Interactions of a reversible ryanoid (21-amino-9alpha-hydroxy-ryanodine) with single sheep cardiac ryanodine receptor channels.
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The predicted TM10 transmembrane sequence of the cardiac Ca2+ release channel (ryanodine receptor) is crucial for channel activation and gatingLocalization of an NH(2)-terminal disease-causing mutation hot spot to the "clamp" region in the three-dimensional structure of the cardiac ryanodine receptor.Isoform-dependent formation of heteromeric Ca2+ release channels (ryanodine receptors).Block of the ryanodine receptor channel by neomycin is relieved at high holding potentialsRyanodine-induced structural alterations in the RyR channel suggested by neomycin block.Voltage-sensitive equilibrium between two states within a ryanoid-modified conductance state of the ryanodine receptor channelRyanodine receptor point mutant E4032A reveals an allosteric interaction with ryanodine.The contribution of hydrophobic residues in the pore-forming region of the ryanodine receptor channel to block by large tetraalkylammonium cations and Shaker B inactivation peptides.An anionic ryanoid, 10-O-succinoylryanodol, provides insights into the mechanisms governing the interaction of ryanoids and the subsequent altered function of ryanodine-receptor channelsThe interaction of a neutral ryanoid with the ryanodine receptor channel provides insights into the mechanisms by which ryanoid binding is modulated by voltage.Ryanoid modification of the cardiac muscle ryanodine receptor channel results in relocation of the tetraethylammonium binding site.Amitriptyline activates cardiac ryanodine channels and causes spontaneous sarcoplasmic reticulum calcium releaseUnambiguous observation of blocked states reveals altered, blocker-induced, cardiac ryanodine receptor gatingRole of the proposed pore-forming segment of the Ca2+ release channel (ryanodine receptor) in ryanodine interaction.Three-dimensional localization of divergent region 3 of the ryanodine receptor to the clamp-shaped structures adjacent to the FKBP binding sites.Ca2+-calmodulin increases RyR2 open probability yet reduces ryanoid association with RyR2.Ryanodine sensitizes the Ca(2+) release channel (ryanodine receptor) to Ca(2+) activation.Diketopyridylryanodine has three concentration-dependent effects on the cardiac calcium-release channel/ryanodine receptor.Calmodulin oxidation and methionine to glutamine substitutions reveal methionine residues critical for functional interaction with ryanodine receptor-1.Residue Gln4863 within a predicted transmembrane sequence of the Ca2+ release channel (ryanodine receptor) is critical for ryanodine interaction.
P2860
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P2860
Interactions of a reversible ryanoid (21-amino-9alpha-hydroxy-ryanodine) with single sheep cardiac ryanodine receptor channels.
description
1998 nî lūn-bûn
@nan
1998年の論文
@ja
1998年学术文章
@wuu
1998年学术文章
@zh-cn
1998年学术文章
@zh-hans
1998年学术文章
@zh-my
1998年学术文章
@zh-sg
1998年學術文章
@yue
1998年學術文章
@zh
1998年學術文章
@zh-hant
name
Interactions of a reversible r ...... c ryanodine receptor channels.
@ast
Interactions of a reversible r ...... c ryanodine receptor channels.
@en
type
label
Interactions of a reversible r ...... c ryanodine receptor channels.
@ast
Interactions of a reversible r ...... c ryanodine receptor channels.
@en
prefLabel
Interactions of a reversible r ...... c ryanodine receptor channels.
@ast
Interactions of a reversible r ...... c ryanodine receptor channels.
@en
P2093
P2860
P356
P1476
Interactions of a reversible r ...... c ryanodine receptor channels.
@en
P2093
P2860
P356
10.1085/JGP.112.1.55
P577
1998-07-01T00:00:00Z