Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis. - Wikidata - awgldk - TriplyDB

Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis.

Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis.

http://www.wikidata.org/entity/Q36446197

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The protein kinase IKKepsilon regulates energy balance in obese mice Herbal medicines for the treatment of nonalcoholic steatohepatitis: current scenario and future prospects Simple sugar intake and hepatocellular carcinoma: epidemiological and mechanistic insight Genetically modified mouse models for the study of nonalcoholic fatty liver disease Myeloid cell-restricted insulin receptor deficiency protects against obesity-induced inflammation and systemic insulin resistance Implication of inflammatory signaling pathways in obesity-induced insulin resistance Impaired de novo choline synthesis explains why phosphatidylethanolamine N-methyltransferase-deficient mice are protected from diet-induced obesity Dietary and genetic obesity promote liver inflammation and tumorigenesis by enhancing IL-6 and TNF expression Mechanisms for insulin resistance: common threads and missing links Macrophage function in obesity-induced inflammation and insulin resistance.Genome-wide mRNA expression analysis of hepatic adaptation to high-fat diets reveals switch from an inflammatory to steatotic transcriptional program.Local non-esterified fatty acids correlate with inflammation in atheroma plaques of patients with type 2 diabetes.TAK1-mediated autophagy and fatty acid oxidation prevent hepatosteatosis and tumorigenesis Cell penetrating peptide inhibitors of nuclear factor-kappa B.An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice Alteration of JNK-1 signaling in skeletal muscle fails to affect glucose homeostasis and obesity-associated insulin resistance in mice The metabolically benign and malignant fatty liver.Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals NF-κB in the liver--linking injury, fibrosis and hepatocellular carcinoma.Cancer microenvironment and cancer vaccine.Correlation between blood activin levels and clinical parameters of type 2 diabetes.Prohibitin-induced, obesity-associated insulin resistance and accompanying low-grade inflammation causes NASH and HCC Rutaecarpine ameliorates hyperlipidemia and hyperglycemia in fat-fed, streptozotocin-treated rats via regulating the IRS-1/PI3K/Akt and AMPK/ACC2 signaling pathways Murine Models of Nonalcoholic Fatty Liver Disease and Steatohepatitis.Obesity, cancer, and acetyl-CoA metabolism.PPARs Mediate Lipid Signaling in Inflammation and Cancer.Trans-10, cis-12-conjugated linoleic acid alters hepatic gene expression in a polygenic obese line of mice displaying hepatic lipidosis.The Role of NF-kappaB in PPARalpha-Mediated Hepatocarcinogenesis.Inactivation of NF-kappaB p50 leads to insulin sensitization in liver through post-translational inhibition of p70S6K Diet-induced obesity increases NF-kappaB signaling in reporter mice.Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1.Obesity, inflammation, and liver cancer.MyD88 signaling in the CNS is required for development of fatty acid-induced leptin resistance and diet-induced obesity.Small-molecule inhibitors of PKR improve glucose homeostasis in obese diabetic mice.The Role of Immunogenicity in Cardiovascular Disease.Role of nuclear factor kappaB in liver health and disease.NF-κB, inflammation, and metabolic disease.Dissociating fatty liver and diabetes Glucagon-like peptide-1 inhibits adipose tissue macrophage infiltration and inflammation in an obese mouse model of diabetes.TNF-dependent signaling pathways in liver cancer: promising targets for therapeutic strategies?.

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Hepatic NF-kappa B essential modulator deficiency prevents obesity-induced insulin resistance but synergizes with high-fat feeding in tumorigenesis.

http://www.wikidata.org/entity/Q36446197

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2008年学术文章

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2008年学术文章

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2008年学术文章

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2008年學術文章

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2008年學術文章

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2008年學術文章

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Hepatic NF-kappa B essential m ...... -fat feeding in tumorigenesis.

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Hepatic NF-kappa B essential m ...... -fat feeding in tumorigenesis.

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Hepatic NF-kappa B essential m ...... -fat feeding in tumorigenesis.

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Proceedings of the National Academy of Sciences of the United States of America

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Hepatic NF-kappa B essential m ...... -fat feeding in tumorigenesis.

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F Thomas Wunderlich

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Julia Baumgartl

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Marc Schmidt-Supprian

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Peter Schirmacher

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Stephan Singer

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Tom Luedde

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P2860

Chronic inflammation in fat plays a crucial role in the development of obesity-related insulin resistance

Adipose expression of tumor necrosis factor-alpha: direct role in obesity-linked insulin resistance

Reversal of obesity- and diet-induced insulin resistance with salicylates or targeted disruption of Ikkbeta

Fatty acids and retinoids control lipid metabolism through activation of peroxisome proliferator-activated receptor-retinoid X receptor heterodimers

Sterol regulatory element-binding protein-1 as a key transcription factor for nutritional induction of lipogenic enzyme genes

Increased adipose tissue expression of tumor necrosis factor-alpha in human obesity and insulin resistance

IKK-beta links inflammation to obesity-induced insulin resistance

NF-kappaB functions as a tumour promoter in inflammation-associated cancer

Local and systemic insulin resistance resulting from hepatic activation of IKK-beta and NF-kappaB

IRS-1-mediated inhibition of insulin receptor tyrosine kinase activity in TNF-alpha- and obesity-induced insulin resistance

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10.1073/PNAS.0707849104

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105

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Manolis Pasparakis

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Jens C Brüning

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2008-01-23T00:00:00Z

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5635990

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18216263

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