Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins
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Specific neosaxitoxin interactions with the Na+ channel outer vestibule determined by mutant cycle analysis.Interactions of neosaxitoxin with the sodium channel of the frog skeletal muscle fiberUltra-slow inactivation in mu1 Na+ channels is produced by a structural rearrangement of the outer vestibuleFolding similarity of the outer pore region in prokaryotic and eukaryotic sodium channels revealed by docking of conotoxins GIIIA, PIIIA, and KIIIA in a NavAb-based model of Nav1.4.Electrophysiological effects of ryanodine derivatives on the sheep cardiac sarcoplasmic reticulum calcium-release channelThe saxitoxin/tetrodotoxin binding site on cloned rat brain IIa Na channels is in the transmembrane electric field.Differential effects of sulfhydryl reagents on saxitoxin and tetrodotoxin block of voltage-dependent Na channels.External cadmium and internal calcium block of single calcium channels in smooth muscle cells from rabbit mesenteric artery.Competitive binding interaction between Zn2+ and saxitoxin in cardiac Na+ channels. Evidence for a sulfhydryl group in the Zn2+/saxitoxin binding site.Differences in saxitoxin and tetrodotoxin binding revealed by mutagenesis of the Na+ channel outer vestibule.Saxitoxin blocks batrachotoxin-modified sodium channels in the node of Ranvier in a voltage-dependent manner.Open sodium channel properties of single canine cardiac Purkinje cells.Voltage-dependent activation in purified reconstituted sodium channels from rabbit T-tubular membranes.Discrimination of muscle and neuronal Na-channel subtypes by binding competition between [3H]saxitoxin and mu-conotoxins.Steric selectivity in Na channels arising from protein polarization and mobile side chains.An ion's view of the potassium channel. The structure of the permeation pathway as sensed by a variety of blocking ions.Single Na+ channels activated by veratridine and batrachotoxinBatrachotoxin-modified sodium channels in planar lipid bilayers. Characterization of saxitoxin- and tetrodotoxin-induced channel closures.Batrachotoxin-modified sodium channels from squid optic nerve in planar bilayers. Ion conduction and gating propertiesZn2(+)-induced subconductance events in cardiac Na+ channels prolonged by batrachotoxin. Current-voltage behavior and single-channel kinetics.On the interaction of bovine pancreatic trypsin inhibitor with maxi Ca(2+)-activated K+ channels. A model system for analysis of peptide-induced subconductance states.Ion permeation, divalent ion block, and chemical modification of single sodium channels. Description by single- and double-occupancy rate-theory models.An anionic ryanoid, 10-O-succinoylryanodol, provides insights into the mechanisms governing the interaction of ryanoids and the subsequent altered function of ryanodine-receptor channelsTrimethyloxonium modification of single batrachotoxin-activated sodium channels in planar bilayers. Changes in unit conductance and in block by saxitoxin and calciumInteractions of a reversible ryanoid (21-amino-9alpha-hydroxy-ryanodine) with single sheep cardiac ryanodine receptor channels.Trans-channel interactions in batrachotoxin-modified skeletal muscle sodium channels: voltage-dependent block by cytoplasmic amines, and the influence of mu-conotoxin GIIIA derivatives and permeant ionsSlow sodium conductances of dorsal root ganglion neurons: intraneuronal homogeneity and interneuronal heterogeneity.Functional reconstitution of the purified brain sodium channel in planar lipid bilayers.The tetrodotoxin binding site is within the outer vestibule of the sodium channel.Blocking mechanisms of batrachotoxin-activated Na channels in artificial bilayers.The sodium channel of excitable and non-excitable cells.Saxitoxin.Synthesis of saxitoxin derivatives bearing guanidine and urea groups at C13 and evaluation of their inhibitory activity on voltage-gated sodium channels.Profiles of permeation through Na-channels.Conotoxins as sensors of local pH and electrostatic potential in the outer vestibule of the sodium channel.Amine blockers of the cytoplasmic mouth of sodium channels: a small structural change can abolish voltage dependence.Subconductance block of single mechanosensitive ion channels in skeletal muscle fibers by aminoglycoside antibiotics.Synthesis of skeletal analogues of saxitoxin derivatives and evaluation of their inhibitory activity on sodium ion channels Na(V)1.4 and Na(V)1.5.On the mechanism by which saxitoxin binds to and blocks sodium channels.Functional reconstitution of purified sodium channels from brain in planar lipid bilayers.
P2860
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P2860
Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins
description
1984 nî lūn-bûn
@nan
1984年の論文
@ja
1984年学术文章
@wuu
1984年学术文章
@zh-cn
1984年学术文章
@zh-hans
1984年学术文章
@zh-my
1984年学术文章
@zh-sg
1984年學術文章
@yue
1984年學術文章
@zh
1984年學術文章
@zh-hant
name
Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins
@ast
Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins
@en
type
label
Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins
@ast
Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins
@en
prefLabel
Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins
@ast
Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins
@en
P2093
P2860
P356
P1476
Voltage-dependent blockade of muscle Na+ channels by guanidinium toxins
@en
P2093
E Moczydlowski
G S Strichartz
S S Garber
P2860
P304
P356
10.1085/JGP.84.5.687
P577
1984-11-01T00:00:00Z