Allosteric regulation of BK channel gating by Ca(2+) and Mg(2+) through a nonselective, low affinity divalent cation site
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Activation and inhibition of TMEM16A calcium-activated chloride channelsDistinct gating mechanisms revealed by the structures of a multi-ligand gated K(+) channelMammalian MagT1 and TUSC3 are required for cellular magnesium uptake and vertebrate embryonic developmentStructure of the gating ring from the human large-conductance Ca(2+)-gated K(+) channelGating mechanism of BK (Slo1) channels: so near, yet so farInactivation of BK channels by the NH2 terminus of the beta2 auxiliary subunit: an essential role of a terminal peptide segment of three hydrophobic residuesRegulation of bestrophin Cl channels by calcium: role of the C terminusThe RCK2 domain of the human BKCa channel is a calcium sensorBeta1 subunits facilitate gating of BK channels by acting through the Ca2+, but not the Mg2+, activating mechanismsSlo3 K+ channels: voltage and pH dependence of macroscopic currentsBK channels: multiple sensors, one activation gateCrystal Structure of a Ba2+-Bound Gating Ring Reveals Elementary Steps in RCK Domain ActivationStimulatory action of internal protons on Slo1 BK channelsExtracellular chloride regulation of Kv2.1, contributor to the major outward Kv current in mammalian outer hair cells.Generation of functional fluorescent BK channels by random insertion of GFP variantsGlycine311, a determinant of paxilline block in BK channels: a novel bend in the BK S6 helix.Cysteine residue 911 in C-terminal tail of human BK(Ca)α channel subunit is crucial for its activation by carbon monoxide.Structural determinants of phosphatidylinositol 4,5-bisphosphate (PIP2) regulation of BK channel activity through the RCK1 Ca2+ coordination site.Stepwise contribution of each subunit to the cooperative activation of BK channels by Ca2+.Redox-sensitive extracellular gates formed by auxiliary beta subunits of calcium-activated potassium channels.Inhibition of large-conductance Ca2+-activated K+ channels by nanomolar concentrations of Ag+.Paxilline inhibits BK channels by an almost exclusively closed-channel block mechanism.Molecular architecture and divalent cation activation of TvoK, a prokaryotic potassium channelSetting the stage for molecular dissection of the regulatory components of BK channels.Single-channel kinetics of BK (Slo1) channels.Tuning magnesium sensitivity of BK channels by mutations.Metal-driven operation of the human large-conductance voltage- and Ca2+-dependent potassium channel (BK) gating ring apparatus.Cadmium-cysteine coordination in the BK inner pore region and its structural and functional implicationsMg(2+) binding to open and closed states can activate BK channels provided that the voltage sensors are elevatedParticipation of the S4 voltage sensor in the Mg2+-dependent activation of large conductance (BK) K+ channels.The BKCa channel's Ca2+-binding sites, multiple sites, multiple ionsBarium ions selectively activate BK channels via the Ca2+-bowl siteMg2+ mediates interaction between the voltage sensor and cytosolic domain to activate BK channelsEffects of multiple metal binding sites on calcium and magnesium-dependent activation of BK channelsMechanism of beta4 subunit modulation of BK channels.Intra- and intersubunit cooperativity in activation of BK channels by Ca2+Modulation of the conductance-voltage relationship of the BK Ca channel by mutations at the putative flexible interface between two RCK domains.Mg2+ enhances voltage sensor/gate coupling in BK channels.Cysteine modification alters voltage- and Ca(2+)-dependent gating of large conductance (BK) potassium channels.Differential effects of beta 1 and beta 2 subunits on BK channel activity.
P2860
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P2860
Allosteric regulation of BK channel gating by Ca(2+) and Mg(2+) through a nonselective, low affinity divalent cation site
description
2001 nî lūn-bûn
@nan
2001年の論文
@ja
2001年学术文章
@wuu
2001年学术文章
@zh-cn
2001年学术文章
@zh-hans
2001年学术文章
@zh-my
2001年学术文章
@zh-sg
2001年學術文章
@yue
2001年學術文章
@zh
2001年學術文章
@zh-hant
name
Allosteric regulation of BK ch ...... affinity divalent cation site
@ast
Allosteric regulation of BK ch ...... affinity divalent cation site
@en
type
label
Allosteric regulation of BK ch ...... affinity divalent cation site
@ast
Allosteric regulation of BK ch ...... affinity divalent cation site
@en
prefLabel
Allosteric regulation of BK ch ...... affinity divalent cation site
@ast
Allosteric regulation of BK ch ...... affinity divalent cation site
@en
P2860
P356
P1476
Allosteric regulation of BK ch ...... affinity divalent cation site
@en
P2093
P2860
P304
P356
10.1085/JGP.118.5.607
P577
2001-11-01T00:00:00Z