Ligand directed signaling differences between rodent and human κ-opioid receptors.

Ligand directed signaling differences between rodent and human κ-opioid receptors.

Item
http://www.wikidata.org/entity/Q36451846
The G protein-biased κ-opioid receptor agonist RB-64 is analgesic with a unique spectrum of activities in vivoMolecular determinants of the human α2C-adrenergic receptor temperature-sensitive intracellular trafficSelective κ receptor partial agonist HS666 produces potent antinociception without inducing aversion after i.c.v. administration in mice.The kappa opioid receptor: from addiction to depression, and back.Intrinsic relative activities of κ opioid agonists in activating Gα proteins and internalizing receptor: Differences between human and mouse receptors.Functional selectivity of kappa opioid receptor agonists in peripheral sensory neurons.Development of κ opioid receptor antagonists.The G-protein biased partial κ opioid receptor agonist 6'-GNTI blocks hippocampal paroxysmal discharges without inducing aversion.JNK3 enzyme binding to arrestin-3 differentially affects the recruitment of upstream mitogen-activated protein (MAP) kinase kinasesHuman native kappa opioid receptor functions not predicted by recombinant receptors: Implications for drug designTargeting individual GPCRs with redesigned nonvisual arrestins.Nalfurafine is a G-protein biased agonist having significantly greater bias at the human than rodent form of the kappa opioid receptor.
P2860

Ligand directed signaling differences between rodent and human κ-opioid receptors.

Item
http://www.wikidata.org/entity/Q36451846
description
2012 nî lūn-bûn
@nan
2012年の論文
@ja
2012年学术文章
@wuu
2012年学术文章
@zh-cn
2012年学术文章
@zh-hans
2012年学术文章
@zh-my
2012年学术文章
@zh-sg
2012年學術文章
@yue
2012年學術文章
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2012年學術文章
@zh-hant
name
Ligand directed signaling differences between rodent and human κ-opioid receptors.
@ast
Ligand directed signaling differences between rodent and human κ-opioid receptors.
@en
type
label
Ligand directed signaling differences between rodent and human κ-opioid receptors.
@ast
Ligand directed signaling differences between rodent and human κ-opioid receptors.
@en
prefLabel
Ligand directed signaling differences between rodent and human κ-opioid receptors.
@ast
Ligand directed signaling differences between rodent and human κ-opioid receptors.
@en
P1433
P1476
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932
P356
P1433
P1476
Ligand directed signaling differences between rodent and human κ-opioid receptors.
@en
P2093
P2860
P304
P31
P356
P407
P433
P478
P50
P577
P698
P921
P932