Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle.
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Allosteric coupling between the intracellular coupling helix 4 and regulatory sites of the first nucleotide-binding domain of CFTRAn outer membrane protein undergoes enthalpy- and entropy-driven transitionsStrict coupling between CFTR's catalytic cycle and gating of its Cl- ion pore revealed by distributions of open channel burst durations.Potentiation of disease-associated cystic fibrosis transmembrane conductance regulator mutants by hydrolyzable ATP analogs.Structure-activity analysis of a CFTR channel potentiator: Distinct molecular parts underlie dual gating effects.Modeling the conformational changes underlying channel opening in CFTRMutant cycles at CFTR's non-canonical ATP-binding site support little interface separation during gatingCysteine accessibility probes timing and extent of NBD separation along the dimer interface in gating CFTR channels.Regulatory domain phosphorylation to distinguish the mechanistic basis underlying acute CFTR modulators.Identification of a novel post-hydrolytic state in CFTR gating.Thermal instability of ΔF508 cystic fibrosis transmembrane conductance regulator (CFTR) channel function: protection by single suppressor mutations and inhibiting channel activityNonintegral stoichiometry in CFTR gating revealed by a pore-lining mutation.The CFTR ion channel: gating, regulation, and anion permeationConverting nonhydrolyzable nucleotides to strong cystic fibrosis transmembrane conductance regulator (CFTR) agonists by gain of function (GOF) mutationsNonequilibrium gating of CFTR on an equilibrium theme.CLC-0 and CFTR: chloride channels evolved from transporters.Cystic fibrosis as a bowel cancer syndrome and the potential role of CK2.Application of rate-equilibrium free energy relationship analysis to nonequilibrium ion channel gating mechanismsGating of the CFTR Cl- channel by ATP-driven nucleotide-binding domain dimerisation.Exploring conformational equilibria of a heterodimeric ABC transporter.Catalyst-like modulation of transition states for CFTR channel opening and closing: new stimulation strategy exploits nonequilibrium gating.A unified view of cystic fibrosis transmembrane conductance regulator (CFTR) gating: combining the allosterism of a ligand-gated channel with the enzymatic activity of an ATP-binding cassette (ABC) transporterCystic fibrosis transmembrane conductance regulator (ABCC7) structureThe gating of the CFTR channel.Cystic fibrosis transmembrane conductance regulator: temperature-dependent cysteine reactivity suggests different stable conformers of the conduction pathwayChanges in accessibility of cytoplasmic substances to the pore associated with activation of the cystic fibrosis transmembrane conductance regulator chloride channel.The most common cystic fibrosis-associated mutation destabilizes the dimeric state of the nucleotide-binding domains of CFTR.Chaperones rescue the energetic landscape of mutant CFTR at single molecule and in cell.Asymmetry of movements in CFTR's two ATP sites during pore opening serves their distinct functions.Involvement of F1296 and N1303 of CFTR in induced-fit conformational change in response to ATP binding at NBD2Conformational changes in a pore-lining helix coupled to cystic fibrosis transmembrane conductance regulator channel gating.NM23 proteins: innocent bystanders or local energy boosters for CFTR?Relationship between nucleotide binding and ion channel gating in cystic fibrosis transmembrane conductance regulator.
P2860
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P2860
Thermodynamics of CFTR channel gating: a spreading conformational change initiates an irreversible gating cycle.
description
2006 nî lūn-bûn
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2006年の論文
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2006年学术文章
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2006年学术文章
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name
Thermodynamics of CFTR channel ...... an irreversible gating cycle.
@ast
Thermodynamics of CFTR channel ...... an irreversible gating cycle.
@en
type
label
Thermodynamics of CFTR channel ...... an irreversible gating cycle.
@ast
Thermodynamics of CFTR channel ...... an irreversible gating cycle.
@en
prefLabel
Thermodynamics of CFTR channel ...... an irreversible gating cycle.
@ast
Thermodynamics of CFTR channel ...... an irreversible gating cycle.
@en
P2860
P356
P1476
Thermodynamics of CFTR channel ...... an irreversible gating cycle.
@en
P2093
David C Gadsby
P2860
P304
P356
10.1085/JGP.200609558
P577
2006-10-16T00:00:00Z