The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding.
about
Molecular basis of Kir6.2 mutations associated with neonatal diabetes or neonatal diabetes plus neurological featuresNoble gas xenon is a novel adenosine triphosphate-sensitive potassium channel openerHow ATP inhibits the open K(ATP) channelHyperinsulinemic Hypoglycemia - The Molecular MechanismsPhosphoinositide regulation of inward rectifier potassium (Kir) channelsA novel KCNJ11 mutation associated with congenital hyperinsulinism reduces the intrinsic open probability of beta-cell ATP-sensitive potassium channelsThe carboxyl termini of K(ATP) channels bind nucleotidesATP interaction with the open state of the K(ATP) channel.Activation of ATP-sensitive K(+) channels by epoxyeicosatrienoic acids in rat cardiac ventricular myocytesNovel nucleotide-binding sites in ATP-sensitive potassium channels formed at gating interfaces.ATP modulation of ATP-sensitive potassium channel ATP sensitivity varies with the type of SUR subunit.Phosphatidylinositol-4,5-bisphosphate (PIP(2)) stabilizes the open pore conformation of the Kv11.1 (hERG) channelMolecular basis for Kir6.2 channel inhibition by adenine nucleotides.A ring of negative charges in the intracellular vestibule of Kir2.1 channel modulates K+ permeation.Congenital hyperinsulinism and glucose hypersensitivity in homozygous and heterozygous carriers of Kir6.2 (KCNJ11) mutation V290M mutation: K(ATP) channel inactivation mechanism and clinical management.Defective trafficking and function of KATP channels caused by a sulfonylurea receptor 1 mutation associated with persistent hyperinsulinemic hypoglycemia of infancy.Statistical evaluation of ion-channel gating models based on distributions of log-likelihood ratios.N-terminal transmembrane domain of SUR1 controls gating of Kir6.2 by modulating channel sensitivity to PIP2Functional characterization of a novel KCNJ11 in frame mutation-deletion associated with infancy-onset diabetes and a mild form of intermediate DEND: a battle between K(ATP) gain of channel activity and loss of channel expression.Diabetes and insulin secretion: whither KATP?Flexibility of the Kir6.2 inward rectifier K(+) channel poreN-terminal transmembrane domain of the SUR controls trafficking and gating of Kir6 channel subunits.Gating mechanism of KATP channels: function fits form.Measuring and evaluating the role of ATP-sensitive K+ channels in cardiac muscle.A Conserved Residue Cluster That Governs Kinetics of ATP-dependent Gating of Kir6.2 Potassium ChannelsAdjacent mutations in the gating loop of Kir6.2 produce neonatal diabetes and hyperinsulinism.Opposite Effects of the S4-S5 Linker and PIP(2) on Voltage-Gated Channel Function: KCNQ1/KCNE1 and Other Channels.Engineered interaction between SUR1 and Kir6.2 that enhances ATP sensitivity in KATP channels.Phosphatidylinositol-4,5-bisphosphate, PIP2, controls KCNQ1/KCNE1 voltage-gated potassium channels: a functional homology between voltage-gated and inward rectifier K+ channels.A cysteine scan of the inner vestibule of cyclic nucleotide-gated channels reveals architecture and rearrangement of the pore.Regulation of Kir channels by intracellular pH and extracellular K(+): mechanisms of coupling.KATP Channels in the Cardiovascular System.Structural determinants of PIP(2) regulation of inward rectifier K(ATP) channels.The role of NH2-terminal positive charges in the activity of inward rectifier KATP channelsStabilization of the activity of ATP-sensitive potassium channels by ion pairs formed between adjacent Kir6.2 subunits.Hydrolyzable ATP and PIP(2) modulate the small-conductance K+ channel in apical membranes of rat cortical-collecting duct (CCD).Ligand-induced closure of inward rectifier Kir6.2 channels traps spermine in the poreRegulation of cloned ATP-sensitive K channels by phosphorylation, MgADP, and phosphatidylinositol bisphosphate (PIP(2)): a study of channel rundown and reactivationRegulation of cloned ATP-sensitive K channels by adenine nucleotides and sulfonylureas: interactions between SUR1 and positively charged domains on Kir6.2.Permeant ion-dependent changes in gating of Kir2.1 inward rectifier potassium channels.
P2860
Q24320031-95F86DBA-9237-41FB-B432-DA898BA28EFAQ24615367-7F79DF39-F3B5-4E00-A507-1039E7078C0EQ24648821-613B62AE-168E-44E3-A67A-9107BBBD063CQ26749617-76D2D2B3-8E61-4FCC-ABC6-A43F8D74A038Q26865501-8E3544D5-5F34-4E7B-BCF1-03B1EE1FEDCBQ27863904-38E313FD-F8D5-43C4-912B-ABC5E6FD63D2Q28214861-30C16558-B8AB-4457-98DF-F91C76AC4C36Q28346280-CEC64D11-A239-4390-A90D-44D684448D58Q28366511-9FC82914-16C9-4296-BABF-CDF7823C5E10Q28564824-2CF555DE-DEB9-406E-9955-3176913D9288Q31685657-945D857C-B8DC-4477-9FF3-0D08D5920D9BQ34062260-94F9A833-F750-4A67-889C-6C67402FB9C5Q34180112-5F2F1F7B-FFF5-4F34-B571-5D753BC1A73FQ34188472-ADDA7DBC-46E4-4836-BE88-7379257F3BEFQ34448663-336C4F1B-B3FF-45AE-8674-ADAE9C4B9520Q34502736-2BC0910E-7700-46C2-A17B-3F44ED6AAEE8Q34546916-BB201250-4B06-42CD-A159-7A6D2915B1E5Q34618893-F3698F77-5163-45E7-80C3-64C32D49DACCQ34718408-52682020-BB70-420B-ACF8-B68D74A80C83Q34778263-E98F4CE3-CC75-4702-8649-68D7A5DB6AE1Q35061235-AC0668B4-DBF3-44F3-A37E-D92C253A48B2Q35208854-A135BE2F-40FB-4FE9-B4B6-837CEAA34841Q35569293-DFE48F64-133F-4A14-97A9-DF69A0DCEE96Q35803289-05321C7F-7292-4503-B6EE-161AE3A4838AQ35860617-26D145EE-66BF-4FCD-A320-9B18A1C6F6B1Q36042053-533955CB-238F-4E38-8AA5-C331F71E49D0Q36076020-104EE9A2-5DAA-46F6-B6CC-8DB7250B05F1Q36130308-515738CB-77E1-480E-9F1E-FEDFB7F28FEFQ36266824-4C632F24-99C6-4714-A112-C28A2DC84BCDQ36412415-BFF5B561-39AD-41CC-B09C-EF9784253403Q36412566-1747F604-63F7-49FE-8EBA-6A3EECA46A70Q36422478-14518B97-6B3D-4616-9D4F-9B1B035B8EE8Q36436285-977C9387-12E7-4BEA-AF81-1BA30D331A21Q36436454-A8273329-B462-4B3D-9143-21540BDA3667Q36436497-78906D4F-EB27-41E3-A05B-01BAF0E33DA9Q36436542-031560D0-A1F5-4D19-B4CA-45CF054A9EACQ36436660-5E853828-68E6-43A6-84E8-E3843794E27BQ36444702-0BE0A357-34C3-4098-8CC5-B1B4AE261A2BQ36444788-A7D711AE-8798-4AB7-86D5-6F88245A323FQ36445212-5E10613D-5650-4E0A-B1EE-5C13C4BA69FA
P2860
The kinetic and physical basis of K(ATP) channel gating: toward a unified molecular understanding.
description
2000 nî lūn-bûn
@nan
2000 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2000 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2000年の論文
@ja
2000年論文
@yue
2000年論文
@zh-hant
2000年論文
@zh-hk
2000年論文
@zh-mo
2000年論文
@zh-tw
2000年论文
@wuu
name
The kinetic and physical basis of K
@nl
The kinetic and physical basis ...... ified molecular understanding.
@ast
The kinetic and physical basis ...... ified molecular understanding.
@en
type
label
The kinetic and physical basis of K
@nl
The kinetic and physical basis ...... ified molecular understanding.
@ast
The kinetic and physical basis ...... ified molecular understanding.
@en
prefLabel
The kinetic and physical basis of K
@nl
The kinetic and physical basis ...... ified molecular understanding.
@ast
The kinetic and physical basis ...... ified molecular understanding.
@en
P2093
P2860
P1433
P1476
The kinetic and physical basis ...... ified molecular understanding.
@en
P2093
C G Nichols
D Enkvetchakul
G Loussouarn
P2860
P304
P356
10.1016/S0006-3495(00)76779-8
P407
P577
2000-05-01T00:00:00Z