function by mutation analysis.Regulation of activation and processing of the cystic fibrosis transmembrane conductance regulator (CFTR) by a complex electrostatic interaction between the regulatory domain and cytoplasmic loop 3.The CFTR ion channel: gating, regulation, and anion permeation How Phosphorylation and ATPase Activity Regulate Anion Flux though the Cystic Fibrosis Transmembrane Conductance Regulator (CFTR).CLC-0 and CFTR: chloride channels evolved from transporters.AMP-activated protein kinase phosphorylation of the R domain inhibits PKA stimulation of CFTR.CFTR regulatory region interacts with NBD1 predominantly via multiple transient helices Synergy of cAMP and calcium signaling pathways in CFTR regulation.Regulation of ABC transporter function via phosphorylation by protein kinases.Cystic fibrosis transmembrane conductance regulator (ABCC7) structure Structural changes of CFTR R region upon phosphorylation: a plastic platform for intramolecular and intermolecular interactions.In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer.Potential sites of CFTR activation by tyrosine kinases.Trafficking and function of the cystic fibrosis transmembrane conductance regulator: a complex network of posttranslational modifications.The major cystic fibrosis causing mutation exhibits defective propensity for phosphorylation.Current insights into the role of PKA phosphorylation in CFTR channel activity and the pharmacological rescue of cystic fibrosis disease-causing mutants.Mechanistic insight into control of CFTR by AMPK.The Walker B motif of the second nucleotide-binding domain (NBD2) of CFTR plays a key role in ATPase activity by the NBD1-NBD2 heterodimer.Negative regulation of the yeast ABC transporter Ycf1p by phosphorylation within its N-terminal extension.Computational studies reveal phosphorylation-dependent changes in the unstructured R domain of CFTR.Protein kinase A regulates C-terminally truncated CaV 1.2 in Xenopus oocytes: roles of N- and C-termini of the α1C subunit.Structural mechanisms of CFTR function and dysfunction.

P2860

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P2860

Preferential phosphorylation of R-domain Serine 768 dampens activation of CFTR channels by PKA.

http://www.wikidata.org/entity/Q36412598

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2005 nî lūn-bûn

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2005年の論文

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年学术文章

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2005年學術文章

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2005年學術文章

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2005年學術文章

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Preferential phosphorylation o ...... ation of CFTR channels by PKA.

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Preferential phosphorylation o ...... ation of CFTR channels by PKA.

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Preferential phosphorylation o ...... ation of CFTR channels by PKA.

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Preferential phosphorylation o ...... ation of CFTR channels by PKA.

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Preferential phosphorylation o ...... ation of CFTR channels by PKA.

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The Journal of General Physiology

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Preferential phosphorylation o ...... ation of CFTR channels by PKA.

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P2093

Andrew N Krutchinsky

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Benjamin B Angel

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Brian T Chait

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Cristina Cenciarelli

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David C Gadsby

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Derek T McLachlin

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Donna Seto-Young

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Jun Qin

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Kim W Chan

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P2860

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle

Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator

Phosphopeptide mapping and phosphoamino acid analysis by two-dimensional separation on thin-layer cellulose plates

Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA

Structure and function of the CFTR chloride channel

Phosphorylation of the cystic fibrosis transmembrane conductance regulator

Rapidly switchable matrix-assisted laser desorption/ionization and electrospray quadrupole-time-of-flight mass spectrometry for protein identification.

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171-186

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10.1085/JGP.200409076

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2

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125

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László Csanády

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2005-01-18T00:00:00Z

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8074720

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15657296

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phosphorylation

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2217491

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