DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses. - Wikidata - awgldk - TriplyDB

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.

http://www.wikidata.org/entity/Q36443943

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Parsing the players: 2-arachidonoylglycerol synthesis and degradation in the CNS Chemical probes of endocannabinoid metabolism AIG1 and ADTRP are atypical integral membrane hydrolases that degrade bioactive FAHFAs Database of Gene Co-Regulation (dGCR): A Web Tool for Analysing Patterns of Gene Co-regulation across Publicly Available Expression Data Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme Mapping the protein interaction landscape for fully functionalized small-molecule probes in human cells.ABHD6 blockade exerts antiepileptic activity in PTZ-induced seizures and in spontaneous seizures in R6/2 mice.A road map to evaluate the proteome-wide selectivity of covalent kinase inhibitors.Chemical approaches to therapeutically target the metabolism and signaling of the endocannabinoid 2-AG and eicosanoids Exploring metabolic pathways and regulation through functional chemoproteomic and metabolomic platforms Regulation of inflammation by cannabinoids, the endocannabinoids 2-arachidonoyl-glycerol and arachidonoyl-ethanolamide, and their metabolites.Acyl protein thioesterase inhibitors as probes of dynamic S-palmitoylation.Endocannabinoids and acute pain after total knee arthroplasty.Immunomodulatory lysophosphatidylserines are regulated by ABHD16A and ABHD12 interplay.Selective N-Hydroxyhydantoin Carbamate Inhibitors of Mammalian Serine Hydrolases Cannabinoid-induced chemotaxis in bovine corneal epithelial cells.Monoacylglycerol Lipase Regulates Fever Response Optimization of 1,2,5-thiadiazole carbamates as potent and selective ABHD6 inhibitors.Mapping proteome-wide interactions of reactive chemicals using chemoproteomic platforms.Myeloid-Specific Deletion of Diacylglycerol Lipase α Inhibits Atherogenesis in ApoE-Deficient Mice An in vivo multiplexed small-molecule screening platform.Comprehensive Analysis of Structure-Activity Relationships of α-Ketoheterocycles as sn-1-Diacylglycerol Lipase α Inhibitors Rapid and profound rewiring of brain lipid signaling networks by acute diacylglycerol lipase inhibition.A chemical proteomic atlas of brain serine hydrolases identifies cell type-specific pathways regulating neuroinflammation.Selective inhibitors and tailored activity probes for lipoprotein-associated phospholipase A(2)Diacylglycerol lipase disinhibits VTA dopamine neurons during chronic nicotine exposure.Diacylglycerol lipase β inhibition reverses nociceptive behaviour in mouse models of inflammatory and neuropathic pain.Modulating the endocannabinoid system in human health and disease--successes and failures Diacylglycerol lipaseα (DAGLα) and DAGLβ cooperatively regulate the production of 2-arachidonoyl glycerol in autaptic hippocampal neurons.Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition.Serine hydrolase inhibitors block necrotic cell death by preventing calcium overload of the mitochondria and permeability transition pore formation.Development and optimization of piperidyl-1,2,3-triazole ureas as selective chemical probes of endocannabinoid biosynthesis.Discovery and optimization of piperidyl-1,2,3-triazole ureas as potent, selective, and in vivo-active inhibitors of α/β-hydrolase domain containing 6 (ABHD6)Analysis of ECs and related compounds in plasma: artifactual isomerization and ex vivo enzymatic generation of 2-MGs.Determining target engagement in living systems Chemical modulation of glycerolipid signaling and metabolic pathways.Endocannabinoids and neuropathic pain: focus on neuron-glia and endocannabinoid-neurotrophin interactions.The Endogenous Cannabinoid System: A Budding Source of Targets for Treating Inflammatory and Neuropathic Pain.An Introduction to the Endogenous Cannabinoid System.Oxyradical Stress, Endocannabinoids, and Atherosclerosis.

P2860

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P2860

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.

http://www.wikidata.org/entity/Q36443943

description

2012 nî lūn-bûn

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2012年の論文

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年学术文章

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2012年學術文章

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2012年學術文章

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2012年學術文章

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name

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.

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DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.

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type

label

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.

@ast

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.

@en

prefLabel

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.

@ast

DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.

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Nature Chemical Biology

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DAGLβ inhibition perturbs a lipid network involved in macrophage inflammatory responses.

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P2093

Alexander Adibekian

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Holly Pugh

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Katsunori Tsuboi

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Kim Masuda

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P2860

Cloning of the first sn1-DAG lipases points to the spatial and temporal regulation of endocannabinoid signaling in the brain

Brain monoglyceride lipase participating in endocannabinoid inactivation

Selective blockade of 2-arachidonoylglycerol hydrolysis produces cannabinoid behavioral effects

The serine hydrolase ABHD6 controls the accumulation and efficacy of 2-AG at cannabinoid receptors

A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol

Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling

Endocannabinoid oxygenation by cyclooxygenases, lipoxygenases, and cytochromes P450: cross-talk between the eicosanoid and endocannabinoid signaling pathways

Discovery and Characterization of a Highly Selective FAAH Inhibitor that Reduces Inflammatory Pain

2-Arachidonoylglycerol: a possible endogenous cannabinoid receptor ligand in brain

Identification of an endogenous 2-monoglyceride, present in canine gut, that binds to cannabinoid receptors

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999-1007

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10.1038/NCHEMBIO.1105

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12

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8

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Benjamin Cravatt III

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2012-10-28T00:00:00Z

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232720426

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23103940

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Diacylglycerol lipase, beta

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3513945

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