In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer. - Wikidata - awgldk - TriplyDB

In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer.

In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer.

http://www.wikidata.org/entity/Q38774272

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Biochemical Basis of the Interaction between Cystic Fibrosis Transmembrane Conductance Regulator and Immunoglobulin-like Repeats of Filamin Allosteric coupling between the intracellular coupling helix 4 and regulatory sites of the first nucleotide-binding domain of CFTR Curcumin and genistein: the combined effects on disease-associated CFTR mutants and their clinical implications Development of CFTR Structure ATP and AMP mutually influence their interaction with the ATP-binding cassette (ABC) adenylate kinase cystic fibrosis transmembrane conductance regulator (CFTR) at separate binding sites.Small molecule correctors of F508del-CFTR discovered by structure-based virtual screening ATP-independent CFTR channel gating and allosteric modulation by phosphorylation.Directed evolution of P-glycoprotein cysteines reveals site-specific, non-conservative substitutions that preserve multidrug resistance.Stable ATP binding mediated by a partial NBD dimer of the CFTR chloride channel Potentiation of disease-associated cystic fibrosis transmembrane conductance regulator mutants by hydrolyzable ATP analogs.Contribution of casein kinase 2 and spleen tyrosine kinase to CFTR trafficking and protein kinase A-induced activity.Dual roles of the sixth transmembrane segment of the CFTR chloride channel in gating and permeation.Intragenic suppressing mutations correct the folding and intracellular traffic of misfolded mutants of Yor1p, a eukaryotic drug transporter.State-dependent regulation of cystic fibrosis transmembrane conductance regulator (CFTR) gating by a high affinity Fe3+ bridge between the regulatory domain and cytoplasmic loop 3.An electrostatic interaction at the tetrahelix bundle promotes phosphorylation-dependent cystic fibrosis transmembrane conductance regulator (CFTR) channel opening.The inhibition mechanism of non-phosphorylated Ser768 in the regulatory domain of cystic fibrosis transmembrane conductance regulator Mutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gating Cysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels.Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators.Structural basis for the channel function of a degraded ABC transporter, CFTR (ABCC7).Cystic fibrosis transmembrane conductance regulator: a molecular model defines the architecture of the anion conduction path and locates a "bottleneck" in the pore.Identification of a novel post-hydrolytic state in CFTR gating.Regulation of the cystic fibrosis transmembrane conductance regulator anion channel by tyrosine phosphorylation.Benzopyrimido-pyrrolo-oxazine-dione (R)-BPO-27 Inhibits CFTR Chloride Channel Gating by Competition with ATP Murine and human CFTR exhibit different sensitivities to CFTR potentiators.Molecular modelling and molecular dynamics of CFTR.Nonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation.Deletion of Phenylalanine 508 in the First Nucleotide-binding Domain of the Cystic Fibrosis Transmembrane Conductance Regulator Increases Conformational Exchange and Inhibits Dimerization.Transmembrane helical interactions in the CFTR channel pore.Locating a plausible binding site for an open-channel blocker, GlyH-101, in the pore of the cystic fibrosis transmembrane conductance regulator.The CFTR ion channel: gating, regulation, and anion permeation Long-range coupling between the extracellular gates and the intracellular ATP binding domains of multidrug resistance protein pumps and cystic fibrosis transmembrane conductance regulator channels Positioning of extracellular loop 1 affects pore gating of the cystic fibrosis transmembrane conductance regulator Structure and function of ABC transporters.Spatial positioning of CFTR's pore-lining residues affirms an asymmetrical contribution of transmembrane segments to the anion permeation pathway Two salt bridges differentially contribute to the maintenance of cystic fibrosis transmembrane conductance regulator (CFTR) channel function.RACK1 interacts with filamin-A to regulate plasma membrane levels of the cystic fibrosis transmembrane conductance regulator.Nonequilibrium gating of CFTR on an equilibrium theme.CLC-0 and CFTR: chloride channels evolved from transporters.State-dependent modulation of CFTR gating by pyrophosphate.

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P2860

In vivo phosphorylation of CFTR promotes formation of a nucleotide-binding domain heterodimer.

http://www.wikidata.org/entity/Q38774272

description

2006 nî lūn-bûn

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2006年の論文

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2006年論文

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2006年論文

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name

In vivo phosphorylation of CFT ...... de-binding domain heterodimer.

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type

label

In vivo phosphorylation of CFT ...... de-binding domain heterodimer.

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prefLabel

In vivo phosphorylation of CFT ...... de-binding domain heterodimer.

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SJ.EMBOJ.7601373

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The EMBO Journal

P1476

In vivo phosphorylation of CFT ...... de-binding domain heterodimer.

@en

P2093

David C Gadsby

http://www.w3.org/2001/XMLSchema#string

Dennis M White

http://www.w3.org/2001/XMLSchema#string

Gal Altberg

http://www.w3.org/2001/XMLSchema#string

Martin Mense

http://www.w3.org/2001/XMLSchema#string

P2860

H662 is the linchpin of ATP hydrolysis in the nucleotide-binding domain of the ABC transporter HlyB

Vanadate-catalyzed photocleavage of the signature motif of an ATP-binding cassette (ABC) transporter.

ATP binding to the motor domain from an ABC transporter drives formation of a nucleotide sandwich dimer

Structural biology of Rad50 ATPase: ATP-driven conformational control in DNA double-strand break repair and the ABC-ATPase superfamily

The crystal structure of the MJ0796 ATP-binding cassette. Implications for the structural consequences of ATP hydrolysis in the active site of an ABC transporter

Crystal structures of the MJ1267 ATP binding cassette reveal an induced-fit effect at the ATPase active site of an ABC transporter

The E. coli BtuCD structure: a framework for ABC transporter architecture and mechanism

Crystal structures of the ATPase subunit of the glucose ABC transporter from Sulfolobus solfataricus: nucleotide-free and nucleotide-bound conformations

A tweezers-like motion of the ATP-binding cassette dimer in an ABC transport cycle

Structure of nucleotide-binding domain 1 of the cystic fibrosis transmembrane conductance regulator

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10.1038/SJ.EMBOJ.7601373

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20

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25

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17036051

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phosphorylation

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1618097

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